Decreased exposure of simvastatin and simvastatin acid in a rat model of type 2 diabetes

Acta Pharmacologica Sinica

Volumn 35, Issue 9, 2014, Pages 1215-1225

  Xu, Dan ^a,b   Li, Feng ^a   Zhang, Mian ^a   Zhang, Ji ^a   Liu, Can ^a   Hu, Meng Yue ^a   Zhong, Ze Yu ^a   Jia, Ling Ling ^a   Wang, Da Wei ^b   Wu, Jie ^b   Liu, Li ^a   Liu, Xiao Dong ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b Jiangsu Provincial Institute of Traditional Chinese Medicine ^*  (China)

Author keywords

[No Author keywords available]

Indexed keywords

BREAST CANCER RESISTANCE PROTEIN; CYTOCHROME P450 3A; MESSENGER RNA; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 2; SIMVASTATIN; SOLUTE CARRIER ORGANIC ANION TRANSPORTER 1B1; STREPTOZOCIN; ABC TRANSPORTER; ABCC2 PROTEIN, RAT; ABCG2 PROTEIN, RAT; ORGANIC ANION TRANSPORTER; SIMVASTATIN ACID; SLCO1A4 PROTEIN, RAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EXPOSURE; DRUG METABOLISM; DRUG UPTAKE; LIPID DIET; LIVER CELL; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; SINGLE DRUG DOSE; ANALOGS AND DERIVATIVES; ANIMAL; BLOOD; EXPERIMENTAL DIABETES MELLITUS; LIVER; LIVER MICROSOME; MALE; METABOLISM; SPRAGUE DAWLEY RAT;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; CYTOCHROME P-450 CYP3A; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; HEPATOCYTES; LIVER; MALE; MICROSOMES, LIVER; ORGANIC ANION TRANSPORTERS; RATS; RATS, SPRAGUE-DAWLEY; SIMVASTATIN;

EID: 84906916664     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2014.39     Document Type: Article

References (0)