GAL-021, a new intravenous BKCa-channel blocker, is well tolerated and stimulates ventilation in healthy volunteers

British Journal of Anaesthesia

Volumn 113, Issue 5, 2014, Pages 875-883

  McLeod, J F ^a   Leempoels, J M ^b   Peng, S X ^a   Dax, S L ^a   Myers, L J ^c   Golder, F J ^a  

^a Galleon Pharmaceuticals   (United States)

^b SGS Life Science Services   (Belgium)

^c Vivonoetics   (United States)

Author keywords

BKCa channel; breathing; carotid body; EudraCT: 2011 003371 11; KCNMA1; pharmacokinetics; potassium channel; respiratory stimulant; ventilatory function

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; GAL 021; PLACEBO; UNCLASSIFIED DRUG; CARBON DIOXIDE; GAL021; KCNMA1 PROTEIN, HUMAN; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL ALPHA SUBUNIT; POTASSIUM CHANNEL BLOCKING AGENT; TRIAZINE DERIVATIVE;

ABDOMINAL PAIN; ADULT; AREA UNDER THE CURVE; ARTICLE; BURNING SENSATION; COMMON COLD; CONTROLLED STUDY; COUGHING; CROSSOVER PROCEDURE; DIASTOLIC BLOOD PRESSURE; DISTRIBUTION HALF-LIFE; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DOSE ESCALATION; DRUG HALF LIFE; DRUG INDUCED HEADACHE; DRUG SAFETY; DRUG TOLERABILITY; END TIDAL CARBON DIOXIDE TENSION; FAINTNESS; FEMALE; FIRST IN HUMAN STUDY; HEART ARRHYTHMIA; HEART RATE; HUMAN; HUMAN EXPERIMENT; HYPERVENTILATION; INFUSION RATE; INFUSION RELATED REACTION; LOADING DRUG DOSE; LOOSE FECES; LUNG MINUTE VOLUME; MAINTENANCE DRUG DOSE; MALE; MAXIMUM PLASMA CONCENTRATION; MEAN ARTERIAL PRESSURE; NAUSEA; NORMAL HUMAN; PANEL STUDY; PATIENT MONITOR; PLASMA CONCENTRATION-TIME CURVE; PLETHYSMOGRAPH; PNEUMOTACHOMETER; RANDOMIZED CONTROLLED TRIAL; RHINITIS; RHINOPHARYNGITIS; SIDE EFFECT; SYSTOLIC BLOOD PRESSURE; TIDAL VOLUME; TIME TO MAXIMUM PLASMA CONCENTRATION; VEIN INJURY; VOLUME OF DISTRIBUTION; VOLUME OF DISTRIBUTION AT STEADY-STATE; ANTAGONISTS AND INHIBITORS; BLOOD; BREATHING MECHANICS; DRUG EFFECTS; INTRAVENOUS DRUG ADMINISTRATION; YOUNG ADULT;

ADULT; CARBON DIOXIDE; CROSS-OVER STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INFUSIONS, INTRAVENOUS; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA SUBUNITS; MALE; POTASSIUM CHANNEL BLOCKERS; RESPIRATORY MECHANICS; TRIAZINES; YOUNG ADULT;

EID: 84907052588     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/aeu182     Document Type: Article

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