The effect of adenotonsilectomy on ghrelin, leptin, IGF-1 levels and growth parameters in children with adenotonsillar hypertrophy

Journal of Pediatric Endocrinology and Metabolism

Volumn 27, Issue 9-10, 2014, Pages 885-890

  Salman, Nergis ^a   Ozturk, Gulfer ^b   Akin, Istemihan ^b   Kilicaslan, Saffet ^c   Demirel, Fatma ^a   Delibas, Namik ^b  

^a Ankara Child Diseases Hematology Oncology Training and Research Hospital   (Turkey)

^b DISKAPI YILDIRIM BEYAZIT TRAINING AND RESEARCH HOSPITAL   (Turkey)

^c Sanliurfa Training and Research Hospital   (Turkey)

Author keywords

adenotonsillar hypertrophy; children; ghrelin; IGF 1; leptin

Indexed keywords

GHRELIN; LEPTIN; SOMATOMEDIN C;

ADENOTONSILLAR HYPERTROPHY; ADENOTONSILLECTOMY; ARTICLE; BODY HEIGHT; BODY MASS; BODY WEIGHT; CACHEXIA; CHILD; CHILD GROWTH; CLINICAL ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; FOOD INTAKE; HORMONE BLOOD LEVEL; HUMAN; MALNUTRITION; POSTOPERATIVE PERIOD; PREOPERATIVE EVALUATION; SLEEP DISORDERED BREATHING; ADENOID; ADENOIDECTOMY; BLOOD; FEMALE; HYPERPLASIA; HYPERTROPHY; MALE; METABOLISM; PALATINE TONSIL; PATHOLOGY; PHYSIOLOGY; PRESCHOOL CHILD; SURGERY; TONSILLECTOMY;

ADENOIDECTOMY; ADENOIDS; BODY HEIGHT; CHILD; CHILD, PRESCHOOL; FEMALE; GHRELIN; HUMANS; HYPERPLASIA; HYPERTROPHY; INSULIN-LIKE GROWTH FACTOR I; LEPTIN; MALE; PALATINE TONSIL; TONSILLECTOMY;

EID: 84906983499     PISSN: 0334018X     EISSN: 21910251     Source Type: Journal    
DOI: 10.1515/jpem-2013-0367     Document Type: Article

References (37)

1. Williams EF, Woo P, Miller R, Kellman RM. The effects of adenotonsillectomy on growth in young children. Otolaryngol Head Neck Surg 1991;104:509-16.
2. Bar A, Tarasiuk A, Segev Y, Phillip M, Tal A. The effect of adenotonsillectomy on serum insulin-like growth factor-I and growth in children with obstructive sleep apnea syndrome. J Pediatr 1999;135:76-80.
3. Gozal D. Sleep-disordered breathing and school performance in children. Pediatrics 1998;102(3 Pt 1):616-20. 10.1542/peds.102.3.616
4. Shintani T, Asakura K, Kataura A. The effect of adenotonsillectomy in children with OSA. Int J Pediatr Otorhinolaryngol 1998;44:51-8.
5. Bock A, Popp W, Herkner KR. Tonsillectomy and the immune system: a longterm follow up comparison between tonsillectomized and non-tonsillectomized children. Eur Arch Otorhinolaryngol 1994;251:423-7.
6. Blum WF, Albertsson-Wikland K, Rosberg S, Ranke MB. Serum levels of insulin-like growth factor I (IGF-I) and IGF binding protein 3 reflect spontaneous growth hormone secretion. J Clin Endocrinol Metab 1993;76:1610-6.
7. Yilmaz MD, Hosal AS, Oguz H, Yordam N, Kaya S. The effects of tonsillectomy on serum IGF-I and IGFBP3 levels in children. Laryngoscope 2002;112:922-5.
8. Selimoglu E, Selimoglu MA, Orbak Z. Does adenotonsillectomy improve growth in children with obstructive adenotonsillar hypertrophy J Int Med Res 2003;31:84-7. 1276031110.1177/147323000303100204
9. Ozen A, Furman A, Berber M, Karatepe HO, Mutlu N, et al. The effect of Helicobacter pyloriand economic status on growth parameters and leptin, ghrelin, and insulin-like growth factor (IGF)-I concentrations in children. Helicobacter 2011;16:55-65. 10.1111/j.1523-5378.2010.00814.xhttp://gateway.webofknowledge.com/gateway/Gateway.cgiGWVersion=2&SrcApp=PARTNER-APP&SrcAuth=LinksAMR&KeyUT=000286226400010&DestLinkType=FullRecord&DestApp=ALL-WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3
10. Van Der Lely AJ, Tschop M, Heiman ML, Ghigo E. Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr Rev 2004;25:426-57.
11. Nakazato M, Murakami N, Date Y, Kojima M, Matsuo H, et al. A role for ghrelin in the central regulation of feeding. Nature 2001;409:194-8.
12. Wasilewska J, Kaczmarski M, Debkowska K. Obstructive hypopnea and astroesophageal reflux as factors associated with residual obstructive sleep apnea syndrome. Int J Pediatr Otorhinolaryngol 2011;75:657-63.
13. Kojima M, Kanagawa K. Ghrelin: structure and function. Physiol Rev 2005;85:495-522. 10.1152/physrev.00012.200415788704
14. Konturek SJ, Konturek JW, Pawlik T, Brzozowski T. Brain-gut axis and its role in the control of food intake. J Physiol Pharmacol 2004;55(1 Pt 2):137-54.
15. Peters JH, McKay BM, Simasko SM, Ritter RC. Leptin-induced satiation mediated by abdominal vagal afferent. Am J Physiol Regul Integr Comp Physiol 2005;288:879-84.
16. Ohlsson C, Bengstsson BA, Isaksson OG, Andreassen TT, Slootwag MC. Growth hormone and bone. Endocrinology 1998;19:55-79.
17. Daughaday WH, Rotwein P, Insulin-like growth factors I and II. Peptide, messenger ribonucleic acid and gene structures, serum, and tissue concentrations. Endocrinology 1989;10:69-91.
18. Bouhaddioui L, Brun JF, Jacquemin JL, Bailly A, Bouhaddioui N, et al. Immunoreactive somatomedin C in children from Morocco: a biological marker of nutritional growth retardation Biomed Pharmacother 1989;43:59-63.
19. Beaune B, Blonc S, Fellmann N, Bedu M, Coudert J. Serum insulin-like growth factor I and physical performance in prepubertal Bolivian girls of a high and low socio-economic status. Eur J Appl Physiol 1996;76:98-102.
20. Brodsky L, Moore L, Stanievich JF. A comparison of tonsillar size and oropharyngeal dimensions in childrenwith obstructive adenotonsillar hypertrophy. Int J Pediatr Otorhinolaryngol 1987;13:149-56. 10.1016/0165-5876(87)90091-7
21. Neyzi O, Furman A, Bundak R, Gunoz H, Darendeliler F, et al. Growth references for Turkish children aged 6 to 18 years. Acta Paediatr 2006;95:1635-41. http://gateway.webofknowledge.com/gateway/Gateway.cgiGWVersion=2&SrcApp=PARTNER-APP&SrcAuth=LinksAMR&KeyUT=000243993800043&DestLinkType=FullRecord&DestApp=ALL-WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3
22. Guilleminault C, Stoohs R. Chronic snoring and obstructive sleep apnea syndrome in children. Lung 1990;168 (Suppl):912-9.
23. Sen TA, Ayçiçek A. Do children with adenotonsillar hypertrophy have lower IGF-1 and ghrelin levels than the normal children Int J Pediatr Otorhinolaryngol 2010;74:665-8.
24. Ersoy B, Yuceturk AV, Taneli F, Urk V, Uyanik BS. Changes in growth pattern, body composition and biochemical markers of growth after adenotonsillectomy in prepubertal children. Int J Pediatr Otorhinolaryngol 2005;69:1175-81.
25. Aydogan M, Toprak D, Hatun S, Yuksel A, Gokalp AS. The effect of recurrent tonsillitis and adenotonsillectomy on growth in childhood. Int J Pediatr Otorhinolaryngol 2007;71:1737-42. 10.1016/j.ijporl.2007.07.01217850885http://gateway.webofknowledge.com/gateway/Gateway.cgiGWVersion=2&SrcApp=PARTNER-APP&SrcAuth=LinksAMR&KeyUT=000250900400012&DestLinkType=FullRecord&DestApp=ALL-WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3
26. Kang JM, Auo HJ, Yoo YH, Cho JH, Kim BG. Changes in serum levels of IGF-1 and in growth following adenotonsillectomy in children. Int J Pediatr Otorhinolaryngol 2008;72:1065-9. http://gateway.webofknowledge.com/gateway/Gateway.cgiGWVersion=2&SrcApp=PARTNER-APP&SrcAuth=LinksAMR&KeyUT=000257482500020&DestLinkType=FullRecord&DestApp=ALL-WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f310.1016/j.ijporl.2008.03.015
27. Gumussoy M, Atmaca S, Bilgici B, Unal R. Changes in IGF-I, IGFBP-3 and ghrelin levels after adenotonsillectomy in children with sleep disordered breathing. Int J Pediatr Otorhinolaryngol 2009;73:1653-6. 19765833
28. Nieminen P, Löppönen T, Tolonen U, Lannig P, Klip M, et al. Growth and biochemical markers of growth in children with snoring and obstructive sleep apnea. Pediatrics 2002;109:e55.
29. Gnanapavan S, Kola B, Bustin SA, Morris DG, McGee P, et al. The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans. J Clin Endocrinol Metab 2002;87:2988-91.
30. Koc S, Ozturk K, Buyukbas S, Kocabas V, Ozer B, et al. Ghrelin levels in children with adenoid or chronic tonsil hypertrophies before and after surgery. Int J Pediatr Otorhinolaryngol 2009;73:685-7. http://gateway.webofknowledge.com/gateway/Gateway.cgiGWVersion=2&SrcApp=PARTNER-APP&SrcAuth=LinksAMR&KeyUT=000265767800012&DestLinkType=FullRecord&DestApp=ALL-WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3
31. Andiran N, Celik N, Ark N, Koca C, Kurtaran H, et al. Changes in growth pattern, leptin ghrelin and neuropeptide Y levels after adenotonsillectomy in prepubertal children. J Pediatr Endocrinol Metab 2013;26:683-7. 23612639
32. Ceddia RB, Koistinen HA, Zierath JR, Sweeney G. Analysis of paradoxical observations on the association between leptin and insulin resistance. FASEB J 2002;16:1163-76. 1215398410.1096/fj.02-0158rev
33. Kilic M, Taskin E, Ustundag B, Aygun AD. The evaluation of serum leptin level and other hormonal parameters in children with severe malnutrition. Clin Biochem 2004;37:382-7.
34. Cummings DE, Overduin J. Gastrointestinal regulation of food intake. J Clin Invest 2007;117:13-23.
35. Tschop M, Weyer C, Tataranni PA, Devanarayan V, Ravussin E, et al. Circulating ghrelin levels are decreased in human obesity. Diabetes 2001;50:707-9.
36. Yoshihara F, Kojima M, Hosoda H, Nakazato M, Kangawa K. Ghrelin: a novel peptide for growth hormone release and feeding regulation, Curr Opin Clin Nutr Metab Care 2002;5:391-5. 10.1097/00075197-200207000-0000712107374
37. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K, Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999;402:656-60.