Why are there no good treatments for diabetic neuropathy?

The Lancet Diabetes and Endocrinology

Volumn 2, Issue 8, 2014, Pages 607-609

  Malik, Rayaz A ^a,b  

^a MANCHESTER UNIVERSITY NHS FOUNDATION TRUST   (United Kingdom)

^b WEILL CORNELL MEDICAL COLLEGE   (Qatar)

Author keywords

[No Author keywords available]

Indexed keywords

DULOXETINE; PREGABALIN; TAPENTADOL; BIOLOGICAL MARKER;

AMPUTATION; CLINICAL TRIAL (TOPIC); CONFOCAL MICROSCOPY; DIABETES MELLITUS; DIABETIC NEUROPATHY; FOOT ULCER; GLYCEMIC CONTROL; HUMAN; MORTALITY; NERVE FIBER; NEUROPATHIC PAIN; NOCICEPTION; NOTE; PHASE 3 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; COST OF ILLNESS; DIABETIC NEUROPATHIES; DRUG EFFECTS; HEALTH; HEALTH CARE PLANNING; MEDICAL RESEARCH; METHODOLOGY; PAIN; PAIN MEASUREMENT; PERIPHERAL NERVOUS SYSTEM DISEASES; REPRODUCIBILITY;

BIOMARKERS; BIOMEDICAL RESEARCH; COST OF ILLNESS; DIABETIC NEUROPATHIES; GLOBAL HEALTH; HEALTH PRIORITIES; HUMANS; PAIN; PAIN MEASUREMENT; PERIPHERAL NERVOUS SYSTEM DISEASES; REPRODUCIBILITY OF RESULTS; RESEARCH DESIGN;

EID: 84906937177     PISSN: 22138587     EISSN: 22138595     Source Type: Journal    
DOI: 10.1016/S2213-8587(14)70067-1     Document Type: Note

References (10)

1. Tesfaye S, Boulton AJ, Dickenson AH Mechanisms and management of diabetic painful distal symmetrical polyneuropathy. Diabetes Care 2013, 36:2456-2465.
2. Holman N, Young RJ, Jeffcoate WJ Variation in the recorded incidence of amputation of the lower limb in England. Diabetologia 2012, 55:1919-1925.
3. Hsu WC, Chiu SY, Yen AM, et al. Somatic neuropathy is an independent predictor of all- and diabetes-related mortality in type 2 diabetic patients: a population-based 5-year follow-up study (KCIS No. 29). Eur J Neurol 2012, 19:1192-1198.
4. Callaghan BC, Little AA, Feldman EL, Hughes RA Enhanced glucose control for preventing and treating diabetic neuropathy. Cochrane Database Syst Rev 2012, 6. CD007543.
5. Dyck PJ, Herrmann DN, Staff NP Assessing decreased sensation and increased sensory phenomena in diabetic polyneuropathies. Diabetes 2013, 62:3677-3686.
6. Dyck PJ, Overland CJ, Low PA, et al. Signs and symptoms versus nerve conduction studies to diagnose diabetic sensorimotor polyneuropathy: Cl vs. NPhys trial. Muscle Nerve 2010, 42:157-164.
7. Dyck PJ, Albers JW, Wolfe J, et al. A trial of proficiency of nerve conduction: greater standardization still needed. Muscle Nerve 2013, 48:369-374.
8. Hoeijmakers JG, Faber CG, Lauria G, Merkies IS, Waxman SG Small-fibre neuropathies-advances in diagnosis, pathophysiology and management. Nat Rev Neurol 2012, 8:369-379.
9. Quattrini C, Tavakoli M, Jeziorsk M, et al. Surrogate markers of small fiber damage in human diabetic neuropathy. Diabetes 2007, 56:2148-2154.
10. Tavakoli M, Mitu-Pretorian M, Petropoulos IN, et al. Corneal confocal microscopy detects early nerve regeneration in diabetic neuropathy after simultaneous pancreas and kidney transplantation. Diabetes 2013, 62:254-260.