-
1
-
-
33947596504
-
Why is cancer drug discovery so difficult?
-
Kamb, A., Wee, S. & Lengauer, C. Why is cancer drug discovery so difficult? Nat. Rev. Drug Discov. 6, 115-120 (2007).
-
(2007)
Nat. Rev. Drug Discov.
, vol.6
, pp. 115-120
-
-
Kamb, A.1
Wee, S.2
Lengauer, C.3
-
2
-
-
84876993950
-
Normalizing tumor microenvironment to treat cancer: Bench to bedside to biomarkers
-
Jain, R.K. Normalizing tumor microenvironment to treat cancer: bench to bedside to biomarkers. J. Clin. Oncol. 31, 2205-2218 (2013).
-
(2013)
J. Clin. Oncol.
, vol.31
, pp. 2205-2218
-
-
Jain, R.K.1
-
3
-
-
84874760414
-
Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma
-
Snuderl, M. et al. Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma. Cell 152, 1065-1076 (2013).
-
(2013)
Cell
, vol.152
, pp. 1065-1076
-
-
Snuderl, M.1
-
4
-
-
79954606458
-
CXCL12 (SDF1alpha)-CXCR4/CXCR7 pathway inhibition: An emerging sensitizer for anticancer therapies?
-
Duda, D.G., Kozin, S.V., Kirkpatrick, N.D., Xu, L., Fukumura, D. & Jain, R.K. CXCL12 (SDF1alpha)-CXCR4/CXCR7 pathway inhibition: an emerging sensitizer for anticancer therapies? Clin. Cancer Res. 17, 2074-2080 (2011).
-
(2011)
Clin. Cancer Res.
, vol.17
, pp. 2074-2080
-
-
Duda, D.G.1
Kozin, S.V.2
Kirkpatrick, N.D.3
Xu, L.4
Fukumura, D.5
Jain, R.K.6
-
5
-
-
36749019138
-
Trends in the use and role of biomarkers in phase i oncology trials
-
Goulart, B.H., Clark, J.W., Pien, H.H., Roberts, T.G., Finkelstein, S.N. & Chabner, B.A. Trends in the use and role of biomarkers in phase I oncology trials. Clin. Cancer Res. 13, 6719-6726 (2007).
-
(2007)
Clin. Cancer Res.
, vol.13
, pp. 6719-6726
-
-
Goulart, B.H.1
Clark, J.W.2
Pien, H.H.3
Roberts, T.G.4
Finkelstein, S.N.5
Chabner, B.A.6
-
6
-
-
0043269344
-
Auditing the pharmacological accounts for Hsp90 molecular chaperone inhibitors: Unfolding the relationship between pharmacokinetics and pharmacodynamics
-
Workman, P. Auditing the pharmacological accounts for Hsp90 molecular chaperone inhibitors: unfolding the relationship between pharmacokinetics and pharmacodynamics. Mol. Cancer Ther. 2, 131-138 (2003).
-
(2003)
Mol. Cancer Ther.
, vol.2
, pp. 131-138
-
-
Workman, P.1
-
7
-
-
59449085305
-
Phase i study of the poly(ADP-ribose) polymerase inhibitor, AG014699, in combination with temozolomide in patients with advanced solid tumors
-
Plummer, R. et al. Phase I study of the poly(ADP-ribose) polymerase inhibitor, AG014699, in combination with temozolomide in patients with advanced solid tumors. Clin. Cancer Res. 14, 7917-7923 (2008).
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 7917-7923
-
-
Plummer, R.1
-
8
-
-
27744573159
-
Novel Phase i dose de-escalation design trial to determine the biological modulatory dose of the antiangiogenic agent SU5416
-
Dowlati, A. et al. Novel Phase I dose de-escalation design trial to determine the biological modulatory dose of the antiangiogenic agent SU5416. Clin. Cancer Res. 11, 7938-7944 (2005).
-
(2005)
Clin. Cancer Res.
, vol.11
, pp. 7938-7944
-
-
Dowlati, A.1
-
9
-
-
39749131036
-
Preclinical pharmacokinetic/ pharmacodynamic models of gefitinib and the design of equivalent dosing regimens in EGFR wild-type and mutant tumor models
-
Wang, S., Guo, P., Wang, X., Zhou, Q. & Gallo, J.M. Preclinical pharmacokinetic/ pharmacodynamic models of gefitinib and the design of equivalent dosing regimens in EGFR wild-type and mutant tumor models. Mol. Cancer Ther. 7, 407-417 (2008).
-
(2008)
Mol. Cancer Ther.
, vol.7
, pp. 407-417
-
-
Wang, S.1
Guo, P.2
Wang, X.3
Zhou, Q.4
Gallo, J.M.5
-
10
-
-
84877018103
-
Translational pharmacokinetic-pharmacodynamic modeling from nonclinical to clinical development: A case study of anticancer drug, crizotinib
-
Yamazaki, S. Translational pharmacokinetic-pharmacodynamic modeling from nonclinical to clinical development: a case study of anticancer drug, crizotinib. AAPS J. 15, 354-366 (2013).
-
(2013)
AAPS J.
, vol.15
, pp. 354-366
-
-
Yamazaki, S.1
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