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Volumn 49, Issue 8, 2014, Pages 752-762

Apremilast

Author keywords

[No Author keywords available]

Indexed keywords

APREMILAST; CARBAMAZEPINE; METHOTREXATE; PHENOBARBITAL; PHENYTOIN; PLACEBO; RIFAMPICIN;

EID: 84907204178     PISSN: 00185787     EISSN: 19451253     Source Type: Journal    
DOI: 10.1310/hpj4908-752     Document Type: Review
Times cited : (14)

References (25)
  • 1
    • 84907215410 scopus 로고    scopus 로고
    • (apremilast) [prescribing information]. Summit, NJ: Celgene Corporation; March
    • Otezla (apremilast) [prescribing information]. Summit, NJ: Celgene Corporation; March 2014.
    • (2014) Otezla
  • 2
    • 84881475901 scopus 로고    scopus 로고
    • Effi cacy and safety of apremilast, an oral phosphodiesterase 4 inhibitor, in ankylosing spondylitis
    • Pathan E, Abraham S, Van Rossen E, et al. Effi cacy and safety of apremilast, an oral phosphodiesterase 4 inhibitor, in ankylosing spondylitis. Ann Rheum Dis. 2013;72(9):1475-1480.
    • (2013) Ann Rheum Dis. , vol.72 , Issue.9 , pp. 1475-1480
    • Pathan, E.1    Abraham, S.2    Van Rossen, E.3
  • 3
    • 84865373941 scopus 로고    scopus 로고
    • Effi cacy of apremilast in the treatment of moderate to severe psoriasis: A randomized controlled trial
    • Papp K, Cather JC, Rosoph L, et al. Effi cacy of apremilast in the treatment of moderate to severe psoriasis: A randomized controlled trial. Lancet. 2012;380(9843):738-746.
    • (2012) Lancet. , vol.380 , Issue.9843 , pp. 738-746
    • Papp, K.1    Cather, J.C.2    Rosoph, L.3
  • 4
    • 84874110064 scopus 로고    scopus 로고
    • Effi cacy and safety of apremilast in subjects with moderate to severe plaque psoriasis: Results from a phase II, multicenter, randomized, double-blind, placebo-controlled, parallel-group, dose-comparison study
    • Papp KA, Kaufmann R, Thaçi D, Hu C, Sutherland D, Rohane P. Effi cacy and safety of apremilast in subjects with moderate to severe plaque psoriasis: Results from a phase II, multicenter, randomized, double-blind, placebo-controlled, parallel-group, dose-comparison study. J Eur Acad Dermatol Venereol. 2013;27(3):e376-e383.
    • (2013) J Eur Acad Dermatol Venereol. , vol.27 , Issue.3 , pp. e376-e383
    • Papp, K.A.1    Kaufmann, R.2    Thaçi, D.3    Hu, C.4    Sutherland, D.5    Rohane, P.6
  • 5
    • 84860175869 scopus 로고    scopus 로고
    • Apremilast mechanism of action and application to psoriasis and psoriatic arthritis
    • Schafer P. Apremilast mechanism of action and application to psoriasis and psoriatic arthritis. Biochem Pharmacol. 2012;83(12):1583-1590.
    • (2012) Biochem Pharmacol. , vol.83 , Issue.12 , pp. 1583-1590
    • Schafer, P.1
  • 6
    • 77249116286 scopus 로고    scopus 로고
    • Apremilast, a cAMP phosphodiesterase-4 inhibitor, demonstrates antiinfl ammatory activity in vitro and in a model of psoriasis
    • Schafer PH, Parton A, Gandhi AK, et al. Apremilast, a cAMP phosphodiesterase-4 inhibitor, demonstrates antiinfl ammatory activity in vitro and in a model of psoriasis. Br J Pharmacol. 2010;159(4):842-855.
    • (2010) Br J Pharmacol. , vol.159 , Issue.4 , pp. 842-855
    • Schafer, P.H.1    Parton, A.2    Gandhi, A.K.3
  • 7
    • 44349161096 scopus 로고    scopus 로고
    • An open-label, single-arm pilot study in patients with severe plaque-type psoriasis treated with an oral anti-infl ammatory agent, apremilast
    • Gottlieb AB, Strober B, Krueger JG, et al. An open-label, single-arm pilot study in patients with severe plaque-type psoriasis treated with an oral anti-infl ammatory agent, apremilast. Curr Med Res Opin. 2008;24(5):1529-1538.
    • (2008) Curr Med Res Opin. , vol.24 , Issue.5 , pp. 1529-1538
    • Gottlieb, A.B.1    Strober, B.2    Krueger, J.G.3
  • 8
    • 84869014252 scopus 로고    scopus 로고
    • Oral apremilast in the treatment of active psoriatic arthritis: Results of a multicenter, randomized, double-blind, placebo-controlled study
    • Schett G, Wollenhaupt J, Papp K, et al. Oral apremilast in the treatment of active psoriatic arthritis: Results of a multicenter, randomized, double-blind, placebo-controlled study. Arthritis Rheum. 2012;64(10):3156-3167.
    • (2012) Arthritis Rheum. , vol.64 , Issue.10 , pp. 3156-3167
    • Schett, G.1    Wollenhaupt, J.2    Papp, K.3
  • 9
    • 80655145912 scopus 로고    scopus 로고
    • Disposition, metabolism and mass balance of [(14)C]apremilast following oral administration
    • Hoffmann M, Kumar G, Schafer P, et al. Disposition, metabolism and mass balance of [(14)C]apremilast following oral administration. Xenobiotica. 2011;41(12):1063-1075
    • (2011) Xenobiotica. , vol.41 , Issue.12 , pp. 1063-1075
    • Hoffmann, M.1    Kumar, G.2    Schafer, P.3
  • 10
    • 84858636270 scopus 로고    scopus 로고
    • A phase 2, open-label, investigator-initiated study to evaluate the safety and effi cacy of apremilast in subjects with recalcitrant allergic contact or atopic dermatitis
    • Volf EM, Au SC, Dumont N, Scheinman P, Gottlieb AB. A phase 2, open-label, investigator-initiated study to evaluate the safety and effi cacy of apremilast in subjects with recalcitrant allergic contact or atopic dermatitis. J Drugs Dermatol. 2012;11(3):341-346.
    • (2012) J Drugs Dermatol. , vol.11 , Issue.3 , pp. 341-346
    • Volf, E.M.1    Au, S.C.2    Dumont, N.3    Scheinman, P.4    Gottlieb, A.B.5
  • 11
    • 78649804751 scopus 로고    scopus 로고
    • Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis
    • McCann FE, Palfreeman AC, Andrews M, et al. Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis. Arthritis Res Ther. 2010;12(3):R107.
    • (2010) Arthritis Res Ther. , vol.12 , Issue.3 , pp. R107
    • McCann, F.E.1    Palfreeman, A.C.2    Andrews, M.3
  • 12
    • 84901818469 scopus 로고    scopus 로고
    • Safety/tolerability and pharmacokinetics of multiple oral doses of apremilast in healthy male subjects [abstract]
    • Wu A, Rohane P, Ng J, et al. Safety/tolerability and pharmacokinetics of multiple oral doses of apremilast in healthy male subjects [abstract]. Clin Pharmacol Ther. 2012;91:S26.
    • (2012) Clin Pharmacol Ther. , vol.91 , pp. S26
    • Wu, A.1    Rohane, P.2    Ng, J.3
  • 13
    • 79958800583 scopus 로고    scopus 로고
    • Guidelines of care for the management of psoriasis and psoriatic arthritis: Section 6. Guidelines of care for the treatment of psoriasis and psoriatic arthritis: Case-based presentations and evidencebased conclusions
    • Menter A, Korman NJ, Elmets CA, et al. Guidelines of care for the management of psoriasis and psoriatic arthritis: Section 6. Guidelines of care for the treatment of psoriasis and psoriatic arthritis: Case-based presentations and evidencebased conclusions. J Am Acad Dermatol. 2011;65(1):137-174.
    • (2011) J Am Acad Dermatol. , vol.65 , Issue.1 , pp. 137-174
    • Menter, A.1    Korman, N.J.2    Elmets, C.A.3
  • 14
    • 84901855662 scopus 로고    scopus 로고
    • Apremilast, an oral phosphodiesterase 4 inhibitor, in patients with moderate to severe psoriasis: 16-week results of a phase III, randomized, controlled trial (ESTEEM 1) [abstract]
    • Reich K, Papp K, Leonardi C, et al. Apremilast, an oral phosphodiesterase 4 inhibitor, in patients with moderate to severe psoriasis: 16-week results of a phase III, randomized, controlled trial (ESTEEM 1) [abstract]. J Eur Acad Dermatol. 2013;27(Suppl 4):22.
    • (2013) J Eur Acad Dermatol. , vol.27 , pp. 22
    • Reich, K.1    Papp, K.2    Leonardi, C.3
  • 16
    • 84896105372 scopus 로고    scopus 로고
    • Apremilast, an oral phosphodiesterase 4 inhibitor, is associated with long-term (52-week) improvement in physical function in patients with psoriatic arthritis: Results from three phase 3, randomized, controlled trials [abstract]
    • Schett G, Mease PJ, Gladman DD, et al. Apremilast, an oral phosphodiesterase 4 inhibitor, is associated with long-term (52-week) improvement in physical function in patients with psoriatic arthritis: Results from three phase 3, randomized, controlled trials [abstract]. Arthritis Rheum. 2013;65(10):S143.
    • (2013) Arthritis Rheum. , vol.65 , Issue.10 , pp. S143
    • Schett, G.1    Mease, P.J.2    Gladman, D.D.3
  • 17
    • 84898900966 scopus 로고    scopus 로고
    • Apremilast, an oral phosphodiesterase 4 inhibitor, is associated with longterm (52-week) improvement in tender and swollen joint counts in patients with psoriatic arthritis: Results from three phase 3, randomized, controlled trials [abstract]
    • Cutolo M, Mease PJ, Gladman DD, et al. Apremilast, an oral phosphodiesterase 4 inhibitor, is associated with longterm (52-week) improvement in tender and swollen joint counts in patients with psoriatic arthritis: Results from three phase 3, randomized, controlled trials [abstract]. Arthritis Rheum. 2013;65(10):S135.
    • (2013) Arthritis Rheum. , vol.65 , Issue.10 , pp. S135
    • Cutolo, M.1    Mease, P.J.2    Gladman, D.D.3
  • 18
    • 84899868819 scopus 로고    scopus 로고
    • Longterm (52-week) results of a phase 3, randomized, controlled trial of apremilast, an oral phosphodiesterase 4 inhibitor, in patients with psoriatic arthritis (PALACE 2) [abstract]
    • Cutolo M, Myerson GE, Fleischmann RM, et al. Longterm (52-week) results of a phase 3, randomized, controlled trial of apremilast, an oral phosphodiesterase 4 inhibitor, in patients with psoriatic arthritis (PALACE 2) [abstract]. Arthritis Rheum. 2013;65(10):S346-S347.
    • (2013) Arthritis Rheum. , vol.65 , Issue.10 , pp. S346-S347
    • Cutolo, M.1    Myerson, G.E.2    Fleischmann, R.M.3
  • 19
    • 84901841741 scopus 로고    scopus 로고
    • Long-term safety and tolerability of apremilast, an oral phosphodiesterase 4 inhibitor, in patients with psoriatic arthritis: Pooled safety analysis of three phase 3, randomized, controlled trials [abstract]
    • Mease PJ, Kavanaugh A, Galdman DD, et al. Long-term safety and tolerability of apremilast, an oral phosphodiesterase 4 inhibitor, in patients with psoriatic arthritis: Pooled safety analysis of three phase 3, randomized, controlled trials [abstract]. Arthritis Rheum. 2013;65(10):S131.
    • (2013) Arthritis Rheum. , vol.65 , Issue.10 , pp. S131
    • Mease, P.J.1    Kavanaugh, A.2    Galdman, D.D.3
  • 20
    • 84901824985 scopus 로고    scopus 로고
    • Laboratory abnormalities in patients with psoriatic arthritis receiving apremilast, an oral phosphodiesterase 4 inhibitor: Pooled safety analysis of three phase 3, randomized, controlled trials [abstract]
    • Mease PJ, Kavanaugh A, Adebajo AO, et al. Laboratory abnormalities in patients with psoriatic arthritis receiving apremilast, an oral phosphodiesterase 4 inhibitor: Pooled safety analysis of three phase 3, randomized, controlled trials [abstract]. Arthritis Rheum. 2013;65(10):S151.
    • (2013) Arthritis Rheum. , vol.65 , Issue.10 , pp. S151
    • Mease, P.J.1    Kavanaugh, A.2    Adebajo, A.O.3
  • 21
    • 84901833481 scopus 로고    scopus 로고
    • Long-term (52 week) results of a phase 3 randomized, controlled trial of apremilast, an oral phosphodiesterase 4 inhibitor, in patients with psoriatic arthritis and current skin involvement (PALACE 3) [abstract]
    • Edwards CJ, Blanco FJ, Crowley J, et al. Long-term (52 week) results of a phase 3 randomized, controlled trial of apremilast, an oral phosphodiesterase 4 inhibitor, in patients with psoriatic arthritis and current skin involvement (PALACE 3) [abstract]. Arthritis Rheum. 2013;65(10):S132.
    • (2013) Arthritis Rheum. , vol.65 , Issue.10 , pp. S132
    • Edwards, C.J.1    Blanco, F.J.2    Crowley, J.3
  • 22
    • 84899981396 scopus 로고    scopus 로고
    • Treatment of psoriatic arthritis in a phase 3 randomised, placebocontrolled trial with apremilast, an oral phosphodiesterase 4 inhibitor
    • Kavanaugh A, Mease PJ, Gomez-Reino JJ, et al. Treatment of psoriatic arthritis in a phase 3 randomised, placebocontrolled trial with apremilast, an oral phosphodiesterase 4 inhibitor. Ann Rheum Dis. 2014;73(6):1020-1026.
    • (2014) Ann Rheum Dis. , vol.73 , Issue.6 , pp. 1020-1026
    • Kavanaugh, A.1    Mease, P.J.2    Gomez-Reino, J.J.3
  • 23
    • 84907210582 scopus 로고    scopus 로고
    • Apremilast, an oral phosphodiesterase 4 inhibitor, in patients with psoriatic arthritis: Results of a phase 3, randomized, controlled trial (PALACE 1) [abstract]
    • Adebajo AO, Kavanaugh A, Mease PJ, et al. Apremilast, an oral phosphodiesterase 4 inhibitor, in patients with psoriatic arthritis: Results of a phase 3, randomized, controlled trial (PALACE 1) [abstract]. J Eur Acad Dermatol Vernereol. 2013;27(suppl 4):53-54.
    • (2013) J Eur Acad Dermatol Vernereol. , vol.27 , pp. 53-54
    • Adebajo, A.O.1    Kavanaugh, A.2    Mease, P.J.3
  • 24
    • 84901851651 scopus 로고    scopus 로고
    • Apremilast in the treatment of DMARD-naive psoriatic arthritis patients: Results of a phase 3 randomized, controlled trial (PALACE 4) [abstract]
    • Wells AF, Edwards CJ, Adebajo AO, et al. Apremilast in the treatment of DMARD-naive psoriatic arthritis patients: Results of a phase 3 randomized, controlled trial (PALACE 4) [abstract]. Arthritis Rheum. 2013;65(12):3320-3321.
    • (2013) Arthritis Rheum. , vol.65 , Issue.12 , pp. 3320-3321
    • Wells, A.F.1    Edwards, C.J.2    Adebajo, A.O.3
  • 25
    • 84907189377 scopus 로고    scopus 로고
    • US Food and Drug Administration Web site Published March 21, 2014. Accessed March 31, 2014
    • Parks MH. NDA approval letter: Otezla (apremilast NDA 205437). US Food and Drug Administration Web site. http://www.accessdata.fda.gov/drugsatfda-docs/appletter/2014/20 5437Orig1s000ltr.pdf. Published March 21, 2014. Accessed March 31, 2014.
    • NDA Approval Letter: Otezla (Apremilast NDA 205437)
    • Parks, M.H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.