Isolation and analysis of ketoconazole resistant mutants of saccharomyces cerevisiae

Medical Mycology

Volumn 26, Issue 3, 1988, Pages 153-162

  Watson, P F ^a   Rose, M E ^b   Kelly, S L ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b SHEFFIELD HALLAM UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

KETOCONAZOLE;

BIOLOGICAL MODEL; BIOSYNTHESIS; DEMETHYLATION; DRUG RESISTANCE; FUNGUS; GENETIC ENGINEERING; METHODOLOGY; MUTATION; NONHUMAN; SACCHAROMYCES CEREVISIAE;

CYTOCHROME P-450 ENZYME SYSTEM; DRUG RESISTANCE, MICROBIAL; ERGOSTEROL; GENETIC COMPLEMENTATION TEST; KETOCONAZOLE; MASS FRAGMENTOGRAPHY; MICROBIAL SENSITIVITY TESTS; MUTATION; SACCHAROMYCES CEREVISIAE; SPECTROPHOTOMETRY, ULTRAVIOLET; SUPPORT, NON-U.S. GOV'T;

EID: 84907135003     PISSN: 13693786     EISSN: None     Source Type: Journal    
DOI: 10.1080/02681218880000231     Document Type: Article

References (22)

1. Altered cytochrome P-450 in a yeast mutant blocked in demethylating C-32 of lanosterol
2. Biosynthesis of terpenes and steroids IX. The sterols of some mutant yeasts and their relationship to the biosynthesis of ergosterol
3. Microscopic studies of Candida albicans and Torulopsis glabrata after in vitro treatment with bifonazole. Light and scanning electron microscopy
4. Sterol structure and membrane function
5. Chemotherapeutic and agrochemical applications of cytochrome P-450 ligands
6. Yeast mutants requiring ergosterol as only lipid supplement
7. The lipid composition of azole-sensitive and azole-resistant strains of Candida albicans
8. The lipid composition and permeability to azole of an azole- and polyene-resistant mutant of Candida albicans
9. Differences in cytochrome P-450 enzymes of sterol C-14 demethylase mutants of Saccharomyces cerevisiae
10. Polyene resistance and the isolation of sterol mutants in Saccharomyces cerevisiae
11. Metabolism of 24-sterols by yeast mutants blocked in removal of the C-14 methyl group
12. Mitochondrial resistance to miconazole in Saccharomyces cerevisiae
13. Azole resistance in Candida albicans
14. Azole resistance in Candida albicans
15. Heterogeneity of action mechanisms among antimycotic imidazoles
16. Requirement for second sterol biosynthetic mutation for viability of a sterol C-14 demethylation defect in Saccharomyces cerevisiae
17. Yeast mutants blocked in removing the methyl group of lanosterol at C-14. Separation of sterols by high pressure liquid chromatography
18. Biochemical targets for antifungal azole derivatives: hypothesis on the mode of action
19. Modified response to ketoconazole of Candida albicans from a treatment failure
20. Relationship of cytochrome P-450 to growth phase of brewer's yeast in 1% or 20% glucose medium
21. Nystatin resistant mutants of yeast; alterations in sterol content