Two studies on reversal of opioid-induced respiratory depression by BK-channel blocker GAL021 in human volunteers

Anesthesiology

Volumn 121, Issue 3, 2014, Pages 459-468

  Roozekrans, Margot ^a   Van Der Schrier, Rutger ^a   Okkerse, Pieter ^b   Hay, Justin ^b   McLeod, James F ^c   Dahan, Albert ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b CENTRE FOR HUMAN DRUG RESEARCH   (Netherlands)

^c Galleon Pharmaceuticals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALFENTANIL; CALCIUM CHANNEL BLOCKING AGENT; GAL 021; PLACEBO; UNCLASSIFIED DRUG; DOXAPRAM; GAL021; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; NARCOTIC ANALGESIC AGENT; POTASSIUM CHANNEL BLOCKING AGENT; TRIAZINE DERIVATIVE;

ADULT; ANALGESIA; ANTINOCICEPTION; BREATHING; BREATHING RATE; CARBON DIOXIDE TENSION; CONFERENCE PAPER; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG INDUCED HEADACHE; DRUG MEGADOSE; DRUG SAFETY; EXPLORATORY RESEARCH; HALLUCINATION; HEART OUTPUT; HEART RATE; HEMODYNAMICS; HUMAN; HUMAN EXPERIMENT; INJECTION SITE PAIN; ISOHYPERCAPNIA; LIMB WEAKNESS; LOADING DRUG DOSE; LOW DRUG DOSE; LUNG MINUTE VOLUME; LUNG VENTILATION; MALE; MEAN ARTERIAL PRESSURE; NAUSEA; NORMAL HUMAN; OXYGEN SATURATION; PAIN THRESHOLD; POIKILOCAPNIA; PRIORITY JOURNAL; PRURITUS; RANDOMIZED CONTROLLED TRIAL; RESPIRATION DEPRESSION; SEDATION; SIDE EFFECT; SWEATING; TIDAL VOLUME; ADOLESCENT; ANTAGONISTS AND INHIBITORS; CHEMICALLY INDUCED; DRUG EFFECTS; MIDDLE AGED; RESPIRATORY INSUFFICIENCY;

ADOLESCENT; ADULT; ALFENTANIL; ANALGESIA; ANALGESICS, OPIOID; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; DOXAPRAM; HEALTHY VOLUNTEERS; HEMODYNAMICS; HUMANS; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MALE; MIDDLE AGED; POTASSIUM CHANNEL BLOCKERS; RESPIRATORY INSUFFICIENCY; TRIAZINES;

EID: 84907047119     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/ALN.0000000000000367     Document Type: Conference Paper

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