Increased plasma concentration of ribavirin as a result of renal dysfunction in hepatitis C virus patients treated with telaprevir

Hepatology

Volumn 60, Issue 3, 2014, Pages 1109-1110

  Tempestilli, Massimo ^a   Lionetti, Raffaella ^a   D'Offizi, Gianpiero ^a   Montalbano, Marzia ^a   Giaffreda, Andrea ^a   Fazio, Simone ^a   Pucillo, Leopoldo P ^a  

^a NATIONAL INSTITUTE FOR INFECTIOUS DISEASES L SPALLANZANI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN; PEGINTERFERON; RIBAVIRIN; TELAPREVIR;

ANEMIA; ANTIVIRAL THERAPY; DRUG BLOOD LEVEL; DRUG MONITORING; GLOMERULUS FILTRATION RATE; HEMOGLOBIN BLOOD LEVEL; HEPATITIS C; HEPATITIS C VIRUS GENOTYPE 1; HUMAN; KIDNEY DYSFUNCTION; KIDNEY FUNCTION; LETTER; PRIORITY JOURNAL;

FEMALE; HEPATITIS C, CHRONIC; HUMANS; MALE; OLIGOPEPTIDES; PROLINE; RENAL INSUFFICIENCY;

EID: 84906794883     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.26978     Document Type: Letter

References (4)

1. Jacobson IM, McHutchison JG, Dusheiko G, Di Bisceglie AM, Reddy KR, Bzowej NH, et al. Telaprevir for previously untreated chronic hepatitis C virus infection. N Engl J Med 2011;364:2405-2416.
2. Mauss S, Hueppe D, Alshuth U. Renal impairment is frequent in chronic hepatitis C patients under triple therapy with telaprevir or boceprevir. Hepatology 2014;59:46-48.
3. Levey AS, Stevens LA, Schmid CH, Zhang Y, Castro AF III, Feldman HI, et al. A new equation to estimate glomerular filtration rate. Ann Intern Med 2009;150:604-612.
4. Karino Y, Ozeki I, Hige S, Kimura M, Arakawa T, Nakajima T, et al. Telaprevir impairs renal function and increases blood ribavirin concentration during telaprevir/pegylated interferon/ribavirin therapy for chronic hepatitis C. J Viral Hepat 2013 Aug 25. doi: 10.1111/jvh.12162.