Discovery of (E)-5-(benzylideneamino)-1H-benzo[d]imidazol-2(3H)-one derivatives as inhibitors for PTK6

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 19, 2014, Pages 4659-4663

  Shim, Hyun Jae ^a   Yang, Hye Ran ^b   Kim, Han Ie ^a,d   Kang, Shin Ae ^a   No, Kyoung Tai ^a,c   Jung, Young Hoon ^b   Lee, Seung Taek ^a  

^a Yonsei University   (South Korea)

^b Sungkyunkwan University   (South Korea)

^c Bioinformatics and Molecular Design Research Center (BMDRC)   (South Korea)

^d Shingyeong University   (South Korea)

Author keywords

Catalytic activity; Inhibitor; PTK6; Structure activity relationship

Indexed keywords

5 (BENZYLIDENEAMINO) 1H BENZO[D]IMIDAZOL 2 (3H)ONE DERIVATIVE; GENISTEIN; PROTEIN TYROSINE KINASE 6 INHIBITOR; PROTEIN TYROSINE KINASE INHIBITOR; TYRPHOSTIN; UNCLASSIFIED DRUG; 5-((2,3-DIBROMO-5-ETHOXY-6-HYDROXYBENZYLIDENE)AMINO)-1H-BENZO(D)IMIDAZOL-2(3H)-ONE; 5-((2,3-DIBROMO-6-HYDROXY-5-METHOXYBENZYLIDENE)AMINO)-1H-BENZO(D)IMIDAZOL-2(3H)-ONE; BENZIMIDAZOLE DERIVATIVE; PROTEIN KINASE INHIBITOR; PROTEIN TYROSINE KINASE; PTK6 PROTEIN, HUMAN; SCHIFF BASE; TUMOR PROTEIN;

ARTICLE; CATALYSIS; CELL LEVEL; CONTROLLED STUDY; CYTOTOXICITY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME SUBSTRATE; FIBROBLAST; HEK293 CELL LINE; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; MTT ASSAY; PREPUCE; PROTEIN PHOSPHORYLATION; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; CYTOLOGY; DOSE RESPONSE; DRUG DEVELOPMENT; DRUG EFFECTS; MALE; METABOLISM; SYNTHESIS;

BENZIMIDAZOLES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; FIBROBLASTS; FORESKIN; HEK293 CELLS; HUMANS; MALE; MOLECULAR STRUCTURE; NEOPLASM PROTEINS; PROTEIN KINASE INHIBITORS; PROTEIN-TYROSINE KINASES; SCHIFF BASES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84907198606     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.08.036     Document Type: Article

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