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Volumn 32, Issue 27, 2014, Pages 2932-2934

PIK3CA activating mutations: A discordant role in early versus advanced hormone-dependent estrogen receptor-positive breast cancer?

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE 3 KINASE CATALYTIC SUBUNIT ALPHA; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; PIK3CA PROTEIN, HUMAN; PROTEIN KINASE B; TUMOR MARKER;

EID: 84907199373     PISSN: 0732183X     EISSN: 15277755     Source Type: Journal    
DOI: 10.1200/JCO.2014.55.9591     Document Type: Editorial
Times cited : (30)

References (27)
  • 1
    • 67749122122 scopus 로고    scopus 로고
    • Targeting PI3K signalling in cancer: Opportunities, challenges and limitations
    • Engelman JA: Targeting PI3K signalling in cancer: Opportunities, challenges and limitations. Nat Rev Cancer 9: 550-562, 2009
    • (2009) Nat Rev Cancer , vol.9 , pp. 550-562
    • Engelman, J.A.1
  • 2
    • 84877028141 scopus 로고    scopus 로고
    • Comprehensive molecular portraits of human breast tumours
    • Cancer Genome Atlas Network: Comprehensive molecular portraits of human breast tumours. Nature 490: 61-70, 2012
    • (2012) Nature , vol.490 , pp. 61-70
  • 3
    • 20444374445 scopus 로고    scopus 로고
    • Mutant PIK3CA promotes cell growth and invasion of human cancer cells
    • Samuels Y, Diaz LA Jr, Schmidt-Kittler O, et al: Mutant PIK3CA promotes cell growth and invasion of human cancer cells. Cancer Cell 7: 561-573, 2005
    • (2005) Cancer Cell , vol.7 , pp. 561-573
    • Samuels, Y.1    Diaz, L.A.2    Schmidt-Kittler, O.3
  • 4
    • 28244479028 scopus 로고    scopus 로고
    • Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells
    • Isakoff SJ, Engelman JA, Irie HY, et al: Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells. Cancer Res 65: 10992-11000, 2005
    • (2005) Cancer Res , vol.65 , pp. 10992-11000
    • Isakoff, S.J.1    Engelman, J.A.2    Irie, H.Y.3
  • 5
    • 56449111358 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/phosphatidylinositol 3-kinase inhibitor NVP-BEZ235
    • Eichhorn PJ, Gili M, Scaltriti M, et al: Phosphatidylinositol 3-kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/phosphatidylinositol 3-kinase inhibitor NVP-BEZ235. Cancer Res 68: 9221-9230, 2008
    • (2008) Cancer Res , vol.68 , pp. 9221-9230
    • Eichhorn, P.J.1    Gili, M.2    Scaltriti, M.3
  • 6
    • 77956913409 scopus 로고    scopus 로고
    • H1047R phosphatidylinositol 3-kinase mutant enhances HER2-mediated transformation by heregulin production and activation of HER3
    • Chakrabarty A, Rexer BN, Wang SE, et al: H1047R phosphatidylinositol 3-kinase mutant enhances HER2-mediated transformation by heregulin production and activation of HER3. Oncogene 29: 5193-5203, 2010
    • (2010) Oncogene , vol.29 , pp. 5193-5203
    • Chakrabarty, A.1    Rexer, B.N.2    Wang, S.E.3
  • 7
    • 34250749822 scopus 로고    scopus 로고
    • PIK3CA mutations and PTEN loss correlate with similar prognostic factors and are not mutually exclusive in breast cancer
    • Pérez-Tenorio G, Alkhori L, Olsson B, et al: PIK3CA mutations and PTEN loss correlate with similar prognostic factors and are not mutually exclusive in breast cancer. Clin Cancer Res 13: 3577-3584, 2007
    • (2007) Clin Cancer Res , vol.13 , pp. 3577-3584
    • Pérez-Tenorio, G.1    Alkhori, L.2    Olsson, B.3
  • 8
    • 51049118140 scopus 로고    scopus 로고
    • An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer
    • Stemke-Hale K, Gonzalez-Angulo AM, Lluch A, et al: An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer. Cancer Res 68: 6084-6091, 2008
    • (2008) Cancer Res , vol.68 , pp. 6084-6091
    • Stemke-Hale, K.1    Gonzalez-Angulo, A.M.2    Lluch, A.3
  • 9
    • 77953422867 scopus 로고    scopus 로고
    • PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptor-positive breast cancer
    • Loi S, Haibe-Kains B, Majjaj S, et al: PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptor-positive breast cancer. Proc Natl Acad Sci USA 107: 10208-10213, 2010
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 10208-10213
    • Loi, S.1    Haibe-Kains, B.2    Majjaj, S.3
  • 10
    • 74849112055 scopus 로고    scopus 로고
    • Phosphatidyl-inositol-3-kinase alpha catalytic subunit mutation and response to neoadjuvant endocrine therapy for estrogen receptor positive breast cancer
    • Ellis MJ, Lin L, Crowder R, et al: Phosphatidyl-inositol-3-kinase alpha catalytic subunit mutation and response to neoadjuvant endocrine therapy for estrogen receptor positive breast cancer. Breast Cancer Res Treat 119: 379-390, 2010
    • (2010) Breast Cancer Res Treat , vol.119 , pp. 379-390
    • Ellis, M.J.1    Lin, L.2    Crowder, R.3
  • 11
    • 77954974573 scopus 로고    scopus 로고
    • Hyperactivation of phosphatidylinositol-3 kinase promotes escape from hormone dependence in estrogen receptor-positive human breast cancer
    • Miller TW, Hennessy BT, González-Angulo AM, et al: Hyperactivation of phosphatidylinositol-3 kinase promotes escape from hormone dependence in estrogen receptor-positive human breast cancer. J Clin Invest 120: 2406-2413, 2010
    • (2010) J Clin Invest , vol.120 , pp. 2406-2413
    • Miller, T.W.1    Hennessy, B.T.2    González-Angulo, A.M.3
  • 12
    • 84907208070 scopus 로고    scopus 로고
    • Mutational analysis of PI3K/AKT signaling pathway in tamoxifen exemestane adjuvant multinational pathology study
    • Sabine VS, Crozier C, Brookes CL, et al: Mutational analysis of PI3K/AKT signaling pathway in tamoxifen exemestane adjuvant multinational pathology study. J Clin Oncol 32: 2951-2958, 2014
    • (2014) J Clin Oncol , vol.32 , pp. 2951-2958
    • Sabine, V.S.1    Crozier, C.2    Brookes, C.L.3
  • 13
    • 78751647876 scopus 로고    scopus 로고
    • Adjuvant tamoxifen and exemestane in early breast cancer (TEAM): A randomised phase 3 trial
    • van de Velde CJ, Rea D, Seynaeve C, et al: Adjuvant tamoxifen and exemestane in early breast cancer (TEAM): A randomised phase 3 trial. Lancet 377: 321-331, 2011
    • (2011) Lancet , vol.377 , pp. 321-331
    • Van De-Velde, C.J.1    Rea, D.2    Seynaeve, C.3
  • 14
    • 69349105634 scopus 로고    scopus 로고
    • PIK3CA mutation associates with improved outcome in breast cancer
    • Kalinsky K, Jacks LM, Heguy A, et al: PIK3CA mutation associates with improved outcome in breast cancer. Clin Cancer Res 15: 5049-5059, 2009
    • (2009) Clin Cancer Res , vol.15 , pp. 5049-5059
    • Kalinsky, K.1    Jacks, L.M.2    Heguy, A.3
  • 15
    • 84864558874 scopus 로고    scopus 로고
    • Randomized phase II trial of everolimus in combination with tamoxifen in patients with hormone receptorpositive, human epidermal growth factor receptor 2-negative metastatic breast cancer with prior exposure to aromatase inhibitors: A GINECO study
    • Bachelot T, Bourgier C, Cropet C, et al: Randomized phase II trial of everolimus in combination with tamoxifen in patients with hormone receptorpositive, human epidermal growth factor receptor 2-negative metastatic breast cancer with prior exposure to aromatase inhibitors: A GINECO study. J Clin Oncol 30: 2718-2724, 2012
    • (2012) J Clin Oncol , vol.30 , pp. 2718-2724
    • Bachelot, T.1    Bourgier, C.2    Cropet, C.3
  • 16
    • 84863078767 scopus 로고    scopus 로고
    • Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer
    • Baselga J, Campone M, Piccart M, et al: Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer. N Engl J Med 366: 520-529, 2012
    • (2012) N Engl J Med , vol.366 , pp. 520-529
    • Baselga, J.1    Campone, M.2    Piccart, M.3
  • 17
    • 84885435345 scopus 로고    scopus 로고
    • Correlation of molecular alterations with efficacy of everolimus in hormone receptor-positive (HR+), HER2-negative advanced breast cancer: Results from BOLERO-2
    • (abstr LBA509)
    • Hortobagyi GN, Piccart-Gebhart MJ, Rugo HS, et al: Correlation of molecular alterations with efficacy of everolimus in hormone receptor-positive (HR+), HER2-negative advanced breast cancer: Results from BOLERO-2. J Clin Oncol 31: 9s, 2013 (suppl; abstr LBA509)
    • (2013) J Clin Oncol , vol.31 , pp. 9s
    • Hortobagyi, G.N.1    Piccart-Gebhart, M.J.2    Rugo, H.S.3
  • 18
    • 65949110376 scopus 로고    scopus 로고
    • PIK3CA and PIK3CB inhibition produce synthetic lethality when combined with estrogen deprivation in estrogen receptor-positive breast cancer
    • Crowder RJ, Phommaly C, Tao Y, et al: PIK3CA and PIK3CB inhibition produce synthetic lethality when combined with estrogen deprivation in estrogen receptor-positive breast cancer. Cancer Res 69: 3955-3962, 2009
    • (2009) Cancer Res , vol.69 , pp. 3955-3962
    • Crowder, R.J.1    Phommaly, C.2    Tao, Y.3
  • 19
    • 84880015651 scopus 로고    scopus 로고
    • Autocrine IGF-I/insulin receptor axis compensates for inhibition of AKT in ER-positive breast cancer cells with resistance to estrogen deprivation
    • Fox EM, Kuba MG, Miller TW, et al: Autocrine IGF-I/insulin receptor axis compensates for inhibition of AKT in ER-positive breast cancer cells with resistance to estrogen deprivation. Breast Cancer Res 15: R55, 2013
    • (2013) Breast Cancer Res , vol.15 , pp. R55
    • Fox, E.M.1    Kuba, M.G.2    Miller, T.W.3
  • 20
    • 84904724740 scopus 로고    scopus 로고
    • Stand up to cancer phase Ib study of pan-phosphoinositide-3-kinase inhibitor buparlisib with letrozole in estrogen receptor-positive/human epidermal growth factor receptor 2-negative metastatic breast cancer
    • Mayer IA, Abramson VG, Isakoff SJ, et al: Stand up to cancer phase Ib study of pan-phosphoinositide-3-kinase inhibitor buparlisib with letrozole in estrogen receptor-positive/human epidermal growth factor receptor 2-negative metastatic breast cancer. J Clin Oncol 32: 1202-1209, 2014
    • (2014) J Clin Oncol , vol.32 , pp. 1202-1209
    • Mayer, I.A.1    Abramson, V.G.2    Isakoff, S.J.3
  • 21
    • 79951834210 scopus 로고    scopus 로고
    • PIK3CA mutations may be discordant between primary and corresponding metastatic disease in breast cancer
    • Dupont Jensen J, Laenkholm AV, Knoop A, et al: PIK3CA mutations may be discordant between primary and corresponding metastatic disease in breast cancer. Clin Cancer Res 17: 667-677, 2011
    • (2011) Clin Cancer Res , vol.17 , pp. 667-677
    • Dupont Jensen, J.1    Laenkholm, A.V.2    Knoop, A.3
  • 22
    • 79958728268 scopus 로고    scopus 로고
    • PI3K pathway mutations and PTEN levels in primary and metastatic breast cancer
    • Gonzalez-Angulo AM, Ferrer-Lozano J, Stemke-Hale K, et al: PI3K pathway mutations and PTEN levels in primary and metastatic breast cancer. Mol Cancer Ther 10: 1093-1101, 2011
    • (2011) Mol Cancer Ther , vol.10 , pp. 1093-1101
    • Gonzalez-Angulo, A.M.1    Ferrer-Lozano, J.2    Stemke-Hale, K.3
  • 23
    • 84907188334 scopus 로고    scopus 로고
    • Autocrine IGF-I/insulin receptor axis compensates for inhibition of AKT in ER-positive breast cancer cells with resistance to estrogen deprivation
    • (abstr CT-01)
    • Juric D, Rodon J, Gonzalez-Angulo AM, et al: Autocrine IGF-I/insulin receptor axis compensates for inhibition of AKT in ER-positive breast cancer cells with resistance to estrogen deprivation. Cancer Res 72, 2012 (suppl 1; abstr CT-01)
    • (2012) Cancer Res , vol.72
    • Juric, D.1    Rodon, J.2    Gonzalez-Angulo, A.M.3
  • 24
    • 24944497744 scopus 로고    scopus 로고
    • Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib
    • Eberhard DA, Johnson BE, Amler LC, et al: Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib. J Clin Oncol 23: 5900-5909, 2005
    • (2005) J Clin Oncol , vol.23 , pp. 5900-5909
    • Eberhard, D.A.1    Johnson, B.E.2    Amler, L.C.3
  • 25
    • 69949162760 scopus 로고    scopus 로고
    • Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
    • Mok TS, Wu YL, Thongprasert S, et al: Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med 361: 947-957, 2009
    • (2009) N Engl J Med , vol.361 , pp. 947-957
    • Mok, T.S.1    Wu, Y.L.2    Thongprasert, S.3
  • 26
    • 75249087060 scopus 로고    scopus 로고
    • Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): An open label, randomised phase 3 trial
    • Mitsudomi T, Morita S, Yatabe Y, et al: Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): An open label, randomised phase 3 trial. Lancet Oncol 11: 121-128, 2010
    • (2010) Lancet Oncol , vol.11 , pp. 121-128
    • Mitsudomi, T.1    Morita, S.2    Yatabe, Y.3
  • 27
    • 77953930730 scopus 로고    scopus 로고
    • Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR
    • Maemondo M, Inoue A, Kobayashi K, et al: Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. N Engl J Med 362: 2380-2388, 2010
    • (2010) N Engl J Med , vol.362 , pp. 2380-2388
    • Maemondo, M.1    Inoue, A.2    Kobayashi, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.