메뉴 건너뛰기




Volumn 7, Issue , 2014, Pages 1593-1599

Arsenic trioxide-based therapy in relapsed/refractory multiple myeloma patients: A meta-analysis and systematic review

Author keywords

Arsenic trioxide; Clinical trial; Meta analysis; Multiple myeloma; Therapy

Indexed keywords

ARSENIC TRIOXIDE; ASCORBIC ACID; BORTEZOMIB; DEXAMETHASONE; MELPHALAN; THALIDOMIDE;

EID: 84907194011     PISSN: None     EISSN: 11786930     Source Type: Journal    
DOI: 10.2147/OTT.S67165     Document Type: Article
Times cited : (15)

References (49)
  • 1
    • 67849084851 scopus 로고    scopus 로고
    • The efficacy of arsenic trioxide for the treatment of relapsed and refractory multiple myeloma: A systematic review
    • Rollig C, Illmer T. The efficacy of arsenic trioxide for the treatment of relapsed and refractory multiple myeloma: a systematic review. Cancer Treat Rev. 2009;35:425–430.
    • (2009) Cancer Treat Rev. , vol.35 , pp. 425-430
    • Rollig, C.1    Illmer, T.2
  • 4
    • 85061220270 scopus 로고    scopus 로고
    • Targeting the mitochondria: An exciting new approach to myeloma therapy. Commentary re: Bahlis NJ, et al. Feasibility and correlates of arsenic trioxide combined with ascorbic acid-mediated depletion of intracellular glutathione for the treatment of relapsed/ refractory multiple myeloma
    • Dalton WS. Targeting the mitochondria: an exciting new approach to myeloma therapy. Commentary re: Bahlis NJ, et al. Feasibility and correlates of arsenic trioxide combined with ascorbic acid-mediated depletion of intracellular glutathione for the treatment of relapsed/ refractory multiple myeloma. Clin Cancer Res. 2002;8:3658–3668.
    • (2002) Clin Cancer Res. , vol.8 , pp. 3658-3668
    • Dalton, W.S.1
  • 5
    • 0031657760 scopus 로고    scopus 로고
    • Involvement of reactive oxygen species and caspase 3 activation in arsenite-induced apoptosis
    • Chen YC, Lin-Shiau SY, Lin JK. Involvement of reactive oxygen species and caspase 3 activation in arsenite-induced apoptosis. J Cell Physiol. 1998;177:324–333.
    • (1998) J Cell Physiol , vol.177 , pp. 324-333
    • Chen, Y.C.1    Lin-Shiau, S.Y.2    Lin, J.K.3
  • 6
    • 0033974883 scopus 로고    scopus 로고
    • Arsenic trioxide-induced apoptosis and differentiation are associated respectively with mitochondrial transmembrane potential collapse and retinoic acid signaling pathways in acute promyelocytic leukemia
    • Cai X, Shen YL, Zhu Q, et al. Arsenic trioxide-induced apoptosis and differentiation are associated respectively with mitochondrial transmembrane potential collapse and retinoic acid signaling pathways in acute promyelocytic leukemia. Leukemia. 2000;14:262–270.
    • (2000) Leukemia , vol.14 , pp. 262-270
    • Cai, X.1    Shen, Y.L.2    Zhu, Q.3
  • 7
    • 0035240425 scopus 로고    scopus 로고
    • Arsenic trioxide induces multiple myeloma cell apoptosis via disruption of mitochondrial transmembrane potentials and activation of caspase-3
    • Jia P, Chen G, Huang X, et al. Arsenic trioxide induces multiple myeloma cell apoptosis via disruption of mitochondrial transmembrane potentials and activation of caspase-3. Chin Med J (Engl). 2001; 114:19–24.
    • (2001) Chin Med J (Engl) , vol.114 , pp. 19-24
    • Jia, P.1    Chen, G.2    Huang, X.3
  • 8
    • 0030610686 scopus 로고    scopus 로고
    • Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): I. As2O3 exerts dose-dependent dual effects on APL cells
    • Chen GQ, Shi XG, Tang W, et al. Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): I. As2O3 exerts dose-dependent dual effects on APL cells. Blood. 1997;89:3345–3353.
    • (1997) Blood , vol.89 , pp. 3345-3353
    • Chen, G.Q.1    Shi, X.G.2    Tang, W.3
  • 9
    • 0030610687 scopus 로고    scopus 로고
    • Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients
    • Shen ZX, Chen GQ, Ni JH, et al. Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients. Blood. 1997;89:3354–3360.
    • (1997) Blood , vol.89 , pp. 3354-3360
    • Shen, Z.X.1    Chen, G.Q.2    Ni, J.H.3
  • 10
    • 0034212785 scopus 로고    scopus 로고
    • Arsenic trioxide-mediated growth inhibition in MC/CAR myeloma cells via cell cycle arrest in association with induction of cyclin-dependent kinase inhibitor, p21, and apoptosis
    • Park WH, Seol JG, Kim ES, et al. Arsenic trioxide-mediated growth inhibition in MC/CAR myeloma cells via cell cycle arrest in association with induction of cyclin-dependent kinase inhibitor, p21, and apoptosis. Cancer Res. 2000;60:3065–3071.
    • (2000) Cancer Res. , vol.60 , pp. 3065-3071
    • Park, W.H.1    Seol, J.G.2    Kim, E.S.3
  • 11
    • 18544367201 scopus 로고    scopus 로고
    • NF-kappa B as a therapeutic target in multiple myeloma
    • Hideshima T, Chauhan D, Richardson P, et al. NF-kappa B as a therapeutic target in multiple myeloma. J Biol Chem. 2002;277:16639–16647.
    • (2002) J Biol Chem , vol.277 , pp. 16639-16647
    • Hideshima, T.1    Chauhan, D.2    Richardson, P.3
  • 12
    • 84871376638 scopus 로고    scopus 로고
    • Alterations in glutathione levels and apoptotic regulators are associated with acquisition of arsenic trioxide resistance in multiple myeloma
    • Matulis SM, Morales AA, Yehiayan L, Lee K P, Cai Y, Boise LH. Alterations in glutathione levels and apoptotic regulators are associated with acquisition of arsenic trioxide resistance in multiple myeloma. PLoS One. 2012;7:e52662.
    • (2012) PLoS One , vol.7
    • Matulis, S.M.1    Morales, A.A.2    Yehiayan, L.3    Lee, K.P.4    Cai, Y.5    Boise, L.H.6
  • 13
    • 18244428600 scopus 로고    scopus 로고
    • Criteria for evaluating disease response and progression in patients with multiple myeloma treated by high-dose therapy and haemopoietic stem cell transplantation. Myeloma Subcommittee of the EBMT. European Group for Blood and Marrow Transplant
    • Blade J, Samson D, Reece D, et al. Criteria for evaluating disease response and progression in patients with multiple myeloma treated by high-dose therapy and haemopoietic stem cell transplantation. Myeloma Subcommittee of the EBMT. European Group for Blood and Marrow Transplant. Br J Haematol. 1998;102:1115–1123.
    • (1998) Br J Haematol , vol.102 , pp. 1115-1123
    • Blade, J.1    Samson, D.2    Reece, D.3
  • 14
    • 43049117226 scopus 로고    scopus 로고
    • Phase II clinical trial of arsenic trioxide with liposomal doxo-rubicin, vincristine, and dexamethasone in newly diagnosed multiple myeloma
    • Hofmeister CC, Jansak B, Denlinger N, Kraut EH, Benson DM, Farag SS. Phase II clinical trial of arsenic trioxide with liposomal doxo-rubicin, vincristine, and dexamethasone in newly diagnosed multiple myeloma. Leuk Res. 2008;32:1295–1298.
    • (2008) Leuk Res , vol.32 , pp. 1295-1298
    • Hofmeister, C.C.1    Jansak, B.2    Denlinger, N.3    Kraut, E.H.4    Benson, D.M.5    Farag, S.S.6
  • 15
    • 0036896388 scopus 로고    scopus 로고
    • Feasibility and correlates of arsenic trioxide combined with ascorbic acid-mediated depletion of intracellular glutathione for the treatment of relapsed/ refractory multiple myeloma
    • Bahlis NJ, McCafferty-Grad J, Jordan-McMurry I, et al. Feasibility and correlates of arsenic trioxide combined with ascorbic acid-mediated depletion of intracellular glutathione for the treatment of relapsed/ refractory multiple myeloma. Clin Cancer Res. 2002;8:3658–3668.
    • (2002) Clin Cancer Res , vol.8 , pp. 3658-3668
    • Bahlis, N.J.1    McCafferty-Grad, J.2    Jordan-McMurry, I.3
  • 16
    • 5744232817 scopus 로고    scopus 로고
    • A prospective, open-label safety and efficacy study of combination treatment with melphalan, arsenic trioxide, and ascorbic acid in patients with relapsed or refractory multiple myeloma
    • Berenson JR, Swift RA, Ferretti D, Purner MB. A prospective, open-label safety and efficacy study of combination treatment with melphalan, arsenic trioxide, and ascorbic acid in patients with relapsed or refractory multiple myeloma. Clin Lymphoma. 2004;5:130–134.
    • (2004) Clin Lymphoma , vol.5 , pp. 130-134
    • Berenson, J.R.1    Swift, R.A.2    Ferretti, D.3    Purner, M.B.4
  • 17
    • 11844266523 scopus 로고    scopus 로고
    • Efficacy of melphalan, arsenic trioxide, and ascorbic acid combination therapy (MAC) in relapsed and refractory multiple myeloma
    • Borad MJ, Swift R, Berenson JR. Efficacy of melphalan, arsenic trioxide, and ascorbic acid combination therapy (MAC) in relapsed and refractory multiple myeloma. Leukemia. 2005;19:154–156.
    • (2005) Leukemia , vol.19 , pp. 154-156
    • Borad, M.J.1    Swift, R.2    Berenson, J.R.3
  • 18
    • 67849134083 scopus 로고    scopus 로고
    • Trisenox (arsenic trioxide) in the treatment for multiple myeloma after bone marrow transplantation
    • Gesundheit B, Shapira MY, Resnick I, et al. Trisenox (arsenic trioxide) in the treatment for multiple myeloma after bone marrow transplantation. Blood. 2005;106:365B.
    • (2005) Blood , vol.106 , pp. 365B
    • Gesundheit, B.1    Shapira, M.Y.2    Resnick, I.3
  • 19
    • 0036739745 scopus 로고    scopus 로고
    • Clinical activity of arsenic trioxide for the treatment of multiple myeloma
    • Munshi NC, Tricot G, Desikan R, et al. Clinical activity of arsenic trioxide for the treatment of multiple myeloma. Leukemia. 2002;16:1835–1837.
    • (2002) Leukemia , vol.16 , pp. 1835-1837
    • Munshi, N.C.1    Tricot, G.2    Desikan, R.3
  • 20
    • 4444275232 scopus 로고    scopus 로고
    • A clinical and pharmacological study of arsenic trioxide in advanced multiple myeloma patients
    • Rousselot P, Larghero J, Arnulf B, et al. A clinical and pharmacological study of arsenic trioxide in advanced multiple myeloma patients. Leukemia. 2004;18:1518–1521.
    • (2004) Leukemia , vol.18 , pp. 1518-1521
    • Rousselot, P.1    Larghero, J.2    Arnulf, B.3
  • 21
    • 84875033710 scopus 로고    scopus 로고
    • A Phase I study of arsenic trioxide (Trisenox), ascorbic acid, and bortezomib (Velcade) combination therapy in patients with relapsed/refractory multiple myeloma
    • Held LA, Rizzieri D, Long GD, et al. A Phase I study of arsenic trioxide (Trisenox), ascorbic acid, and bortezomib (Velcade) combination therapy in patients with relapsed/refractory multiple myeloma. Cancer Invest. 2013;31:172–176.
    • (2013) Cancer Invest , vol.31 , pp. 172-176
    • Held, L.A.1    Rizzieri, D.2    Long, G.D.3
  • 22
    • 80054770297 scopus 로고    scopus 로고
    • Arsenic trioxide in patients with refractory multiple myeloma: A prospective, phase II, single-arm study
    • Sanaat Z, Rezazadeh M, Gharamaleki J V, Ziae JE, Esfahani A. Arsenic trioxide in patients with refractory multiple myeloma: a prospective, phase II, single-arm study. Acta Med Iran. 2011;49:504–508.
    • (2011) Acta Med Iran , vol.49 , pp. 504-508
    • Sanaat, Z.1    Rezazadeh, M.2    Gharamaleki, J.V.3    Ziae, J.E.4    Esfahani, A.5
  • 23
    • 67849083834 scopus 로고    scopus 로고
    • Arsenic trioxide for treatment of multiple myeloma
    • Dey S, Gupta P, Chitalkar PG, Mukhopadhyay A. Arsenic trioxide for treatment of multiple myeloma. Ann Oncol. 2007;18:9178–9182.
    • (2007) Ann Oncol , vol.18 , pp. 9178-9182
    • Dey, S.1    Gupta, P.2    Chitalkar, P.G.3    Mukhopadhyay, A.4
  • 24
    • 56549083786 scopus 로고    scopus 로고
    • Arsenic trioxide with ascorbic acid and high-dose melphalan: Results of a phase II randomized trial
    • Qazilbash MH, Saliba RM, Nieto Y, et al. Arsenic trioxide with ascorbic acid and high-dose melphalan: results of a phase II randomized trial. Biol Blood Marrow Transplant. 2008;14:1401–1407.
    • (2008) Biol Blood Marrow Transplant , vol.14 , pp. 1401-1407
    • Qazilbash, M.H.1    Saliba, R.M.2    Nieto, Y.3
  • 25
    • 34250194653 scopus 로고    scopus 로고
    • A phase I/II study of arsenic trioxide/bortezomib/ascorbic acid combination therapy for the treatment of relapsed or refractory multiple myeloma
    • Berenson JR, Matous J, Swift RA, Mapes R, Morrison B, Ye h HS. A phase I/II study of arsenic trioxide/bortezomib/ascorbic acid combination therapy for the treatment of relapsed or refractory multiple myeloma. Clin Cancer Res. 2007;13:1762–1768.
    • (2007) Clin Cancer Res , vol.13 , pp. 1762-1768
    • Berenson, J.R.1    Matous, J.2    Swift, R.A.3    Mapes, R.4    Morrison, B.5    Ye H, H.S.6
  • 26
    • 33748755948 scopus 로고    scopus 로고
    • Efficacy and safety of melphalan, arsenic trioxide and ascorbic acid combination therapy in patients with relapsed or refractory multiple myeloma: A prospective, multicentre, phase II, single-arm study
    • Berenson JR, Boccia R, Siegel D, et al. Efficacy and safety of melphalan, arsenic trioxide and ascorbic acid combination therapy in patients with relapsed or refractory multiple myeloma: a prospective, multicentre, phase II, single-arm study. Br J Haematol. 2006;135:174–183.
    • (2006) Br J Haematol , vol.135 , pp. 174-183
    • Berenson, J.R.1    Boccia, R.2    Siegel, D.3
  • 27
    • 33646884415 scopus 로고    scopus 로고
    • Efficacy and safety results with the combination therapy of arsenic trioxide, dexamethasone, and ascorbic acid in multiple myeloma patients: A phase 2 trial
    • Abou-Jawde RM, Reed J, Kelly M, et al. Efficacy and safety results with the combination therapy of arsenic trioxide, dexamethasone, and ascorbic acid in multiple myeloma patients: a phase 2 trial. Med Oncol. 2006;23:263–272.
    • (2006) Med Oncol , vol.23 , pp. 263-272
    • Abou-Jawde, R.M.1    Reed, J.2    Kelly, M.3
  • 28
    • 33845952602 scopus 로고    scopus 로고
    • Phase II multicenter study of arsenic trioxide, ascorbic acid and dexamethasone in patients with relapsed or refractory multiple myeloma
    • Wu KL, Beksac M, van Droogenbroeck J, Amadori S, Zweegman S, Sonneveld P. Phase II multicenter study of arsenic trioxide, ascorbic acid and dexamethasone in patients with relapsed or refractory multiple myeloma. Haematologica. 2006;91:1722–1723.
    • (2006) Haematologica , vol.91 , pp. 1722-1723
    • Wu, K.L.1    Beksac, M.2    Van Droogenbroeck, J.3    Amadori, S.4    Zweegman, S.5    Sonneveld, P.6
  • 29
    • 84905187637 scopus 로고    scopus 로고
    • Selective apoptosis of multiple myeloma cells in primary samples induced by arsenic trioxide
    • Rebersek K, Zontar DM, Cernelč P, Podgornik H. Selective apoptosis of multiple myeloma cells in primary samples induced by arsenic trioxide. Hematology. 2014;19(6):346–351.
    • (2014) Hematology , vol.19 , Issue.6 , pp. 346-351
    • Rebersek, K.1    Zontar, D.M.2    Cernelč, P.3    Podgornik, H.4
  • 30
    • 84880182936 scopus 로고    scopus 로고
    • Arsenic trioxide inhibits the hedgehog pathway which is aberrantly activated in acute promyelocytic leukemia
    • Yang D, Cao F, Ye X, et al. Arsenic trioxide inhibits the hedgehog pathway which is aberrantly activated in acute promyelocytic leukemia. Acta Haematol. 2013;130:260–267.
    • (2013) Acta Haematol , vol.130 , pp. 260-267
    • Yang, D.1    Cao, F.2    Ye, X.3
  • 31
    • 84885447093 scopus 로고    scopus 로고
    • The synergistic anti-tumor activity of arsenic trioxide and vitamin K2 in HL-60 cells involves increased ROS generation and regulation of the ROS-dependent MAPK signaling pathway
    • Qu H, Tong D, Zhang Y, Kang K, Chen L, Ren L. The synergistic anti-tumor activity of arsenic trioxide and vitamin K2 in HL-60 cells involves increased ROS generation and regulation of the ROS-dependent MAPK signaling pathway. Pharmazie. 2013;68:839–845.
    • (2013) Pharmazie , vol.68 , pp. 839-845
    • Qu, H.1    Tong, D.2    Zhang, Y.3    Kang, K.4    Chen, L.5    Ren, L.6
  • 32
    • 84903471531 scopus 로고    scopus 로고
    • Neuroprotective effect of resveratrol on arsenic trioxide-induced oxidative stress in feline brain
    • Cheng Y, Xue J, Jiang H, et al. Neuroprotective effect of resveratrol on arsenic trioxide-induced oxidative stress in feline brain. Hum Exp Toxicol. 2013;33(7):737–747.
    • (2013) Hum Exp Toxicol , vol.33 , Issue.7 , pp. 737-747
    • Cheng, Y.1    Xue, J.2    Jiang, H.3
  • 33
  • 34
    • 0032984589 scopus 로고    scopus 로고
    • Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells
    • Catlett-Falcone R, Landowski TH, Oshiro MM, et al. Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. Immunity. 1999;10:105–115.
    • (1999) Immunity , vol.10 , pp. 105-115
    • Catlett-Falcone, R.1    Landowski, T.H.2    Oshiro, M.M.3
  • 35
    • 0031984216 scopus 로고    scopus 로고
    • BCL-X expression in multiple myeloma: Possible indicator of chemoresistance
    • Tu Y, Renner S, Xu F, et al. BCL-X expression in multiple myeloma: possible indicator of chemoresistance. Cancer Res. 1998;58:256–262.
    • (1998) Cancer Res , vol.58 , pp. 256-262
    • Tu, Y.1    Renner, S.2    Xu, F.3
  • 36
    • 0031985198 scopus 로고    scopus 로고
    • Multiple myeloma: Increasing evidence for a multistep transformation process
    • Hallek M, Bergsagel PL, Anderson KC. Multiple myeloma: increasing evidence for a multistep transformation process. Blood. 1998;91: 3–21.
    • (1998) Blood , vol.91 , pp. 3-21
    • Hallek, M.1    Bergsagel, P.L.2    Anderson, K.C.3
  • 37
    • 33744532339 scopus 로고    scopus 로고
    • Sustained activation of c-jun-N-terminal kinase plays a critical role in arsenic trioxide-induced cell apoptosis in multiple myeloma cell lines
    • Kajiguchi T, Yamamoto K, Iida S, Ueda R, Emi N, Naoe T. Sustained activation of c-jun-N-terminal kinase plays a critical role in arsenic trioxide-induced cell apoptosis in multiple myeloma cell lines. Cancer Sci. 2006;97:540–545.
    • (2006) Cancer Sci , vol.97 , pp. 540-545
    • Kajiguchi, T.1    Yamamoto, K.2    Iida, S.3    Ueda, R.4    Emi, N.5    Naoe, T.6
  • 38
    • 73249129928 scopus 로고    scopus 로고
    • Enhanced antimyeloma cytotoxicity by the combination of arsenic trioxide and bortezomib is further potentiated by p38 MAPK inhibition
    • Wen J, Feng Y, Huang W, et al. Enhanced antimyeloma cytotoxicity by the combination of arsenic trioxide and bortezomib is further potentiated by p38 MAPK inhibition. Leuk Res. 2010;34:85–92.
    • (2010) Leuk Res , vol.34 , pp. 85-92
    • Wen, J.1    Feng, Y.2    Huang, W.3
  • 39
    • 37249084060 scopus 로고    scopus 로고
    • P38 MAPK inhibition enhancing ATO-induced cytotoxicity against multiple myeloma cells
    • Wen J, Cheng HY, Feng Y, et al. P38 MAPK inhibition enhancing ATO-induced cytotoxicity against multiple myeloma cells. Br J Haematol. 2008;140:169–180.
    • (2008) Br J Haematol , vol.140 , pp. 169-180
    • Wen, J.1    Cheng, H.Y.2    Feng, Y.3
  • 40
    • 0034680928 scopus 로고    scopus 로고
    • Inhibition of NF-kappa B activation by arsenite through reaction with a critical cysteine in the activation loop of Ikappa B kinase
    • Kapahi P, Takahashi T, Natoli G, et al. Inhibition of NF-kappa B activation by arsenite through reaction with a critical cysteine in the activation loop of Ikappa B kinase. J Biol Chem. 2000;275: 36062–36066.
    • (2000) J Biol Chem , vol.275 , pp. 36062-36066
    • Kapahi, P.1    Takahashi, T.2    Natoli, G.3
  • 41
    • 0035880256 scopus 로고    scopus 로고
    • Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration
    • Podar K, Tai YT, Davies FE, et al. Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration. Blood. 2001;98:428–435.
    • (2001) Blood , vol.98 , pp. 428-435
    • Podar, K.1    Tai, Y.T.2    Davies, F.E.3
  • 42
    • 0035921689 scopus 로고    scopus 로고
    • Biologic sequelae of interleukin-6 induced PI3-K/Akt signaling in multiple myeloma
    • Hideshima T, Nakamura N, Chauhan D, Anderson KC. Biologic sequelae of interleukin-6 induced PI3-K/Akt signaling in multiple myeloma. Oncogene. 2001;20:5991–6000.
    • (2001) Oncogene , vol.20 , pp. 5991-6000
    • Hideshima, T.1    Nakamura, N.2    Chauhan, D.3    Anderson, K.C.4
  • 43
    • 0036690367 scopus 로고    scopus 로고
    • Arsenic trioxide inhibits growth of human multiple myeloma cells in the bone marrow microenvironment
    • Hayashi T, Hideshima T, Akiyama M, et al. Arsenic trioxide inhibits growth of human multiple myeloma cells in the bone marrow microenvironment. Mol Cancer Ther. 2002;1:851–860.
    • (2002) Mol Cancer Ther , vol.1 , pp. 851-860
    • Hayashi, T.1    Hideshima, T.2    Akiyama, M.3
  • 44
    • 84907189650 scopus 로고    scopus 로고
    • Arsenic trioxide-based treatment of relapsed and refractory multiple myeloma
    • Zhang WJL, Bao S. Arsenic trioxide-based treatment of relapsed and refractory multiple myeloma. Chinese Community Physician. 2012;14:124–125.
    • (2012) Chinese Community Physician , vol.14 , pp. 124-125
    • Zhang, W.J.L.1    Bao, S.2
  • 45
    • 84907219217 scopus 로고    scopus 로고
    • Clinical efficiency of arsenic trioxide for the treatment of relapsed/refractory multiple myeloma
    • Yan JWB, Xue Z, Sun J, Song Z. Clinical efficiency of arsenic trioxide for the treatment of relapsed/refractory multiple myeloma. Journal of Clinical Hematology. 2004;17:207–208.
    • (2004) Journal of Clinical Hematology , vol.17 , pp. 207-208
    • Yan, J.W.B.1    Xue, Z.2    Sun, J.3    Song, Z.4
  • 46
    • 84860219808 scopus 로고    scopus 로고
    • A randomized phase 2 trial of a preparative regimen of bortezomib, high-dose melphalan, arsenic trioxide, and ascorbic acid
    • Sharma M, Khan H, Thall P F, et al. A randomized phase 2 trial of a preparative regimen of bortezomib, high-dose melphalan, arsenic trioxide, and ascorbic acid. Cancer. 2012;118:2507–2515.
    • (2012) Cancer , vol.118 , pp. 2507-2515
    • Sharma, M.1    Khan, H.2    Thall, P.F.3
  • 47
    • 18544376266 scopus 로고    scopus 로고
    • Vitamin C protects HL60 and U266 cells from arsenic toxicity
    • Karasavvas N, Carcamo JM, Stratis G, Golde DW. Vitamin C protects HL60 and U266 cells from arsenic toxicity. Blood. 2005;105: 4004–4012.
    • (2005) Blood , vol.105 , pp. 4004-4012
    • Karasavvas, N.1    Carcamo, J.M.2    Stratis, G.3    Golde, D.W.4
  • 48
    • 3142715479 scopus 로고    scopus 로고
    • Phase 2 study of arsenic trioxide in patients with relapsed or refractory multiple myeloma
    • Hussein MA, Saleh M, Ravandi F, Mason J, Rifkin RM, Ellison R. Phase 2 study of arsenic trioxide in patients with relapsed or refractory multiple myeloma. Br J Haematol. 2004;125:470–476.
    • (2004) Br J Haematol. , vol.125 , pp. 470-476
    • Hussein, M.A.1    Saleh, M.2    Ravandi, F.3    Mason, J.4    Rifkin, R.M.5    Ellison, R.6
  • 49
    • 67849098111 scopus 로고    scopus 로고
    • Phase II study of dexamethasone, ascorbic acid, thalidomide and arsenic trioxide (DATA) in high risk previously untreated (PU) and relapsed/refractory (RR) multiple myeloma (MM)
    • Baz RC, Kelly M, Reed J, et al. Phase II study of dexamethasone, ascorbic acid, thalidomide and arsenic trioxide (DATA) in high risk previously untreated (PU) and relapsed/refractory (RR) multiple myeloma (MM). J Clin Oncol. 2006;24:17535.
    • (2006) J Clin Oncol. , vol.24 , pp. 17535
    • Baz, R.C.1    Kelly, M.2    Reed, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.