Association between circulating endogenous androgens and insulin sensitivity changes with exercise training in midlife women

Menopause

Volumn 21, Issue 9, 2014, Pages 967-974

  Krishnan, Sridevi ^a   Gustafson, Mary B ^b   Campbell, Caitlin ^a,b   Gaikwad, Nilesh W ^a   Keim, Nancy L ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b U S DEPARTMENT OF AGRICULTURE   (United States)

Author keywords

Dehydroepiandrosterone sulfate; Insulin sensitivity; Physical activity

Indexed keywords

ANDROGEN; ESTRADIOL; GLUCOSE; INSULIN; LIPID; PRASTERONE; PRASTERONE SULFATE; PROGESTERONE; SEX HORMONE; TESTOSTERONE; CHOLESTEROL; ESTROGEN; GLUCOSE BLOOD LEVEL;

ADULT; AEROBIC CAPACITY; ARTICLE; BODY COMPOSITION; BODY WEIGHT; CLIMACTERIUM; CLINICAL ARTICLE; ESTRADIOL BLOOD LEVEL; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID BLOOD LEVEL; MIDDLE AGED; PROGESTERONE BLOOD LEVEL; QUANTITATIVE INSULIN SENSITIVITY CHECK INDEX; RANDOMIZED CONTROLLED TRIAL; RESISTANCE TRAINING; SEDENTARY LIFESTYLE; TESTOSTERONE BLOOD LEVEL; BLOOD; CARDIOVASCULAR DISEASES; CONTROLLED STUDY; KINESIOTHERAPY; MENOPAUSE;

ADULT; ANDROGENS; BLOOD GLUCOSE; BODY COMPOSITION; CARDIOVASCULAR DISEASES; CHOLESTEROL; DEHYDROEPIANDROSTERONE; ESTROGENS; EXERCISE THERAPY; FEMALE; HUMANS; INSULIN RESISTANCE; MENOPAUSE; MIDDLE AGED; PROGESTERONE; TESTOSTERONE;

EID: 84906936518     PISSN: 10723714     EISSN: 15300374     Source Type: Journal    
DOI: 10.1097/GME.0000000000000198     Document Type: Article

References (38)

1. Creatsa M, Armeni E, Stamatelopoulos K, et al. Circulating androgen levels are associated with subclinical atherosclerosis and arterial stiffness in healthy recently menopausal women. Metabolism 2012;61:193-201.
2. Tok C, Ertunc D, Evruke C, Dilek S. The androgenic profile of women with non Yinsulin-dependent diabetes mellitus. J Reprod Med 2004; 49:746-752.
3. Yasui T, Matsui S, Tani A, Kunimi K, Yamamoto S, Irahara M. Androgen in postmenopausal women. J Med Invest 2012;59:12-27.
4. Davis SR, Panjari M, Stanczyk FZ. Clinical review: DHEA replacement for postmenopausal women. J Clin Endocrinol Metab 2011;96:1642-1653.
5. Barrett-Connor E, Khaw KT, Yen SS. A prospective study of dehydroepiandrosterone sulfate, mortality, and cardiovascular disease. N Engl J Med 1986;315:1519-1524.
6. Shufelt C, Bretsky P, Almeida CM, et al. DHEA-S levels and cardiovascular disease mortality in postmenopausal women: results from the National Institutes of Health-National Heart, Lung, and Blood Institute (NHLBI)Ysponsored Women's Ischemia Syndrome Evaluation (WISE). J Clin Endocrinol Metab 2010;95:4985-4992.
7. Sternfeld B, Wang H, Quesenberry CP Jr, et al. Physical activity and changes in weight and waist circumference in midlife women: findings from the Study of Women's Health Across the Nation. Am J Epidemiol 2004;160:912-922.
8. Sammel MD, Grisso JA, Freeman EW, et al. Weight gain among women in the late reproductive years. Fam Pract 2003;20:401-409.
9. Labrie F, Bélanger A, Cusan L, Gomez JL, Candas B. Marked decline in serum concentrations of adrenal C19 sex steroid precursors and conjugated androgen metabolites during aging. J Clin Endocrinol Metab 1997; 82:2396-2402.
10. Lasley BL, Santoro N, Randolf JF, et al. The relationship of circulating dehydroepiandrosterone, testosterone, and estradiol to stages of the menopausal transition and ethnicity. J Clin Endocrinol Metab 2002;87:3760-3767.
11. Ciolac EG, Greve JM. Exercise-induced improvements in cardiorespiratory fitness and heart rate response to exercise are impaired in overweight/obese postmenopausal women. Clinics 2011;66:583-589.
12. Kerksick CM, Wismann-Bunn J, Fogt D, et al. Changes in weight loss, body composition and cardiovascular disease risk after altering macronutrient distributions during a regular exercise program in obese women. Nutr J 2010;9:59.
13. Friedenreich CM, Woolcott C, McTiernan A, et al. Alberta Physical Activity and Breast Cancer Prevention Trial: sex hormone changes in a year-long exercise intervention among postmenopausal women. J Clin Oncol 2010;28:1458-1466.
14. van Gils CH, Peeters PH, Schoenmakers MC, et al. Physical activity and endogenous sex hormone levels in postmenopausal women: a crosssectional study in the Prospect-EPIC Cohort. Cancer Epidemiol Biomarkers Prev 2009;18:377-383.
15. Vingren JL, Kraemer WJ, Ratamess NA, Anderson JM, Volek JS, Maresh CM. Testosterone physiology in resistance exercise and training: the up-stream regulatory elements. Sports Med 2010;40:1037-1053.
16. Enea C, Boisseau N, Fargeas-Gluck MA, Diaz V, Dugue B. Circulating androgens in women: exercise-induced changes. Sports Med 2011;41:1-15.
17. Bastian LA, Smith CM, Nanda K. Is this woman perimenopausal? JAMA 2003;289:895-902.
18. Practice Committee of the American Society for Reproductive Medicine. The menopausal transition. Fertil Steril 2008;90(suppl 3):S61-S65.
19. McAuley KA, Williams SM, Mann JI, et al. Diagnosing insulin resistance in the general population. Diabetes Care 2001;24:460-464.
20. Wallace TM, Levy JC, Matthews DR. Use and abuse of HOMA modeling. Diabetes Care 2004;27:1487-1495.
21. Gaikwad NW, Yang L, Muti P, et al. The molecular etiology of breast cancer: evidence from biomarkers of risk. Int J Cancer 2008;122:1949-1957.
22. Aizawa K, Akimoto T, Inoue H, et al. Resting serum dehydroepiandrosterone sulfate level increases after 8-week resistance training among young females. Eur J Appl Physiol 2003;90:575-580.
23. R Development Core Team. R: A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing, 2011.
24. Fox J. The R Commander: a basic statistics graphical user interface to R. J Stat Softw 2005;14:1-42.
25. Rosner B. Fundamentals of Biostatistics. Boston, MA: Brooks Cole/Cengage Learning, 2006.
26. Enea C, Boisseau N, Ottavy M, et al. Effects of menstrual cycle, oral contraception, and training on exercise-induced changes in circulating DHEA-sulphate and testosterone in young women. Eur J Appl Physiol 2009;106:365-373.
27. Schmitz KH, Lin H, Sammel MD, et al. Association of physical activity with reproductive hormones: the Penn Ovarian Aging Study. Cancer Epidemiol Biomarkers Prev 2007;16:2042-2047.
28. McTiernan A, Tworoger SS, Rajan KB, et al. Effect of exercise on serum androgens in postmenopausal women: a 12-month randomized clinical trial. Cancer Epidemiol Biomarkers Prev 2004;13:1099-1105.
29. Crawford S, Santoro N, Laughlin GA, et al. Circulating dehydroepiandrosterone sulfate concentrations during the menopausal transition. J Clin Endocrinol Metab 2009;94:2945-2951.
30. Porsová-Dutoit I, Sulcová J, Stárka L. Do DHEA/DHEAS play a protective role in coronary heart disease? Physiol Res 2000;49(suppl 1):S43-S56.
31. Kumar A, Woods KS, Bartolucci AA, Azziz R. Prevalence of adrenal androgen excess in patients with the polycystic ovary syndrome (PCOS). Clin Endocrinol (Oxf) 2005;62:644-649.
32. Saruc M, Yuceyar H, Ayhan S, Turkel N, Tuzcuoglu I, Can M. The association of dehydroepiandrosterone, obesity, waist-hip ratio and insulin resistance with fatty liver in postmenopausal women-a hyperinsulinemic euglycemic insulin clamp study. Hepatogastroenterology 2003;50:771-774.
33. McCarty MF. A paradox resolved: the postprandial model of insulin resistance explains why gynoid adiposity appears to be protective. Med Hypotheses 2003;61:173-176.
34. Nyholm B, Mengel A, Nielsen S, et al. Insulin resistance in relatives of NIDDM patients: the role of physical fitness and muscle metabolism. Diabetologia 1996;39:813-822.
35. Hunter GR, Chandler-Laney PC, Brock DW, Lara-Castro C, Fernandez JR, Gower BA. Fat distribution, aerobic fitness, blood lipids, and insulin sensitivity in African-American and European-American women. Obesity 2010;18:274-281.
36. Izzicupo P, D'Amico MA, Bascelli A, et al. Walking training affects dehydroepiandrosterone sulfate and inflammation independent of changes in spontaneous physical activity. Menopause 2013;20:455-463.
37. Straub RH, Scholmerich J, Zietz B. Replacement therapy with DHEA plus corticosteroids in patients with chronic inflammatory diseases-substitutes of adrenal and sex hormones. Z Rheumatol 2000;59: 108-118.
38. Ploeger HE, Takken T, de Greef MHG, Timmons BW. The effects of acute and chronic exercise on inflammatory markers in children and adults with a chronic inflammatory disease: a systematic review. Exerc Immunol Rev 2009;15:6-41.