Targeted genome correction by a single adenoviral vector simultaneously carrying an inducible zinc finger nuclease and a donor template

Journal of Biotechnology

Volumn 188, Issue , 2014, Pages 1-6

  Zhang, Weifeng ^a   Chen, Hao ^a   Zheng, Xiaojing ^a   Wang, Dongyang ^a   Ji, Haiyan ^a   Xia, Haibin ^a   Mao, Qinwen ^b  

^a SHAANXI NORMAL UNIVERSITY   (China)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Adenoviral vector; Genome editing; Homologous recombination; Site specific integration; Zinc finger nuclease

Indexed keywords

VECTORS; ZINC;

ADENOVIRAL VECTORS; ATTRACTIVE STRATEGIES; DELIVERY SYSTEMS; EXPRESSION CASSETTE; GENE CORRECTION; HOMOLOGOUS RECOMBINATION; SITE-SPECIFIC; ZINC FINGER NUCLEASE;

GENES;

ADENOVIRUS VECTOR; GENOMIC DNA; ZINC FINGER NUCLEASE; DEOXYRIBONUCLEASE; ZINC FINGER PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DONOR; EX VIVO STUDY; GENE CASSETTE; GENE EXPRESSION; GENE MUTATION; GENOME; HEK293 CELL LINE; HOMOLOGOUS RECOMBINATION; HUMAN; HUMAN ADENOVIRUS 5; IN VITRO STUDY; MONOGENIC DISORDER; MOUSE; NONHUMAN; PRIORITY JOURNAL; SHUTTLE VECTOR; VIRAL GENE DELIVERY SYSTEM; ADENOVIRIDAE; CELL LINE; GENE VECTOR; GENETICS; MUTAGENESIS; ANIMAL TISSUE; BIOLUMINESCENCE; DNA TEMPLATE; HUMAN CELL; MUTATION RATE; PROMOTER REGION; PROTEIN EXPRESSION; TARGETED GENE REPAIR; VIRUS INFECTION; VIRUS TITRATION;

ADENOVIRIDAE; CELL LINE; DEOXYRIBONUCLEASES; GENETIC VECTORS; GENOME; HUMANS; MUTAGENESIS; ZINC FINGERS;

EID: 84906502034     PISSN: 01681656     EISSN: 18734863     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2014.08.003     Document Type: Article

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