Von willebrand factor drives the association between elevated factor VIII and poor outcomes in patients with ischemic stroke

Stroke

Volumn 45, Issue 9, 2014, Pages 2789-2791

  Samai, Alyana ^a,b   Monlezun, Dominique ^a   Shaban, Amir ^a   George, Alexander ^a   Dowell, Lauren ^a   Kruse Jarres, Rebecca ^a   Schluter, Laurie ^a   El Khoury, Ramy ^a   Martin Schild, Sheryl ^a  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TULANE UNIVERSITY   (United States)

Author keywords

blood coagulation factors; factor VIII; stroke; thrombosis; von Willebrand factor

Indexed keywords

BLOOD CLOTTING FACTOR 8; VON WILLEBRAND FACTOR;

ADULT; AGED; BLOOD; CEREBROVASCULAR ACCIDENT; CROSS-SECTIONAL STUDY; FEMALE; HUMAN; ISCHEMIA; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY; PROSPECTIVE STUDY; REGISTER; RISK FACTOR; THROMBOSIS; TREATMENT OUTCOME; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; CROSS-SECTIONAL STUDIES; FACTOR VIII; FEMALE; HUMANS; ISCHEMIA; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; REGISTRIES; RISK FACTORS; STROKE; THROMBOSIS; TREATMENT OUTCOME; VON WILLEBRAND FACTOR;

EID: 84906809582     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.114.006394     Document Type: Article

References (9)

1. Sakariassen KS, Bolhuis PA, Sixma JJ. Human blood platelet adhesion to artery subendothelium is mediated by factor VIII-Von Willebrand factor bound to the subendothelium. Nature. 1979;279:636-638.
2. Tschopp TB, Weiss HJ, Baumgartner HR. Decreased adhesion of platelets to subendothelium in von Willebrand's disease. J Lab Clin Med. 1974;83:296-300.
3. Conlan MG, Folsom AR, Finch A, Davis CE, Sorlie P, Marcucci G, et al. Associations of factor VIII and von Willebrand factor with age, race, sex, and risk factors for atherosclerosis. The Atherosclerosis Risk in Communities (ARIC) Study. Thromb Haemost. 1993;70:380-385.
4. Chang TR, Albright KC, Boehme AK, Dorsey A, Sartor EA, Kruse-Jarres R, et al. Factor VIII in the setting of acute ischemic stroke among patients with suspected hypercoagulable state. Clin Appl Thromb Hemost. 2014;20:124-128.
5. Koster T, Blann AD, Briët E, Vandenbroucke JP, Rosendaal FR. Role of clotting factor VIII in effect of von Willebrand factor on occurrence of deep-vein thrombosis. Lancet. 1995;345:152-155.
6. Shahsavarzadeh T, Javanmard SH, Saadatnia M. Impact of factor VIII and von Willebrand factor plasma levels on cerebral venous and sinus thrombosis: are they independent risk factors? Eur Neurol. 2011;66:243-246.
7. Kyrle PA, Minar E, Hirschl M, Bialonczyk C, Stain M, Schneider B, et al. High plasma levels of factor VIII and the risk of recurrent venous thromboembolism. N Engl J Med. 2000;343:457-462.
8. Folsom AR, Wu KK, Rosamond WD, Sharrett AR, Chambless LE. Prospective study of hemostatic factors and incidence of coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) Study. Circulation. 1997;96:1102-1108.
9. Folsom AR, Rosamond WD, Shahar E, Cooper LS, Aleksic N, Nieto FJ, et al. Prospective study of markers of hemostatic function with risk of ischemic stroke. The Atherosclerosis Risk in Communities (ARIC) Study Investigators. Circulation. 1999;100:736-742.