The rise and fall of NGAL in acute kidney injury

Blood Purification

Volumn 37, Issue 4, 2014, Pages 304-310

  Mårtensson, Johan ^a,d   Bellomo, R Rinaldo ^a,b,c  

^a AUSTIN HOSPITAL   (Australia)

^b Australian and New Zealand Intensive Care Research Centre   (Australia)

^c MONASH UNIVERSITY   (Australia)

^d KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Acute kidney injury; Inflammation; Intensive care; Neutrophil gelatinase associated lipocalin

Indexed keywords

IRON; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; ACUTE PHASE PROTEIN; BIOLOGICAL MARKER; LCN2 PROTEIN, HUMAN; LIPOCALIN; ONCOPROTEIN;

ACUTE KIDNEY FAILURE; CELL ACTIVITY; CELL FUNCTION; CRITICAL ILLNESS; CRITICALLY ILL PATIENT; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; DISEASE ASSOCIATION; DISEASE SEVERITY; HUMAN; IRON KINETICS; NONHUMAN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REVIEW; TISSUE SPECIFICITY; ACUTE KIDNEY INJURY; BLOOD; METABOLISM; TRANSPORT AT THE CELLULAR LEVEL; URINE;

ACUTE KIDNEY INJURY; ACUTE-PHASE PROTEINS; BIOLOGICAL MARKERS; BIOLOGICAL TRANSPORT; CRITICAL ILLNESS; HUMANS; IRON; LIPOCALINS; PROTO-ONCOGENE PROTEINS;

EID: 84906625660     PISSN: 02535068     EISSN: 14219735     Source Type: Journal    
DOI: 10.1159/000364937     Document Type: Review

References (67)

1. Mishra J, Ma Q, Prada A, et al: Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury . J Am Soc Nephrol 2003; 14: 2534-2543.
2. Mishra J, Mori K, Ma Q, Kelly C, Barasch J, Devarajan P: Neutrophil gelatinase-associated lipocalin: a novel early urinary biomarker for cisplatin nephrotoxicity . Am J Nephrol 2004; 24: 307-315.
3. Mishra J, Dent C, Tarabishi R, et al: Neutrophil gelatinase-associated lipocalin as a biomarker for acute renal injury after cardiac surgery . Lancet 2005; 365: 1231-1238.
4. Devarajan P: Review: neutrophil gelatinaseassociated lipocalin: a troponin-like biomarker for human acute kidney injury. Nephrology (Carlton) 2010; 15: 419-428.
5. Akcay A, Nguyen Q, Edelstein CL: Mediators of inflammation in acute kidney injury . Mediators Inflamm 2009; 2009:137072.
6. Cowland JB, Borregaard N: Molecular characterization and pattern of tissue expression of the gene for neutrophil gelatinase-associated lipocalin from humans . Genomics 1997; 45: 17-23.
7. Cai L, Rubin J, Han W, Venge P, Xu S: The origin of multiple molecular forms in urine of HNL/NGAL . Clin J Am Soc Nephrol 2010; 5: 2229-2235.
8. Kjeldsen L, Johnsen AH, Sengelov H, Borregaard N: Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase . J Biol Chem 1993; 268: 10425-10432.
9. Xu SY, Carlson M, Engstrom A, Garcia R, Peterson CG, Venge P: Purification and characterization of a human neutrophil lipocalin from the secondary granules of human neutrophils. Scand J Clin Lab Invest 1994; 54: 365-376.
10. Borregaard N, Cowland JB: Granules of the human neutrophilic polymorphonuclear leukocyte. Blood 1997; 89: 3503-3521.
11. Cowland JB, Sorensen OE, Sehested M, Borregaard N: Neutrophil gelatinase-associated lipocalin is upregulated in human epithelial cells by IL-1β, but not by TNF-α. J Immunol 2003; 171: 6630-6639.
12. Xu S, Venge P: Lipocalins as biochemical markers of disease. Biochim Biophys Acta 2000; 1482: 298-307.
13. Xu SY, Pauksen K, Venge P: Serum measurements of human neutrophil lipocalin discriminate between acute bacterial and viral infections. Scand J Clin Lab Invest 1995; 55: 125-131.
14. Fjaertoft G, Foucard T, Xu S, Venge P: Human neutrophil lipocalin as a diagnostic tool in children with acute infections: a study of the kinetics . Acta Paediatr 2005; 94: 661-666.
15. Martensson J, Xu S, Bell M, Martling CR, Venge P: Immunoassays distinguishing between HNL/NGAL released in urine from kidney epithelial cells and neutrophils . Clin Chim Acta 2012; 413: 1661-1667.
16. Schmidt-Ott KM, Mori K, Li JY, et al: Dual action of neutrophil gelatinase-associated lipocalin. J Am Soc Nephrol 2007; 18: 407-413.
17. Goetz DH, Holmes MA, Borregaard N, Bluhm ME, Raymond KN, Strong RK: The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition. Mol Cell 2002; 10: 1033-1043.
18. Flo TH, Smith KD, Sato S, et al: Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature 2004; 432: 917-921.
19. Yang J, Goetz D, Li JY, et al: An iron delivery pathway mediated by a lipocalin . Mol Cell 2002; 10: 1045-1056.
20. Mishra J, Mori K, Ma Q, et al: Amelioration of ischemic acute renal injury by neutrophil gelatinase-associated lipocalin. J Am Soc Nephrol 2004; 15: 3073-3082.
21. Mori K, Lee HT, Rapoport D, et al: Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury. J Clin Invest 2005; 115: 610-621.
22. Supavekin S, Zhang W, Kucherlapati R, Kaskel FJ, Moore LC, Devarajan P: Differential gene expression following early renal ischemia/reperfusion . Kidney Int 2003; 63: 1714-1724.
23. Zappitelli M, Washburn KK, Arikan AA, et al: Urine neutrophil gelatinase-associated lipocalin is an early marker of acute kidney injury in critically ill children: a prospective cohort study. Crit Care 2007; 11:R84.
24. Koyner JL, Vaidya VS, Bennett MR, et al: Urinary biomarkers in the clinical prognosis and early detection of acute kidney injury . Clin J Am Soc Nephrol 2010; 5: 2154-2165.
25. de Geus HR, Bakker J, Lesaffre EM, Le Noble JL: Neutrophil gelatinase-associated lipocalin at ICU admission predicts for acute kidney injury in adult patients. Am J Respir Crit Care Med 2011; 183: 907-914.
26. Kashani K, Al-Khafaji A, Ardiles T, et al: Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury. Crit Care 2013; 17:R25.
27. Haase M, Bellomo R, Devarajan P, et al: Novel biomarkers early predict the severity of acute kidney injury after cardiac surgery in adults. Ann Thorac Surg 2009; 88: 124-130.
28. Wagener G, Jan M, Kim M, et al: Association between increases in urinary neutrophil gelatinase- associated lipocalin and acute renal dysfunction after adult cardiac surgery. Anesthesiology 2006; 105: 485-491.
29. Wagener G, Gubitosa G, Wang S, Borregaard N, Kim M, Lee HT: Urinary neutrophil gelatinase- associated lipocalin and acute kidney injury after cardiac surgery. Am J Kidney Dis 2008; 52: 425-433.
30. Xin C, Yulong X, Yu C, Changchun C, Feng Z, Xinwei M: Urine neutrophil gelatinase-associated lipocalin and interleukin-18 predict acute kidney injury after cardiac surgery . Ren Fail 2008; 30: 904-913.
31. Liangos O, Tighiouart H, Perianayagam MC, et al: Comparative analysis of urinary biomarkers for early detection of acute kidney injury following cardiopulmonary bypass. Biomarkers 2009; 14: 423-431.
32. Che M, Xie B, Xue S, et al: Clinical usefulness of novel biomarkers for the detection of acute kidney injury following elective cardiac surgery. Nephron Clin Pract 2010; 115:c66-c72.
33. Parikh CR, Coca SG, Thiessen-Philbrook H, et al: Postoperative biomarkers predict acute kidney injury and poor outcomes after adult cardiac surgery . J Am Soc Nephrol 2011; 22: 1748-1757.
34. Heise D, Rentsch K, Braeuer A, Friedrich M, Quintel M: Comparison of urinary neutrophil glucosaminidase-associated lipocalin, cystatin C, and α 1 -microglobulin for early detection of acute renal injury after cardiac surgery . Eur J Cardiothorac Surg 2011; 39: 38-43.
35. Makris K, Markou N, Evodia E, et al: Urinary neutrophil gelatinase-associated lipocalin as an early marker of acute kidney injury in critically ill multiple trauma patients. Clin Chem Lab Med 2009; 47: 79-82.
36. Siew ED, Ware LB, Gebretsadik T, et al: Urine neutrophil gelatinase-associated lipocalin moderately predicts acute kidney injury in critically ill adults. J Am Soc Nephrol 2009; 20: 1823-1832.
37. Martensson J, Bell M, Oldner A, Xu S, Venge P, Martling CR: Neutrophil gelatinase-associated lipocalin in adult septic patients with and without acute kidney injury . Intensive Care Med 2010; 36: 1333-1340.
38. Metzger J, Kirsch T, Schiffer E, et al: Urinary excretion of twenty peptides forms an early and accurate diagnostic pattern of acute kidney injury . Kidney Int 2010; 78: 1252-1262.
39. Endre ZH, Pickering JW, Walker RJ, et al: Improved performance of urinary biomarkers of acute kidney injury in the critically ill by stratification for injury duration and baseline renal function . Kidney Int 2011; 79; 1119-1130.
40. de Geus HR, Fortrie G, Betjes MG, Van Schaik RH, Groeneveld AB: Time of injury affects urinary biomarker predictive values for acute kidney injury in critically ill, non-septic patients. BMC Nephrol 2013; 14: 273.
41. Koyner JL, Garg AX, Coca SG, et al: Biomarkers predict progression of acute kidney injury after cardiac surgery . J Am Soc Nephrol 2012; 23: 905-914.
42. Puthucheary ZA, Rawal J, McPhail M, et al: Acute skeletal muscle wasting in critical illness. JAMA 2013; 310: 1591-1600.
43. Liu KD, Thompson BT, Ancukiewicz M, et al: Acute kidney injury in patients with acute lung injury: impact of fluid accumulation on classification of acute kidney injury and associated outcomes. Crit Care Med 2011; 39: 2665-2671.
44. Haase M, Devarajan P, Haase-Fielitz A, et al: The outcome of neutrophil gelatinase-associated lipocalin-positive subclinical acute kidney injury: a multicenter pooled analysis of prospective studies. J Am Coll Cardiol 2011; 57: 1752-1761.
45. Nickolas TL, Schmidt-Ott KM, Canetta P, et al: Diagnostic and prognostic stratification in the emergency department using urinary biomarkers of nephron damage: a multicenter prospective cohort study. J Am Coll Cardiol 2012; 59: 246-255.
46. Mitsnefes MM, Kathman TS, Mishra J, et al: Serum neutrophil gelatinase-associated lipocalin as a marker of renal function in children with chronic kidney disease. Pediatr Nephrol 2007; 22: 101-108.
47. Bolignano D, Lacquaniti A, Coppolino G, et al: Neutrophil gelatinase-associated lipocalin and progression of chronic kidney disease. Clin J Am Soc Nephrol 2009; 4: 337-344.
48. McIlroy DR, Wagener G, Lee HT: Neutrophil gelatinase-associated lipocalin and acute kidney injury after cardiac surgery: the effect of baseline renal function on diagnostic performance. Clin J Am Soc Nephrol 2010; 5: 211-219.
49. Haase M, Bellomo R, Devarajan P, Schlattmann P, Haase-Fielitz A: Accuracy of neutrophil gelatinase-associated lipocalin in diagnosis and prognosis in acute kidney injury: a systematic review and meta-analysis. Am J Kidney Dis 2009; 54: 1012-1024.
50. Uchino S, Kellum JA, Bellomo R, et al: Acute renal failure in critically ill patients: a multinational, multicenter study. JAMA 2005; 294: 813-818.
51. Grigoryev DN, Liu M, Hassoun HT, Cheadle C, Barnes KC, Rabb H: The local and systemic inflammatory transcriptome after acute kidney injury. J Am Soc Nephrol 2008; 19: 547-558.
52. Koyner JL, Bennett MR, Worcester EM, et al: Urinary cystatin C as an early biomarker of acute kidney injury following adult cardiothoracic surgery. Kidney Int 2008; 74: 1059-1069.
53. Cai L, Borowiec J, Xu S, Han W, Venge P: Assays of urine levels of HNL/NGAL in patients undergoing cardiac surgery and the impact of antibody configuration on their clinical performances. Clin Chim Acta 2009; 403: 121-125.
54. Martensson J, Bell M, Xu S, et al: Association of plasma neutrophil gelatinase-associated lipocalin with sepsis and acute kidney dysfunction. Biomarkers 2013; 18: 349-356.
55. Nickolas TL, O'Rourke MJ, Yang J, et al: Sensitivity and specificity of a single emergency department measurement of urinary neutrophil gelatinase-associated lipocalin for diagnosing acute kidney injury. Ann Intern Med 2008; 148: 810-819.
56. Shapiro NI, Trzeciak S, Hollander JE, et al: The diagnostic accuracy of plasma neutrophil gelatinase-associated lipocalin in the prediction of acute kidney injury in emergency department patients with suspected sepsis. Ann Emerg Med 2010; 56: 52-59 e51.
57. Hvidberg V, Jacobsen C, Strong RK, Cowland JB, Moestrup SK, Borregaard N: The endocytic receptor megalin binds the iron transporting neutrophil-gelatinase-associated lipocalin with high affinity and mediates its cellular uptake. FEBS Lett 2005; 579: 773-777.
58. Kuwabara T, Mori K, Mukoyama M, et al: Urinary neutrophil gelatinase-associated lipocalin levels reflect damage to glomeruli, proximal tubules, and distal nephrons . Kidney Int 2009; 75: 285-294.
59. Awad AS, Rouse M, Huang L, et al: Compartmentalization of neutrophils in the kidney and lung following acute ischemic kidney injury. Kidney Int 2009; 75: 689-698.
60. Lerolle N, Nochy D, Guerot E, et al: Histopathology of septic shock induced acute kidney injury: apoptosis and leukocytic infiltration. Intensive Care Med 2010; 36: 471-478.
61. Glassford NJ, Schneider AG, Xu S, et al: The nature and discriminatory value of urinary neutrophil gelatinase-associated lipocalin in critically ill patients at risk of acute kidney injury. Intensive Care Med 2013; 39: 1714-1724.
62. Åberg A: Myocardial Infarctions in Sweden 1987-2005. Stockholm, Official Statistics of Sweden, 2008, pp 1-102.
63. Mahadavan G, Nguyen TH, Horowitz JD: Brain natriuretic peptide: a biomarker for all cardiac disease? Curr Opin Cardiol 2014; 29: 160-166.
64. Mercier E, Boutin A, Lauzier F, et al: Predictive value of S-100β protein for prognosis in patients with moderate and severe traumatic brain injury: systematic review and metaanalysis. BMJ 2013; 346:f1757.
65. Taccone FS, Cronberg T, Friberg H, et al: How to assess prognosis after cardiac arrest and therapeutic hypothermia. Crit Care 2014; 18: 202.
66. Markou N, Gregorakos L, Myrianthefs P: Increased blood troponin levels in ICU patients. Curr Opin Crit Care 2011; 17: 454-463.
67. Noveanu M, Mebazaa A, Mueller C: Cardiovascular biomarkers in the ICU. Curr Opin Crit Care 2009; 15: 377-383.