Rhabdoid differentiation is associated with aggressive behavior in renal cell carcinoma: A clinicopathologic analysis of 76 cases with clinical follow-up

American Journal of Surgical Pathology

Volumn 38, Issue 9, 2014, Pages 1260-1265

  Przybycin, Christopher G ^a   McKenney, Jesse K ^a   Reynolds, Jordan P ^a   Campbell, Steven ^a   Zhou, Ming ^a   Karafa, Matthew T ^b   Magi Galluzzi, Cristina ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

clear cell carcinoma; Fuhrman grade; ISUP grade; kidney cancer; rhabdoid differentiation

Indexed keywords

ADULT; AGED; ARTICLE; CANCER GRADING; CANCER STAGING; CELL DIFFERENTIATION; COMPARATIVE STUDY; FEMALE; HUMAN; KIDNEY CARCINOMA; KIDNEY TUMOR; MALE; METASTASIS; MIDDLE AGED; MORTALITY; MULTIVARIATE ANALYSIS; NECROSIS; PATHOLOGY; PROPORTIONAL HAZARDS MODEL; RHABDOID TUMOR; RISK ASSESSMENT; RISK FACTOR; TUMOR INVASION; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, RENAL CELL; CELL DIFFERENTIATION; FEMALE; HUMANS; KIDNEY NEOPLASMS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NECROSIS; NEOPLASM GRADING; NEOPLASM INVASIVENESS; NEOPLASM STAGING; PROPORTIONAL HAZARDS MODELS; RHABDOID TUMOR; RISK ASSESSMENT; RISK FACTORS;

EID: 84906794542     PISSN: 01475185     EISSN: 15320979     Source Type: Journal    
DOI: 10.1097/PAS.0000000000000251     Document Type: Article

References (19)

1. Delahunt B, Cheville JC, Martignoni G, et al. The International Society of Urological Pathology (ISUP) grading system for renal cell carcinoma and other prognostic parameters. Am J Surg Pathol. 2013;37:1490-1504.
2. Gokden N, Nappi O, Swanson PE, et al. Renal cell carcinoma with rhabdoid features. Am J Surg Pathol. 2000;24:1329-1338.
3. Weeks DA, Beckwith JB, Mierau GW, et al. Rhabdoid tumor of kidney. A report of 111 cases from the National Wilms' Tumor Study Pathology Center. Am J Surg Pathol. 1989;13:439-458.
4. Humphrey PA. Renal cell carcinoma with rhabdoid features. J Urol. 2011;186:675-676.
5. Delahunt B, Sika-Paotonu D, Bethwaite PB, et al. Grading of clear cell renal cell carcinoma should be based on nucleolar prominence. Am J Surg Pathol. 2011;35:1134-1139.
6. Kuroiwa K, Kinoshita Y, Shiratsuchi H, et al. Renal cell carcinoma with rhabdoid features: an aggressive neoplasm. Histopathology. 2002;41:538-548.
7. Leroy X, Zini L, Buob D, et al. Renal cell carcinoma with rhabdoid features: an aggressive neoplasm with overexpression of p53. Arch Pathol Lab Med. 2007;131:102-106.
8. Chapman-Fredricks JR, Herrera L, Bracho J, et al. Adult renal cell carcinoma with rhabdoid morphology represents a neoplastic dedifferentiation analogous to sarcomatoid carcinoma. Ann Diagn Pathol. 2011;15:333-337.
9. Shannon BA, Cohen RJ. Rhabdoid differentiation of chromophobe renal cell carcinoma. Pathology. 2003;35:228-230.
10. Brcic I, Spajic B, Kruslin B. Chromophobe renal cell carcinoma with rhabdoid differentiation in an adult. Wien Klin Wochenschr. 2012; 124:419-421.
11. Cheng JX, Tretiakova M, Gong C, et al. Renal medullary carcinoma: rhabdoid features and the absence of INI1 expression as markers of aggressive behavior. Mod Pathol. 2008;21:647-652.
12. Kuroda N, Tamura M, Hamaguchi N, et al. Acquired cystic diseaseassociated renal cell carcinoma with sarcomatoid change and rhabdoid features. Ann Diagn Pathol. 2011;15:462-466.
13. Shannon B, Stan Wisniewski Z, Bentel J, et al. Adult rhabdoid renal cell carcinoma. Arch Pathol Lab Med. 2002;126:1506-1510.
14. Versteege I, Sevenet N, Lange J, et al. Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer. Nature. 1998;394: 203-206.
15. Sigauke E, Rakheja D, Maddox DL, et al. Absence of expression of SMARCB1/INI1 in malignant rhabdoid tumors of the central nervous system, kidneys and soft tissue: an immunohistochemical study with implications for diagnosis. Mod Pathol. 2006;19: 717-725.
16. Pena-Llopis S, Vega-Rubin-de-Celis S, Liao A, et al. BAP1 loss defines a new class of renal cell carcinoma. Nat Genet. 2012;44:751-759.
17. Kapur P, Pena-Llopis S, Christie A, et al. Effects on survival of BAP1 and PBRM1 mutations in sporadic clear-cell renal-cell carcinoma: a retrospective analysis with independent validation. Lancet Oncol. 2013;14:159-167.
18. Hakimi AA, Chen YB, Wren J, et al. Clinical and pathologic impact of select chromatin-modulating tumor suppressors in clear cell renal cell carcinoma. Eur Urol. 2013;63:848-854.
19. Hakimi AA, Ostrovnaya I, Reva B, et al. Adverse outcomes in clear cell renal cell carcinoma with mutations of 3p21 epigenetic regulators BAP1 and SETD2: a report by MSKCC and the KIRC TCGA research network. Clin Cancer Res. 2013;19:3259-3267.