Shiga toxin-producing Escherichia coli: A single-center, 11-year pediatric experience

Journal of Clinical Microbiology

Volumn 52, Issue 10, 2014, Pages 3647-3653

  Schindler, Emily I ^a,b   Sellenriek, Patricia ^c   Storch, Gregory A ^b   Tarr, Phillip I ^b   Burnham, Carey Ann D ^b  

^a BARNES JEWISH HOSPITAL   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c ST LOUIS CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SHIGA TOXIN; CULTURE MEDIUM;

ADOLESCENT; AEROMONAS; ARTICLE; BACTERIUM CULTURE; BACTERIUM DETECTION; BACTERIUM ISOLATE; CAMPYLOBACTER JEJUNI; CHILD; CLINICAL FEATURE; CONTROLLED STUDY; COST BENEFIT ANALYSIS; DIAGNOSTIC VALUE; DIARRHEA; EDWARDSIELLA TARDA; ENZYME IMMUNOASSAY; ESCHERICHIA COLI INFECTION; ESCHERICHIA COLI O157; FEMALE; HEALTH CARE COST; HEMOLYTIC UREMIC SYNDROME; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; NONHUMAN; PLESIOMONAS SHIGELLOIDES; RECTUM HEMORRHAGE; RETROSPECTIVE STUDY; SALMONELLA; SHIGA TOXIN PRODUCING ESCHERICHIA COLI; SHIGELLA; SORBITOL MACCONKEY AGAR CULTURE; YERSINIA ENTEROCOLITICA; CHEMISTRY; CULTURE MEDIUM; ESCHERICHIA COLI INFECTIONS; EVALUATION STUDY; FECES; HOSPITAL; ISOLATION AND PURIFICATION; MICROBIOLOGICAL EXAMINATION; MICROBIOLOGY; PRESCHOOL CHILD; PROCEDURES; SENSITIVITY AND SPECIFICITY; TERTIARY CARE CENTER;

ADOLESCENT; BACTERIOLOGICAL TECHNIQUES; CHILD; CHILD, PRESCHOOL; CULTURE MEDIA; DIARRHEA; ESCHERICHIA COLI INFECTIONS; FECES; FEMALE; HOSPITALS, PEDIATRIC; HUMANS; IMMUNOENZYME TECHNIQUES; INFANT; MALE; SENSITIVITY AND SPECIFICITY; SHIGA TOXIN; SHIGA-TOXIGENIC ESCHERICHIA COLI; TERTIARY CARE CENTERS;

EID: 84907178436     PISSN: 00951137     EISSN: 1098660X     Source Type: Journal    
DOI: 10.1128/JCM.01231-14     Document Type: Article

References (51)

1. Neill MA, Tarr PI, Clausen CR, Christie DL, Hickman RO. 1987. Escherichia coli O157:H7 as the predominant pathogen associated with the hemolytic uremic syndrome: a prospective study in the Pacific Northwest. Pediatrics 80:37-40.
2. Tarr PI, Gordon CA, Chandler WL. 2005. Shiga-toxin-producing Escherichia coli and haemolytic uraemic syndrome. Lancet 365:1073-1086. http://dx.doi.org/10.1016/S0140-6736(05)71144-2.
3. Karmali MA, Steele BT, Petric M, Lim C. 1983. Sporadic cases of haemolytic-uraemic syndrome associated with faecal cytotoxin and cytotoxin-producing Escherichia coli in stools. Lancet i:619-620.
4. Riley LW, Remis RS, Helgerson SD, McGee HB, Wells JG, Davis BR, Hebert RJ, Olcott ES, Johnson LM, Hargrett NT, Blake PA, Cohen ML. 1983. Hemorrhagic colitis associated with a rare Escherichia coli serotype. N. Engl. J. Med. 308:681-685. http://dx.doi.org/10.1056/NEJM19830324 3081203.
5. Bitzan M, Moebius E, Ludwig K, Muller-Wiefel DE, Heesemann J, Karch H. 1991. High incidence of serum antibodies to Escherichia coli O157 lipopolysaccharide in children with hemolytic-uremic syndrome. J. Pediatr. 119:380-385. http://dx.doi.org/10.1016/S0022-3476(05)82049-9.
6. Siegler RL, Pavia AT, Christofferson RD, Milligan MK. 1994. A 20-year population-based study of postdiarrheal hemolytic uremic syndrome in Utah. Pediatrics 94:35-40.
7. Griffin PM, Ostroff SM, Tauxe RV, Greene KD, Wells JG, Lewis JH, Blake PA. 1988. Illnesses associated with Escherichia coli O157:H7 infections: a broad clinical spectrum. Ann. Intern. Med. 109:705-712.
8. Gould LH, Demma L, Jones TF, Hurd S, Vugia DJ, Smith K, Shiferaw B, Segler S, Palmer A, Zansky S, Griffin PM. 2009. Hemolytic uremic syndrome and death in persons with Escherichia coli O157:H7 infection, Foodborne Diseases Active Surveillance Network sites, 2000-2006. Clin. Infect. Dis. 49:1480-1485. http://dx.doi.org/10.1086/644621.
9. Tarr PI, Neill MA, Clausen CR, Watkins SL, Christie DL, Hickman RO. 1990. Escherichia coli O157:H7 and the hemolytic uremic syndrome: importance of early cultures in establishing the etiology. J. Infect. Dis. 162: 553-556. http://dx.doi.org/10.1093/infdis/162.2.553.
10. Tapper D, Tarr P, Avner E, Brandt J, Waldhausen J. 1995. Lessons learned in the management of hemolytic uremic syndrome in children. J. Pediatr. Surg. 30:158-163. http://dx.doi.org/10.1016/0022-3468(95) 90554-5.
11. Rowe PC, Orrbine E, Lior H, Wells GA, Yetisir E, Clulow M, McLaine PN. 1998. Risk of hemolytic uremic syndrome after sporadic Escherichia coli O157:H7 infection: results of a Canadian collaborative study. J. Pediatr. 132:777-782.
12. Miceli S, Jure MA, de Saab OA, de Castillo MC, Rojas S, de Holgado AP, de Nader OM. 1999. A clinical and bacteriological study of children suffering from haemolytic uraemic syndrome in Tucuman, Argentina. Jpn. J. Infect. Dis. 52:33-37.
13. Banatvala N, Griffin PM, Greene KD, Barrett TJ, Bibb WF, Green JH, Wells JG, Hemolytic Uremic Syndrome Study Collaborators. 2001. The United States National Prospective Hemolytic Uremic Syndrome Study: microbiologic, serologic, clinical, and epidemiologic findings. J. Infect. Dis. 183:1063-1070. http://dx.doi.org/10.1086/319269.
14. Klein EJ, Stapp JR, Clausen CR, Boster DR, Wells JG, Qin X, Swerdlow DL, Tarr PI. 2002. Shiga toxin-producing Escherichia coli in children with diarrhea: a prospective point-of-care study. J. Pediatr. 141:172-177. http://dx.doi.org/10.1067/mpd.2002.125908.
15. Rivas M, Miliwebsky E, Chinen I, Roldan CD, Balbi L, Garcia B, Fiorilli G, Sosa-Estani S, Kincaid J, Rangel J, Griffin PM, Case-Control Study Group. 2006. Characterization and epidemiologic subtyping of Shiga toxin-producing Escherichia coli strains isolated from hemolytic uremic syndrome and diarrhea cases in Argentina. Foodborne Pathog. Dis. 3:88-96. http://dx.doi.org/10.1089/fpd.2006.3.88.
16. Gould LH, Bopp C, Strockbine N, Atkinson R, Baselski V, Body B, Carey R, Crandall C, Hurd S, Kaplan R, Neill M, Shea S, Somsel P, Tobin-DAngelo M, Griffin PM, Gerner-Smidt P. 2009. Recommendations for diagnosis of Shiga toxin-producing Escherichia coli infections by clinical laboratories. MMWR Recomm. Rep. 58(RR12):1-14.
17. Fey PD, Wickert RS, Rupp ME, Safranek TJ, Hinrichs SH. 2000. Prevalence of non-O157:H7 Shiga toxin-producing Escherichia coli in diarrheal stool samples from Nebraska. Emerg. Infect. Dis. 6:530-533. http://dx.doi.org/10.3201/eid0605.000513.
18. Carroll KC, Adamson K, Korgenski K, Croft A, Hankemeier R, Daly J, Park CH. 2003. Comparison of a commercial reversed passive latex agglutination assay to an enzyme immunoassay for the detection of Shiga toxin-producing Escherichia coli. Eur. J. Clin. Microbiol. Infect. Dis. 22: 689-692. http://dx.doi.org/10.1007/s10096-003-1053-9.
19. Lockary VM, Hudson RF, Ball CL. 2007. Shiga toxin-producing Escherichia coli, Idaho. Emerg. Infect. Dis. 13:1262-1264. http://dx.doi.org/10 .3201/eid1308.070189.
20. Church DL, Emshey D, Semeniuk H, Lloyd T, Pitout JD. 2007. Evaluation of BBL CHROMagar O157 versus sorbitol-MacConkey medium for routine detection of Escherichia coli O157 in a centralized regional clinical microbiology laboratory. J. Clin. Microbiol. 45:3098-3100. http://dx.doi .org/10.1128/JCM.00426-07.
21. Denno DM, Shaikh N, Stapp JR, Qin X, Hutter CM, Hoffman V, Mooney JC, Wood KM, Stevens HJ, Jones R, Tarr PI, Klein EJ. 2012. Diarrhea etiology in a pediatric emergency department: a case control study. Clin. Infect. Dis. 55:897-904. http://dx.doi.org/10.1093/cid/cis553.
22. Park CH, Kim HJ, Hixon DL, Bubert A. 2003. Evaluation of the Duopath verotoxin test for detection of Shiga toxins in cultures of human stools. J. Clin. Microbiol. 41:2650-2653. http://dx.doi.org/10.1128/JCM.41.6.2650-2653.2003.
23. Teel LD, Daly JA, Jerris RC, Maul D, Svanas G, OBrien AD, Park CH. 2007. Rapid detection of Shiga toxin-producing Escherichia coli by optical immunoassay. J. Clin. Microbiol. 45:3377-3380. http://dx.doi.org/10 .1128/JCM.00837-07.
24. Manning SD, Madera RT, Schneider W, Dietrich SE, Khalife W, Brown W, Whittam TS, Somsel P, Rudrik JT. 2007. Surveillance for Shiga toxin-producing Escherichia coli, Michigan, 2001-2005. Emerg. Infect. Dis. 13:318-321. http://dx.doi.org/10.3201/eid1302.060813.
25. Gould LH, Mody RK, Ong KL, Clogher P, Cronquist AB, Garman KN, Lathrop S, Medus C, Spina NL, Webb TH, White PL, Wymore K, Gierke RE, Mahon BE, Griffin PM, Emerging Infections Program FoodNet Working Group. 2013. Increased recognition of non-O157 Shiga toxin-producing Escherichia coli infections in the United States during 2000-2010: epidemiologic features and comparison with E. coli O157 infections. Foodborne Pathog. Dis. 10:453-460. http://dx.doi.org/10 .1089/fpd.2012.1401.
26. Ake JA, Jelacic S, Ciol MA, Watkins SL, Murray KF, Christie DL, Klein EJ, Tarr PI. 2005. Relative nephroprotection during Escherichia coli O157:H7 infections: association with intravenous volume expansion. Pediatrics 115:e673-e680. http://dx.doi.org/10.1542/peds.2004-2236.
27. Kiska DL, Riddell SW. 2011. Counterpoint: should all stools be screened for Shiga toxin-producing Escherichia coli? J. Clin. Microbiol. 49:2394-2397. http://dx.doi.org/10.1128/JCM.00817-11.
28. Johnson KE, Thorpe CM, Sears CL. 2006. The emerging clinical importance of non-O157 Shiga toxin-producing Escherichia coli. Clin. Infect. Dis. 43:1587-1595. http://dx.doi.org/10.1086/509573.
29. Mead PS, Griffin PM. 1998. Escherichia coli O157:H7. Lancet 352:1207-1212. http://dx.doi.org/10.1016/S0140-6736(98)01267-7.
30. Hoefer D, Hurd S, Medus C, Cronquist A, Hanna S, Hatch J, Hayes T, Larson K, Nicholson C, Wymore K, Tobin-DAngelo M, Strockbine N, Snippes P, Atkinson R, Griffin PM, Gould LH. 2011. Laboratory practices for the identification of Shiga toxin-producing Escherichia coli in the United States, FoodNet sites, 2007. Foodborne Pathog. Dis. 8:555-560. http://dx.doi.org/10.1089/fpd.2010.0764.
31. Cornick NA, Jelacic S, Ciol MA, Tarr PI. 2002. Escherichia coli O157:H7 infections: discordance between filterable fecal Shiga toxin and disease outcome. J. Infect. Dis. 186:57-63. http://dx.doi.org/10.1086/341295.
32. Chandler WL, Jelacic S, Boster DR, Ciol MA, Williams GD, Watkins SL, Igarashi T, Tarr PI. 2002. Prothrombotic coagulation abnormalities preceding the hemolytic-uremic syndrome. N. Engl. J. Med. 346:23-32. http://dx.doi.org/10.1056/NEJMoa011033.
33. Gavin PJ, Peterson LR, Pasquariello AC, Blackburn J, Hamming MG, Kuo KJ, Thomson RB, Jr. 2004. Evaluation of performance and potential clinical impact of ProSpecT Shiga toxin Escherichia coli microplate assay for detection of Shiga toxin-producing E. coli in stool samples. J. Clin. Microbiol. 42:1652-1656. http://dx.doi.org/10.1128/JCM.42.4.1652-1656 .2004.
34. Cohen MB. 2002. Shiga toxin-producing E coli: two tests are better than one. J. Pediatr. 141:155-156. http://dx.doi.org/10.1067/mpd.2002.126920.
35. Hermos CR, Janineh M, Han LL, McAdam AJ. 2011. Shiga toxinproducing Escherichia coli in children: diagnosis and clinical manifestations of O157:H7 and non-O157:H7 infection. J. Clin. Microbiol. 49:955-959. http://dx.doi.org/10.1128/JCM.02119-10.
36. CDC. 2012. Foodborne Diseases Active Surveillance Network (FoodNet): FoodNet surveillance report for 2011 (final report). CDC, Atlanta, GA.
37. Slutsker L, Ries AA, Greene KD, Wells JG, Hutwagner L, Griffin PM. 1997. Escherichia coli O157:H7 diarrhea in the United States: clinical and epidemiologic features. Ann. Intern. Med. 126:505-513. http://dx.doi.org/10.7326/0003-4819-126-7-199704010-00002.
38. Hickey CA, Beattie TJ, Cowieson J, Miyashita Y, Strife CF, Frem JC, Peterson JM, Butani L, Jones DP, Havens PL, Patel HP, Wong CS, Andreoli SP, Rothbaum RJ, Beck AM, Tarr PI. 2011. Early volume expansion during diarrhea and relative nephroprotection during subsequent hemolytic uremic syndrome. Arch. Pediatr. Adolesc. Med. 165: 884-889. http://dx.doi.org/10.1001/archpediatrics.2011.152.
39. Mody RK, Luna-Gierke RE, Jones TF, Comstock N, Hurd S, Scheftel J, Lathrop S, Smith G, Palmer A, Strockbine N, Talkington D, Mahon BE, Hoekstra RM, Griffin PM. 2012. Infections in pediatric postdiarrheal hemolytic uremic syndrome: factors associated with identifying Shiga toxin-producing Escherichia coli. Arch. Pediatr. Adolesc. Med. 166:902-909. http://dx.doi.org/10.1001/archpediatrics.2012.471.
40. Espie E, Grimont F, Mariani-Kurkdjian P, Bouvet P, Haeghebaert S, Filliol I, Loirat C, Decludt B, Minh NN, Vaillant V, de Valk H. 2008. Surveillance of hemolytic uremic syndrome in children less than 15 years of age, a system to monitor O157 and non-O157 Shiga toxin-producing Escherichia coli infections in France, 1996-2006. Pediatr. Infect. Dis. J. 27:595-601. http://dx.doi.org/10.1097/INF.0b013e31816a062f.
41. Chart H, Cheasty T. 2008. Human infections with verocytotoxinproducing Escherichia coli O157: 10 years of E. coli O157 serodiagnosis. J. Med. Microbiol. 57:1389-1393. http://dx.doi.org/10.1099/jmm.0.2008/003632-0.
42. Bitzan M, Ludwig K, Klemt M, Konig H, Buren J, Muller-Wiefel DE. 1993. The role of Escherichia coli O 157 infections in the classical (enteropathic) haemolytic uraemic syndrome: results of a Central European, multicentre study. Epidemiol. Infect. 110:183-196. http://dx.doi.org/10 .1017/S0950268800068102.
43. Chart H, Smith HR, Scotland SM, Rowe B, Milford DV, Taylor CM. 1991. Serological identification of Escherichia coli O157:H7 infection in haemolytic uraemic syndrome. Lancet 337:138-140. http://dx.doi.org/10 .1016/0140-6736(91)90801-U.
44. Rasko DA, Webster DR, Sahl JW, Bashir A, Boisen N, Scheutz F, Paxinos EE, Sebra R, Chin CS, Iliopoulos D, Klammer A, Peluso P, Lee L, Kislyuk AO, Bullard J, Kasarskis A, Wang S, Eid J, Rank D, Redman JC, Steyert SR, Frimodt-Moller J, Struve C, Petersen AM, Krogfelt KA, Nataro JP, Schadt EE, Waldor MK. 2011. Origins of the E. coli strain causing an outbreak of hemolytic-uremic syndrome in Germany. N. Engl. J. Med. 365:709-717. http://dx.doi.org/10.1056/NEJMoa1106920.
45. Loos S, Ahlenstiel T, Kranz B, Staude H, Pape L, Hartel C, Vester U, Buchtala L, Benz K, Hoppe B, Beringer O, Krause M, Muller D, Pohl M, Lemke J, Hillebrand G, Kreuzer M, Konig J, Wigger M, Konrad M, Haffner D, Oh J, Kemper MJ. 2012. An outbreak of Shiga toxinproducing Escherichia coli O104:H4 hemolytic uremic syndrome in Germany: presentation and short-term outcome in children. Clin. Infect. Dis. 55:753-759. http://dx.doi.org/10.1093/cid/cis531.
46. Preussel K, Hohle M, Stark K, Werber D. 2013. Shiga toxin-producing Escherichia coli O157 is more likely to lead to hospitalization and death than non-O157 serogroups-except O104. PLoS One 8:e78180. http://dx .doi.org/10.1371/journal.pone.0078180.
47. Loman NJ, Constantinidou C, Christner M, Rohde H, Chan JZ, Quick J, Weir JC, Quince C, Smith GP, Betley JR, Aepfelbacher M, Pallen MJ. 2013. A culture-independent sequence-based metagenomics approach to the investigation of an outbreak of Shiga-toxigenic Escherichia coli O104: H4. JAMA 309:1502-1510. http://dx.doi.org/10.1001/jama.2013.3231.
48. Teel LD, Steinberg BR, Aronson NE, OBrien AD. 2003. Shiga toxinproducing Escherichia coli-associated kidney failure in a 40-year-old patient and late diagnosis by novel bacteriologic and toxin detection methods. J. Clin. Microbiol. 41:3438-3440. http://dx.doi.org/10.1128/JCM.41 .7.3438-3440.2003.
49. European Food Safety Authority, European Centre for Disease Prevention and Control. 2012. The European Union summary report on trends and sources of zoonoses, zoonotic agents and food-borne outbreaks in 2010. EFSA J. 10:2597. http://dx.doi.org/10.2903/j.efsa.2012.2597.
50. Balestracci A, Martin SM, Toledo I, Alvarado C, Wainsztein RE. 2012. Dehydration at admission increased the need for dialysis in hemolytic uremic syndrome children. Pediatr. Nephrol. 27:1407-1410. http://dx.doi .org/10.1007/s00467-012-2158-0.
51. Ojeda JM, Kohout I, Cuestas E. 2013. Dehydration upon admission is a risk factor for incomplete recovery of renal function in children with haemolytic uremic syndrome. Nefrologia 33:372-376. http://dx.doi.org/10 .3265/Nefrologia.pre2012.Nov.11648.