MicroRNA-135b promotes proliferation, invasion and migration of osteosarcoma cells by degrading myocardin

International Journal of Oncology

Volumn 45, Issue 5, 2014, Pages 2024-2032

  Xu, Wei Guo ^a   Shang, Ying Lie ^b,c   Cong, Xian Rui ^a   Bian, Xia ^d   Yuan, Zhen ^c  

^a Shanxian County Dongda Hospital   (China)

^b 2nd People's Hospital of Dongying   (China)

^c SHANDONG UNIVERSITY   (China)

^d DONGYING PEOPLE S HOSPITAL   (China)

Author keywords

MiR 135b; Myocardin; Osteosarcoma

Indexed keywords

MICRORNA; MICRORNA 135B; MYOCARDIN; UNCLASSIFIED DRUG; MIRN135 MICRORNA, HUMAN; NUCLEAR PROTEIN; TRANSACTIVATOR PROTEIN;

3' UNTRANSLATED REGION; ARTICLE; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; GENE OVEREXPRESSION; GENE SILENCING; GENE TARGETING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; OSTEOSARCOMA CELL; PROTEIN DEGRADATION; ANTAGONISTS AND INHIBITORS; BONE TUMOR; CELL MOTION; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; OSTEOSARCOMA; PATHOLOGY; TUMOR CELL LINE; TUMOR INVASION;

BONE NEOPLASMS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICRORNAS; NEOPLASM INVASIVENESS; NUCLEAR PROTEINS; OSTEOSARCOMA; PROTEOLYSIS; TRANS-ACTIVATORS;

EID: 84907224723     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2014.2641     Document Type: Article

References (27)

1. Bielack SS, Marina N, Ferrari S, Helman LJ, Smeland S, Whelan JS, et al: Osteosarcoma: The same old drugs or more? J Clin Oncol 26: 3102-3103, 2008.
2. Chou AJ, Geller DS and Gorlick R: Therapy for osteosarcoma: Where do we go from here? Paediatr Drugs 10: 315-327, 2008.
3. O'Day K and Gorlick R: Novel therapeutic agents for osteosarcoma. Expert Rev Anticancer Ther 9: 511-523, 2009.
4. Wang D, Chang PS, Wang Z, Sutherland L, Richardson JA, et al: Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor. Cell 105: 851-862, 2001.
5. Yoshida T, Sinha S, Dandré F, Wamhoff BR, Hoofnagle MH, et al: Myocardin is a key regulator of CArG-dependent transcription of multiple smooth muscle marker genes. Circ Res 92: 856-864, 2003.
6. Shore P and Sharrocks AD: The MADS-box family of transcription factors. Eur J Biochem 229: 1-13, 1995.
7. Pipes GC, Creemers EE and Olson EN: The myocardin family of transcriptional coactivators: Versatile regulators of cell growth, migration, and myogenesis. Genes Dev 20: 1545-1556, 2006.
8. Lulla RR, Costa FF, Bischof JM, Chou PM, de F Bonaldo M, Vanin EF and Soares MB: Identification of Differentially expressed microRNAs in osteosarcoma. Sarcoma 2011: 732690, 2011.
9. Jones KB, Salah Z, Del Mare S, Galasso M, Gaudio E, Nuovo GJ, Lovat F, LeBlanc K, Palatini J, Randall RL, Volinia S, Stein GS, Croce CM, Lian JB and Aqeilan RI: MiRNA signatures associate with pathogenesis and progression of osteosarcoma. Cancer Res 72: 1865-1877, 2012.
10. Zhang H, Cai X, Wang Y, Tang H, Tong D and Ji F: MicroRNA-143, down-regulated in osteosarcoma, promotes apoptosis and suppresses tumorigenicity by targeting Bcl-2. Oncol Rep 24: 1363-1369, 2010.
11. Duan Z, Choy E, Harmon D, Liu X, Susa M, Mankin H and Hornicek F: MicroRNA-199a-3p is downregulated in human osteosarcoma and regulates cell proliferation and migration. Mol Cancer Ther 10: 1337-1345, 2011.
12. Osaki M, Takeshita F, Sugimoto Y, Kosaka N, Yamamoto Y, Yoshioka Y, Kobayashi E, Yamada T, Kawai A, Inoue T, Ito H, Oshimura M and Ochiya T: MicroRNA-143 regulates human osteosarcoma metastasis by regulating matrix metalloprotease-13 expression. Mol Ther 19: 1123-1130, 2011.
13. Ziyan W, Shuhua Y, Xiufang W and Xiaoyun L: MicroRNA-21 is involved in osteosarcoma cell invasion and migration. Med Oncol 28: 1469-1474, 2011.
14. Arigoni M, Barutello G, Riccardo F, Ercole E, Cantarella D, Orso F, Conti L, Lanzardo S, Taverna D, Merighi I, Calogero RA, Cavallo F and Quaglino E: MiR-135b coordinates progression of ErbB2-driven mammary carcinomas through suppression of MID1 and MTCH2. Am J Pathol 182: 2058-2070, 2013.
15. Lin CW, Chang YL, Chang YC, Lin JC, Chen CC, Pan SH, Wu CT, Chen HY, Yang SC, Hong TM and Yang PC: MicroRNA-135b promotes lung cancer metastasis by regulating multiple targets in the Hippo pathway and LZTS1. Nat Commun 4: 1877, 2013.
16. Zhang L, Sun ZJ, Bian Y and Kulkarni AB: MicroRNA-135b acts as a tumor promoter by targeting the hypoxia-inducible factor pathway in genetically defined mouse model of head and neck squamous cell carcinoma. Cancer Lett 331: 230-238, 2013.
17. Matsuyama H, Suzuki HI, Nishimori H, Noguchi M, Yao T, Komatsu N, Mano H, Sugimoto K and Miyazono K: MiR-135b mediates NPM-ALK-driven oncogenicity and renders IL-17-producing immunophenotype to anaplastic large cell lymphoma. Blood 118: 6881-6892, 2011.
18. Khatri R and Subramanian S: MicroRNA-135b and its circuitry networks as potential therapeutic targets in colon cancer. Front Oncol 3: 268, 2013.
19. Holycross BJ, Blank RS, Thompson MM, Peach MJ and Owens GK: Platelet-derived growth factor-BB-induced suppression of smooth muscle cell differentiation. Circ Res 71: 1525-1532, 1992.
20. Luo XG, Zou JN, Wang SZ, Zhang TC and Xi T: Novobiocin decreases SMYD3 expression and inhibits the migration of MDA-MB-231 human breast cancer cells. IUBMB Life 62: 194-199, 2010.
21. Liao XH, Wang N, Liu QX, Qin T, Cao B, et al: Myocardin-related transcription factor-A induces cardiomyocyte hypertrophy. IUBMB Life 63: 54-61, 2011.
22. Frasor J, Danes JM, Komm B, Chang KC, Lyttle CR and Katzenellenbogen BS: Profiling of estrogen up-and downregulated gene expression in human breast cancer cells: Insights into gene networks and pathways underlying estrogenic control of proliferation and cell phenotype. Endocrinology 144: 4562-4574, 2003.
23. Yu J, Ryan DG, Getsios S, Oliveira-Fernandes M, Fatima A and Lavker RM: MicroRNA-184 antagonizes microRNA-205 to maintain SHIP2 levels in epithelia. Proc Natl Acad Sci USA 105: 19300-19305, 2008.
24. Lu J, Getz G, Miska EA, Alvarez-Saavedra E, Lamb J, Peck D, Sweet-Cordero A, Ebert BL, Mak RH, Ferrando AA, Downing JR, Jacks T, Horvitz HR and Golub TR: MicroRNA expression profiles classify human cancers. Nature 435: 834-838, 2005.
25. Bandres E, Cubedo E, Agirre X, Malumbres R, Zarate R, Ramirez N, et al: Identification by real-time PCR of 13 mature microRNAs differentially expressed in colorectal cancer and non-tumoral tissues. Mol Cancer 5: 29, 2006.
26. Lowery AJ, Miller N, Devaney A, Mcneill RE, Davoren PA, Lemetre C, et al: MicroRNA signatures predict oestrogen receptor, progesterone receptor and HER2/neu receptor status in breast cancer. Breast Cancer Res 11: R27, 2009.
27. Tong AW, Fulgham P, Jay C, Chen P, Khalil I, Liu S, et al: MicroRNA profile analysis of human prostate cancers. Cancer Gene Ther 16: 206-216, 2013.