NK cells mediate the cumulative analgesic effect of electroacupuncture in a rat model of neuropathic pain

BMC Complementary and Alternative Medicine

Volumn 14, Issue 1, 2014, Pages

  Gao, Yong Hui ^a   Wang, Jun Ying ^a   Qiao, Li Na ^a   Chen, Shu Ping ^a   Tan, Lian Hong ^a   Xu, Qiu Ling ^b   Liu, Jun Ling ^a  

^a INSTITUTE OF CHINESE MATERIA MEDICA   (China)

^b HAINAN MEDICAL UNIVERSITY   (China)

Author keywords

Acquired immunity; Acupuncture analgesia; Chronic constriction injury; Cumulative effect; Innate immunity; NK cells

Indexed keywords

ANTIBODY; BETA ENDORPHIN; GAMMA INTERFERON; GANGLIOTETRAOSYLCERAMIDE; GANGLIOTETRAOSYLCERAMIDE ANTIBODY; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 15; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ADAPTIVE IMMUNITY; ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4 CD8 RATIO; CELL ACTIVITY; CHRONIC CONSTRICTION INJURY; COLORIMETRY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; DOWN REGULATION; ELECTROACUPUNCTURE; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE ACTIVATED CELL SORTING; FOOT PAD; IMMUNE RESPONSE; INNATE IMMUNITY; LYMPHOCYTE ACTIVATION; LYMPHOCYTE DEPLETION; MALE; METHYL THIAZOLYL TETRAZOLIUM COLORIMETRIC METHOD; NATURAL KILLER CELL; NERVE LIGATION; NEUROPATHIC PAIN; NONHUMAN; PAIN THRESHOLD; PLASMA CELL; PROTEIN BLOOD LEVEL; RAT; SCIATIC NERVE; SPLEEN LYMPHOCYTE; UPREGULATION; ACUPUNCTURE ANALGESIA; ANIMAL; BLOOD; HUMAN; IMMUNOLOGY; NEURALGIA; WISTAR RAT;

ACUPUNCTURE ANALGESIA; ANIMALS; BETA-ENDORPHIN; ELECTROACUPUNCTURE; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-1BETA; INTERLEUKIN-2; KILLER CELLS, NATURAL; MALE; NEURALGIA; RATS; RATS, WISTAR;

EID: 84906838922     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/1472-6882-14-316     Document Type: Article

References (40)

1. Calvo M, Dawes JM, Bennett DL. The role of the immune system in the generation of neuropathic pain. Lancet Neurol 2012, 11(7):629-642.
2. Ren K, Dubner R. Interactions between the immune and nervous systems in pain. Nat Med 2010, 16(11):1267-1276.
3. Jones SA. Directing transition from innate to acquired immunity: defining a role for IL-6. J Immunol 2005, 175(6):3463-3468.
4. Guo LH, Schluesener HJ. The innate immunity of the central nervous system in chronic pain: the role of Toll-like receptors. Cell Mol Life Sci 2007, 64(9):1128-1136.
5. Vincent A, Bien CG, Irani SR, Waters P. Autoantibodies associated with diseases of the CNS: new developments and future challenges. Lancet Neurol 2011, 10(8):759-772.
6. Kohr D, Singh P, Tschernatsch M, Kaps M, Pouokam E, Diener M, Kummer W, Birklein F, Vincent A, Goebel A, Wallukat G, Blaes F. Autoimmunity against the beta2 adrenergic receptor and muscarinic-2 receptor in complex regional pain syndrome. Pain 2011, 152(12):2690-2700.
7. Austin PJ, Moalem-Taylor G. The neuro-immune balance in neuropathic pain: involvement of inflammatory immune cells, immune-like glial cells and cytokines. J Neuroimmunol 2010, 229(1-2):26-50.
8. Leibing E, Leonhardt U, Koster G, Goerlitz A, Rosenfeldt JA, Hilgers R, Ramadori G. Acupuncture treatment of chronic low-back pain - a randomized, blinded, placebo-controlled trial with 9-month follow-up. Pain 2002, 96(1-2):189-196.
9. Carlsson CP, Sjolund BH. Acupuncture for chronic low back pain: a randomized placebo-controlled study with long-term follow-up. Clin J Pain 2001, 17(4):296-305.
10. Shen YF, Goddard G. The short-term effects of acupuncture on myofascial pain patients after clenching. Pain Pract 2007, 7(3):256-264.
11. Kim HN, Park JH, Kim SK, Sun B, Koo S, Choi SM, Bae H, Min BI. Electroacupuncture potentiates the antiallodynic effect of intrathecal neostigmine in a rat model of neuropathic pain. J Physiol Sci 2008, 58(5):357-360.
12. Yim YK, Lee H, Hong KE, Kim YI, Lee BR, Son CG, Kim JE. Electro-acupuncture at acupoint ST36 reduces inflammation and regulates immune activity in collagen-induced arthritic mice. Evid Based Complement Alternat Med 2007, 4(1):51-57.
13. Quispe-Cabanillas JG, Damasceno A, von Glehn F, Brandao CO, Damasceno BP, Silveira WD, Santos LM. Impact of electroacupuncture on quality of life for patients with relapsing-remitting multiple sclerosis under treatment with immunomodulators: a randomized study. BMC Complement Altern Med 2012, 12:209.
14. Lin JG, Chen WL. Acupuncture analgesia: a review of its mechanisms of actions. Am J Chin Med 2008, 36(4):635-645.
15. Cabyoglu MT, Ergene N, Tan U. The mechanism of acupuncture and clinical applications. Int J Neurosci 2006, 116(2):115-125.
16. Wang J, Zhao H, Mao-Ying QL, Cao XD, Wang YQ, Wu GC. Electroacupuncture downregulates TLR2/4 and pro-inflammatory cytokine expression after surgical trauma stress without adrenal glands involvement. Brain Res Bull 2009, 80(1-2):89-94.
17. Kim CK, Choi GS, Oh SD, Han JB, Kim SK, Ahn HJ, Bae H, Min BI. Electroacupuncture up-regulates natural killer cell activity identification of genes altering their expressions in electroacupuncture induced up-regulation of natural killer cell activity. J Neuroimmunol 2005, 168(1-2):144-153.
18. Gao Y, Chen S, Xu Q, Yu K, Wang J, Qiao L, Meng F, Liu J. Proteomic analysis of differential proteins related to anti-nociceptive effect of electroacupuncture in the hypothalamus following neuropathic pain in rats. Neurochem Res 2013, 38(7):1467-1478.
19. Liu JL, Chen SP, Gao YH, Meng FY, Wang SB, Wang JY. Effects of repeated electroacupuncture on beta-endorphin and adrencorticotropic hormone levels in the hypothalamus and pituitary in rats with chronic pain and ovariectomy. Chin J Integr Med 2010, 16(4):315-323.
20. Gao YH, Chen SP, Wang JY, Qiao LN, Meng FY, Xu QL, Liu JL. Differential proteomics analysis of the analgesic effect of electroacupuncture intervention in the hippocampus following neuropathic pain in rats. BMC Complement Altern Med 2012, 12:241.
21. Wang K, Wu H, Wang G, Li M, Zhang Z, Gu G. The effects of electroacupuncture on TH1/TH2 cytokine mRNA expression and mitogen-activated protein kinase signaling pathways in the splenic T cells of traumatized rats. Anesth Analg 2009, 109(5):1666-1673.
22. Carneiro ER, Xavier RA, De Castro MA, Do Nascimento CM, Silveira VL. Electroacupuncture promotes a decrease in inflammatory response associated with Th1/Th2 cytokines, nitric oxide and leukotriene B4 modulation in experimental asthma. Cytokine 2010, 50(3):335-340.
23. Bennett GJ, Xie YK. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain 1988, 33(1):87-107.
24. Dou J, Chen JS, Wang J, Chen GB, Zhao FS, Tang Q, Fang XS, Chu LL, Pan M. Novel constructs of tuberculosis gene vaccine and its immune effect on mice. Cell Mol Immunol 2005, 2(1):57-62.
25. Chen CP, Boyadjieva NI, Advis JP, Sarkar DK. Ethanol suppression of the hypothalamic proopiomelanocortin level and the splenic NK cell cytolytic activity is associated with a reduction in the expression of proinflammatory cytokines but not anti-inflammatory cytokines in neuroendocrine and immune cells. Alcohol Clin Exp Res 2006, 30(11):1925-1932.
26. Kavoussi B, Ross BE. The neuroimmune basis of anti-inflammatory acupuncture. Integr Cancer Ther 2007, 6(3):251-257.
27. Panerai AE, Sacerdote P. Beta-endorphin in the immune system: a role at last?. Immunol Today 1997, 18(7):317-319.
28. Yu Y, Kasahara T, Sato T, Asano K, Yu G, Fang J, Guo S, Sahara M, Hisamitsu T. Role of endogenous interferon-gamma on the enhancement of splenic NK cell activity by electroacupuncture stimulation in mice. J Neuroimmunol 1998, 90(2):176-186.
29. Yu Y, Kasahara T, Sato T, Guo SY, Liu Y, Asano K, Hisamitsu T. Enhancement of splenic interferon-gamma, interleukin-2, and NK cytotoxicity by S36 acupoint acupuncture in F344 rats. Jpn J Physiol 1997, 47(2):173-178.
30. Herzberg U1, Murtaugh M, Beitz AJ. Chronic pain and immunity: mononeuropathy alters immune responses in rats. Pain 1994, 59(2):219-225.
31. Sunagawa M1, Okada M, Guo SY, Hisamitsu T. Splenic natural killer cell activity is suppressed by ligation of unilateral mental nerve in rats. Masui 2000, 49(3):250-254.
32. Cao L1, DeLeo JA. CNS-infiltrating CD4+ T lymphocytes contribute to murine spinal nerve transection-induced neuropathic pain. Eur J Immunol 2008, 38(2):448-458.
33. Grace PM1, Rolan PE, Hutchinson MR. Peripheral immune contributions to the maintenance of central glial activation underlying neuropathic pain. Brain Behav Immun 2011, 25(7):1322-1332.
34. Luster AD. The role of chemokines in linking innate and adaptive immunity. Curr Opin Immunol 2002, 14(1):129-135.
35. Young HA, Ortaldo J. Cytokines as critical co-stimulatory molecules in modulating the immune response of natural killer cells. Cell Res 2006, 16(1):20-24.
36. Caligiuri MA. Human natural killer cells. Blood 2008, 112(3):461-469.
37. Terrazzano G, Carbone E. NK cells blur the frontier between innate and acquired immunity. Front Immunol 2013, 3:400.
38. Vivier E, Tomasello E, Baratin M, Walzer T, Ugolini S. Functions of natural killer cells. Nat Immunol 2008, 9(5):503-510.
39. Brilot F, Strowig T, Munz C. NK cells interactions with dendritic cells shape innate and adaptive immunity. Front Biosci 2008, 13:6443-6454.
40. Khan IA, MacLean JA, Lee FS, Casciotti L, DeHaan E, Schwartzman JD, Luster AD. IP-10 is critical for effector T cell trafficking and host survival in Toxoplasma gondii infection. Immunity 2000, 12(5):483-494.