STUDY ON OPTIMISATION OF EXTRACTION PROCESS OF TANSHINONE IIA AND ITS MECHANISM OF INDUCTION OF GASTRIC CANCER SGC7901 CELL APOPTOSIS

African Journal of Traditional, Complementary and Alternative Medicines

Volumn 10, Issue 6, 2013, Pages 456-458

  Hou, Jianhong ^a   He, Jiantai ^a   Jin, Xin ^a   Hu, Tian ^a   Zhang, Yangde ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

gastric cancer SGC7901 cells; MTT assay; Tanshinone A

Indexed keywords

ABIETANE DERIVATIVE; ANTINEOPLASTIC AGENT; PLANT EXTRACT; TANSHINONE; TANSHINONE IIA;

ADENOCARCINOMA; APOPTOSIS; ARTICLE; CELL PROLIFERATION; DRUG EFFECT; DRUG SCREENING; GASTRIC CANCER SGC7901 CELLS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MEDICINAL CHEMISTRY; METHODOLOGY; MTT ASSAY; SALVIA MILTIORRHIZA; STOMACH TUMOR; TRANSMISSION ELECTRON MICROSCOPY; TUMOR CELL LINE;

GASTRIC CANCER SGC7901 CELLS; MTT ASSAY; TANSHINONE IIA;

ADENOCARCINOMA; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DITERPENES, ABIETANE; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MICROSCOPY, ELECTRON, TRANSMISSION; PLANT EXTRACTS; SALVIA MILTIORRHIZA; STOMACH NEOPLASMS;

EID: 84906843325     PISSN: None     EISSN: 25050044     Source Type: Journal    
DOI: 10.4314/ajtcam.v10i6.10     Document Type: Article

References (12)

1. Cai LP, Xi ZG, YH. (2008) Progress in pharmacological effects and clinical research of tanshinone. Journal of Guangdong Pharmaceutical College, 24(3): 321-324
2. Chen J..and Lin G.J. (2003) Research Advance in Anti-tumor Function of Salvia miltiorrhiza Bge. Fudan University Journal of Medical Sciences, 30(6): 626-628
3. Deng Y. and, Wu X. (2000) Peg3/Pwl promotes p53-mediated apoptosis by inducing bax translocation from cytosol to mitochondria. Proc Natl Acad Sci USA, 97: 12050-12052
4. He J.T, Zhou Q.H., Yuan S.L., Wang Y.P., Chen X.H., and Qin J.J. (2002).The growth-inhibiting effect and its molecular mechanism of Tanshinone on human lung cancer cell line in vitro. Chinese Journal of Lung Cancer, 5(2): 123-125
5. Lee J.S., Han S.Y., Kim M.S., Yu C.M., Kim M.H., Kim S.H., Min Y.K., and Kim BT. (2006) Synthesis of novel chemical probes for the study of tanshinone binding proteins. Bioorg Med Chem Lett, 16: 4733-4737
6. Liu J.J., Lin D.J., Liu P.Q., Huang M., Li X.D., and Huang R.W. (2006) Induction of apoptosis and inhibition of cell adhesive and invasive effects by tanshinone IIA in acute promyelocytic leukemia cells in vitro. Biomed Sci, 13: 813-823
7. Liu M.M., Zhao L., Zhang M., and Liu L.L. (2009) Optimization of Extraction Method of Tanshinone ⅡA by Orthogonal Experiment. Chinese Journal of Ethnomedicine and Ethnopharmacy, 8: 16-17
8. Sun X.G., and Jia Y.H. (2002) The Effects of Tanshinone ⅡA on Intracellular Free Calcium, Membrane Potential and Mitochondrial Membrane Potential of Normal and Hypoxia Myocytes in Rats. Chinese Journal of Information on Traditional Chinese Medicine, 9(9): 21-23
9. Wang D., Tian Y.P., Jiang Y.Y., Ren B.H., Yang N.J., and Fang Q. (2007) Effects of tanshinone ⅡA on proliferation and apoptosis of human cervical carcinoma HeLa cells in vitro. China Journal of Modern Medicine, 17(6): 676-678
10. Yang Y.M..and Liu T. (2006) Complete remission of acute promyelocytic leukemia resisting all-trans retinoic acid of one case treated by tanshinone II A. Sichuan Da Xue Xue Bao Yi Xue Ban, 37: 965-967.
11. Zhao G., He S.X., Fu H., Xu J.L., Wang Y.L., and Ren M.D. (2003) Effect of Tanshinone IIA on SMMC-7721 gene expression of TGF-β1. Chinese Journal of Gastroenterology and Herpetology, 25: 296-298
12. Zhang S,Z., Ye Z.G., Xia Q., Zhang W., and Bruce I. (2005) Inhibition of Mitochondrial Permeability Transition Pore: A Possible Mechanism for Cardio protection Conferred by Pretreatment with Tanshinone IIA. Conf Proc IEEE Eng Med Biol Soc, 3: 2276-2279.