Stand up for health - Avoiding sedentary behaviour might lengthen your telomeres: Secondary outcomes from a physical activity RCT in older people

British Journal of Sports Medicine

Volumn 48, Issue 19, 2014, Pages 1407-1409

  Sjögren, Per ^a   Fisher, Rachel ^b   Kallings, Lena ^c   Svenson, Ulrika ^d   Roos, Göran ^d   Hellénius, Mai Lis ^e  

^a UPPSALA UNIVERSITY   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c SWEDISH SCHOOL OF SPORT AND HEALTH SCIENCES   (Sweden)

^d UMEÅ UNIVERSITY   (Sweden)

^e KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

AGED; BLOOD CELL; CONTROLLED STUDY; EXERCISE; FEMALE; HUMAN; MALE; OBESITY; PATHOPHYSIOLOGY; PHYSIOLOGY; PILOT STUDY; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SEDENTARY LIFESTYLE; TELOMERE HOMEOSTASIS; ULTRASTRUCTURE;

AGED; BLOOD CELLS; EXERCISE; FEMALE; HUMANS; MALE; OVERWEIGHT; PILOT PROJECTS; PROSPECTIVE STUDIES; SEDENTARY LIFESTYLE; TELOMERE HOMEOSTASIS;

EID: 84907044504     PISSN: 03063674     EISSN: 14730480     Source Type: Journal    
DOI: 10.1136/bjsports-2013-093342     Document Type: Article

References (27)

1. Lin J, Epel E, Blackburn E. Telomeres and lifestyle factors: roles in cellular aging. Mutat Res 2012;730:85-9.
2. Mirabello L, Huang WY, Wong JY, et al. The association between leukocyte telomere length and cigarette smoking, dietary and physical variables, and risk of prostate cancer. Aging Cell 2009;8:405-13.
3. Paul L. Diet, nutrition and telomere length. J Nutr Biochem 2011;22:895-901.
4. Cherkas LF, Hunkin JL, Kato BS, et al. The association between physical activity in leisure time and leukocyte telomere length. Arch Intern Med 2008;28:154-8.
5. Krauss J, Farzaneh-Far R, Puterman E, et al. Physical fitness and telomere length in patients with coronary heart disease: findings from the Heart and Soul Study. PLoS ONE 2011;6:e26983.
6. Kim JH, Ko JH, Lee DC, et al. Habitual physical exercise has beneficial effects on telomere length in postmenopausal women. Menopause 2012;19:1109-15.
7. Østhus IB, Sgura A, Berardinelli F, et al. Telomere length and long-term endurance exercise: does exercise training affect biological age? A pilot study. PLoS ONE 2012;7:e52769.
8. Denham J, Nelson CP, O'Brien BJ, et al. Longer leukocyte telomeres are associated with ultra-endurance exercise independent of cardiovascular risk factors. PLoS ONE 2013;8:e69377.
9. Ponsot E, Lexell J, Kadi F. Skeletal muscle telomere length is not impaired in healthy physically active old women and men. Muscle Nerve 2008;37:467-72.
10. Savela S, Saijonmaa O, Strandberg TE, et al. Physical activity in midlife and telomere length measured in old age. Exp Gerontol 2013;48:81-4.
11. Blackburn EH, Epel ES. Telomeres and adversity: Too toxic to ignore. Nature 2012;11:169-71.
12. Wolkowitz OM, Mellon SH, Epel ES, et al. Leukocyte telomere length in major depression: correlations with chronicity, inflammation and oxidative stress - preliminary findings. PLoS ONE 2011;6:e17837.
13. Puterman E, Lin J, Blackburn E, et al. The power of exercise: buffering the effect of chronic stress on telomere length. PLoS ONE 2010;5:e10837.
14. Kallings LV, Sierra Johnson J, Fisher RM, et al. Beneficial effects of individualized physical activity on prescription on body composition and cardiometabolic risk factors: results from a randomized controlled trial. Eur J Cardiovasc Prev Rehabil 2009;16:80-4.
15. Svenson U, Nordfjäll K, Baird D, et al. Blood cell telomere length is a dynamic feature. PLoS ONE 2011;6:e21485.
16. Lee IM, Shiroma EJ, Lobelo F, et al. Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy. Lancet 2012;380:219-29.
17. Hallal PC, Andersen LB, Bull FC, et al. Physical Activity Series Working Group. Global physical activity levels: surveillance progress, pitfalls, and prospects. Lancet 2012;380:247-57.
18. Ekblom-Bak E, Hellénius ML, Ekblom B. Are we facing a new paradigm of inactivity physiology? Br J Sports Med 2010;44:834-5.
19. Dunstan DW, Howard B, Healy GN, et al. Too much sitting - a health hazard. Diabetes Res Clin Pract 2012;97:368-76.
20. Wilmot EG, Edwardson CL, Achana FA, et al. Sedentary time in adults and the association with diabetes, cardiovascular disease and death: systematic review and meta-analysis. Diabetologia 2012;55:2895-905.
21. Healy GN, Matthews CE, Dunstan DW, et al. Sedentary time and cardio-metabolic biomarkers in US adults: NHANES 2003-06. Eur Heart J 2011;32:590-7.
22. Dunstan DW, Kingwell BA, Larsen R, et al. Breaking up prolonged sitting reduces postprandial glucose and insulin responses. Diabetes Care 2012;35:976-83.
23. Duvivier BM, Schaper NC, Bremers MA, et al. Minimal intensity physical activity (standing and walking) of longer duration improves insulin action and plasma lipids more than shorter periods of moderate to vigorous exercise (cycling) in sedentary subjects when energy expenditure is comparable. PLoS ONE 2013;8:e55542
24. Howard BJ, Fraser SF, Sethi P, et al. Impact on hemostatic parameters of interrupting sitting with intermittent activity. Med Sci Sports Exerc 2013;45:1285-91.
25. Tuomilehto J, Lindström J, Eriksson JG, et al.; Finnish Diabetes Prevention Study Group. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 2001;344:1343-50.
26. Hovatta I, de Mello VD, Kananen L, et al. Leukocyte telomere length in the Finnish Diabetes Prevention Study. PLoS ONE 2012;7:e34948.
27. Latouche C, Jowett JB, Carey AL, et al. Effects of breaking up prolonged sitting on skeletal muscle gene expression. J Appl Physiol 2013;114:4.