Cord blood procalcitonin and Interleukin-6 are highly sensitive and specific in the prediction of early-onset sepsis in preterm infants

Scandinavian Journal of Clinical and Laboratory Investigation

Volumn 74, Issue 5, 2014, Pages 432-436

  Steinberger, Eva ^a   Hofer, Nora ^a   Resch, Bernhard ^a  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

Cord blood; Early onset sepsis; Interleukin 6; Preterm infant; Procalcitonin

Indexed keywords

INTERLEUKIN 6; PROCALCITONIN; BIOLOGICAL MARKER; CALCITONIN; IL6 PROTEIN, HUMAN; PROTEIN PRECURSOR;

ARTICLE; BLOOD CULTURE; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; FEMALE; HUMAN; INFANT; INFECTION RISK; LIMIT OF DETECTION; MAJOR CLINICAL STUDY; MALE; NEWBORN; PREDICTIVE VALUE; PREMATURITY; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; SEPSIS; UMBILICAL CORD BLOOD; YOUDEN INDEX; AREA UNDER THE CURVE; BLOOD; FETUS BLOOD; METABOLISM; RECEIVER OPERATING CHARACTERISTIC; RETROSPECTIVE STUDY;

AREA UNDER CURVE; BIOLOGICAL MARKERS; CALCITONIN; FEMALE; FETAL BLOOD; HUMANS; INFANT, NEWBORN; INFANT, PREMATURE; INTERLEUKIN-6; MALE; PROTEIN PRECURSORS; RETROSPECTIVE STUDIES; ROC CURVE; SEPSIS;

EID: 84906275559     PISSN: 00365513     EISSN: 15027686     Source Type: Journal    
DOI: 10.3109/00365513.2014.900696     Document Type: Article

References (21)

1. Dear P. Infection in the newborn. In: Rennie J, editor. Robertons textbook of neonatology. 4th ed. London: Elsevier Ltd; 2005. pp. 1011-75.
2. Schuchat A, Zywicki SS, Dinsmoor MJ, Mercer B, Romaguera J, O'Sullivan MJ, Patel D, Peters MT, Stoll B, Levine OS. Risk factors and opportunities for prevention of early-onset neonatal sepsis: a multicenter case-control study. Pediatrics 2000; 105: 21-6.
3. Isaacs D, Barfield CP, Grimwood K, McPhee AJ, Minutillo C, Tudehope DI. Systemic bacterial and fungal infections in infants in Australian neonatal units. Australian Study Group for Neonatal Infections. Med J Aust 1995; 162: 198-201.
4. Chiesa C, Pacifico L, Mancuso G, Panero A. Procalcitonin in pediatrics: overview and challenge. Infection 1998; 26: 236-41.
5. Llorente E, Prieto B, Cardo L, Avello N, Alvarez F V. Umbilical cord blood serum procalcitonin by Time-Resolved Amplified Cryptate Emission (TRACE) technology: reference values of a potential marker of vertically transmitted neonatal sepsis. Clin Chem Lab Med 2007; 45: 1531-5.
6. Saez-Llorens X, McCraecken G. Perinatal bacterial infection. In: Feigin RA, Cherry JD, Demmler GJ, Kaplan SL, editors. Textbook of pediatric infectious diseases. 6th ed. Philadelphia, PA: Saunders; 2009. pp. 926-66.
7. Stocker M, Hop WC, van Rossum AM. Neonatal Procalcitonin Intervention Study (NeoPInS): Effect of procalcitonin-guided decision making on duration of antibiotic therapy in suspected neonatal early-onset sepsis: a multi-centre randomized superiority and non-inferiority intervention study. BMC Pediatr 2010; 10: 89.
8. Lam HS, Ng P C. Biochemical markers of neonatal sepsis. Pathology (Phila) 2008; 40: 141-8.
9. Maruna P, NedelníkováK, Gürlich R. Physiology and genetics of procalcitonin. Physiol Res Acad Sci Bohemoslov 2000; 49: S57-61.
10. Bruins P, te Velthuis H, Yazadankbakhsh AP, Jansen P GM, van Hardevelt FWJ, de Beaumont EM, Wildevuur CR, Eijsman L, Trouwborst A, Hack CE. Activation of the complement system during and after cardiopulmonary bypass surgery. Circulation 1997: 96: 3542-8.
11. Bossuyt PM. Clinical validity: defi ning biomarker performance. Scand J Clin Lab Invest 2010; 70(Suppl. 242): S46-52.
12. Benitz W E. Adjunct laboratory diagnosis of early-onset neonatal sepsis. Clin Perinatol 2010; 37: 421-38.
13. Chiesa C, Panero A, Rossi N, Stegagno M, De Giusti M, Osborn JF, Pacifico L. Reliability of procalcitonin concentrations for the diagnosis of sepsis in critically ill neonates. Clin Infect Dis 1998; 26: 664-72.
14. Turner D, Hammerman C, Rudensky B, Schlesinger Y, Goia C, Schimmel MS. Procalcitonin in preterm infants during the fi rst few days of life: introducing an age related nomogram. Arch Dis Child Fetal Neonatal Ed 2006; 91: F283-6.
15. Chiesa C, Natale F, Pascone R, Osborn JF, Pacifico L, Bonci E, De Curtis M. Creactive protein and procalcitonin: reference intervals for preterm and term newborns during the early neonatal period. Clin Chim Acta 2011; 412: 1053-9.
16. Hofer N, Resch B. CRP in term and preterm newborns. Clin Chim Acta 2011; 412: 1888.
17. Hofer N, Zacharias E, Müller W, Resch B. An update on the use of C-reactive protein iNearly-onset neonatal sepsis: current insights and new tasks. Neonatology 2012; 102: 25-36.
18. Fan Y, Yu JL. Umbilical blood biomarkers for predicting early-onset neonatal sepsis. World J Pediatr 2012; 8: 101-8.
19. Joram N, Muller JB, Denizot S, Orsonneau JL, Caillon J, Rozé JC, Gras-Le Guen C. Umbilical cord blood procalcitonin level iNearly neonatal infections: a 4-year university hospital cohort study. Eur J Clin Microbiol Infect Dis 2011; 30: 1005-13.
20. Joram N, Boscher C, Denizot S, Loubersac V, Winer N, Roze JC, Gras-Le Guen C. Umbilical cord blood procalcitonin and Creactive protein concentrations as markers for early diagnosis of very early onset neonatal infection. Arch Dis Child Fetal Neonatal Ed 2006; 91: F65-6.
21. Mussap M, Noto A, Cibecchini F, Fanos V. The importance of biomarkers in neonatology. Semin Fetal Neonatal Med 2013; 18: 56-64.