Haplotype and nucleotide variation in the exon 3-VNTR of the DRD4 gene from indigenous and urban populations of Mexico

American Journal of Human Biology

Volumn 26, Issue 5, 2014, Pages 682-689

  Aguirre Samudio, Ana Julia ^a,b   Cruz Fuentes, Carlos Sabás ^a   González Sobrino, Blanca Zoila ^b   Gutiérrez Pérez, Verónica ^a   Medrano González, Luis ^b  

^a INSTITUTO NACIONAL DE PSIQUIATRÍA RAMÓN DE LA FUENTE MUÑIZ   (Mexico)

^b UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE 4 RECEPTOR; DRD4 PROTEIN, HUMAN;

AMERICAN INDIAN; BLOOD; CHEMISTRY; DNA SEQUENCE; EXON; GENE FREQUENCY; GENETIC POLYMORPHISM; GENETICS; HAPLOTYPE; HUMAN; MEXICO; MOLECULAR GENETICS; PHYLOGENY; POLYMERASE CHAIN REACTION; SALIVA; URBAN POPULATION; VARIABLE NUMBER OF TANDEM REPEAT;

EXONS; GENE FREQUENCY; HAPLOTYPES; HUMANS; INDIANS, NORTH AMERICAN; MEXICO; MINISATELLITE REPEATS; MOLECULAR SEQUENCE DATA; PHYLOGENY; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; RECEPTORS, DOPAMINE D4; SALIVA; SEQUENCE ANALYSIS, DNA; URBAN POPULATION;

EID: 84906263325     PISSN: 10420533     EISSN: 15206300     Source Type: Journal    
DOI: 10.1002/ajhb.22581     Document Type: Article

References (34)

1. Aguirre AJ, Apiquián R, Fresán A, Cruz-Fuentes C. 2007. Association analysis of exon III and exon I polymorphisms of the dopamine D4 receptor locus in Mexican psychotic patients. Psychiatry Res 153:209-15.
2. Behar DM, Villems R, Soodyall H, Blue-Smith J, Pereira L, Metspalu E, Scozzari R, Makkan H, Tzur S, Comas D, Bertranpetit J, Quintana-Murci L, Tyler-Smith C, Spencer Wells R, Rosset S, The Genographic Consortium. 2008. The dawn of human matrilineal diversity. Am J Hum Genet 82:1130-1140.
3. Benjamin J, Osher Y, Kotler M, Gritsenko I, Nemanov L, Belmaker RH, Ebstein RP. 2000. Association between tridimensional personality questionnaire (TPQ) traits and three functional polymorphism: dopamine receptor D4 (DRD4), serotonin transporter promoter region (5-HTTLPR) and catechol O-methyltransferase (COMT). Mol Psychiatry 5:96-100.
4. Bhaduri N, Das M, Das AB, Mukhopadhyay K. 2007. Dopamine receptor D4 exon 3 variable number of tandem repeat polymorphism: distribution in eastern Indian population. Indian J Hum Genet 13:54-58.
5. Chang F-M, Kidd JR, Livak KJ, Pakstis AJ, Kidd KK. 1996. The worldwide distribution of allele frequencies at the human dopamine D4 receptor locus. Hum Genet 98:91-101.
6. Chen C, Burton M, Greenberger E, Dmitrieva J. 1999. Population migration and the variation of dopamine D4 receptor (DRD4) allele frequencies around the globe. Evol Hum Behav 20:309-324.
7. Ding YC, Chi HC, Grady DL, Morishima A, Kidd JR, Kidd KK, Flodman P, Spence MA, Flodman P, Spence MA, Schuck S. Swanson JM, Zhang JP, Moyzis RK. 2002. Evidence of positive selection acting at the human dopamine receptor D4 gene locus. Proc Natl Acad Sci USA 99:309-314.
8. Du Y, Yang M, Yeh HW, Wan YJ. 2010. The association of exon 3 VNTR polymorphism of the dopamine receptor D4 (DRD4) gene with alcoholism in Mexican Americans. Psychiatry Res 177:358-60.
9. Ebstein RP, Novick O, Umansky R, Pirlli B, Osher Y, Blaine D, Bennett ER, Nemanov L, Katz M, Belmaker RH. 1996. Dopamine D4 receptor exon III polymorphism associated with the human personality trait of novelty seeking. Nat Genet 12:78-80.
10. Excoffier L, Laval G, Schneider S. 2005. Arlequin ver. 3.0: an integrated software package for population genetics data analysis. Evol Bioinform Online 1:47-50.
11. Ghosh A, Seshadri M. 2005. Indian ethnic populations characterized by dopamine (D4) receptor VNTR polymorphism. Ann Hum Biol 32:574-584.
12. González Sobrino BZ. 2012. Locura y trastornos mentales. In: González Sobrino BZ, editor. Entre tarahumaras, coras y huicholes: algunos aspectos sobre la locura. Mexico: UNAM. p 15-43.
13. González Sobrino BZ, Pintado Cortina AP. 2012. Las huellas del andar rarámuri: aspectos históricos y genéticos en la región tarahumara. In: González Sobrino BZ, editor. Entre tarahumaras, coras y huicholes: algunos aspectos sobre la locura. Mexico: UNAM. p 175-214.
14. Gorostiza A, Acunha-Alonzo V, Regalado-Liu L, Tirado S, Granados J, Sámano D, Rangel-Villalobos H, González-Martín A. 2012. Reconstructing the history of Mesoamerican populations through the study of the mitochondrial DNA control region. PloS One 7:e44666.
15. Grady DL, Harxhi A, Smith M, Flodman P, Spence MA, Swanson JM, Moyzis RK. 2005. Sequence variants of the DRD4 gene in autism: further evidence that rare DRD4 7R haplotypes are ADHD specific. Am J Med Genet B Neuropsychiatr Genet 136B:33-35.
16. Grady DL, Smith M, Wang E, Schuck S, Flodman P, Spence MA, Swanson JM, Moyzis RK. 2003. High prevalence of rare dopamine receptor D4 alleles in children diagnosed with attention-deficit hyperactivity disorder. Mol Psychiatry 8:536-545.
17. Hall T. 2005. BioEdit: Biological Sequence Alignment Editor for Windows 95/98/NT/XP.
18. Hattori E, Nakajima M, Yamada K, Iwayama Y, Toyota T, Saitou N, Yoshikawa T. 2009. Variable number of tandem repeat polymorphisms of DRD4: re-evaluation of selection hypothesis and analysis of association with schizophrenia. Eur J Hum Genet 17: 793-801.
19. Lichter JB, Barr CL, Kennedy JL, Van Tol HH, Kidd KK, Livak KJ. 1993. A hypervariable segment in the human dopamine receptor D4 (DRD4) gene. Hum Mol Genet 2:767-773.
20. Martínez-Levy G, Díaz-Galvis J, Briones-Velasco M, Gómez-Sánchez A, De la Peña-Olvera F, Sosa-Mora L, Palacios-Cruz L, Ricardo-Garcell J, Reyes-Zamorano E, Cruz-Fuentes C. 2009. Genetic interaction analysis for DRD4 and DAT1 genes in a group of Mexican ADHD patients. Neurosci Lett 451:257-260.
21. Martinez-Marignac VL, Valladares A, Cameron E, Chan A, Perera A, Globus-Goldberg R, Wacher N, Kumate J, McKeigue P, O'Donnell D, Shriver MD, Cruz M, Parra EJ. 2007. Admixture in Mexico City: implications for admixture mapping of type 2 diabetes genetic risk factors. Hum Genet 120:807-819; DOI 10.1007/s00439-006-0273-3.
22. Matthews LJ, Butler PM. 2011. Novelty-seeking DRD4 polymorphisms are associated with human migration distance out-of-Africa after controlling for neutral population gene structure. Am J Phys Anthropol 145:382-389.
23. Muñoz LM, Ramos E, Díaz-Badillo A, Morales-Gómez MC, Gómez R, Pérez-Ramírez G. 2012. Migration of pre-Hispanic and contemporary human Mexican populations. In: Crawford MH, Campbell BC, editors. Causes and consequences of human migration. An evolutionary perspective. Cambridge: Cambridge University Press. p 417-435.
24. Naka I, Nishida N, Ohashi J. 2011. No evidence for strong recent positive selection favoring the 7 repeat allele of VNTR in the DRD4 gene. PloS One 6:e24410.
25. Nicolini H, Sidenberg D, Camarena B, Guerra C, Monteiro Grazina M, Petronis A, Kennedy J. 1993. Dopaminergic system genes in Mexican schizophrenics. Rev Invest Clin 45:345-352.
26. Ronquist F, Huelsenbeck JP. 2003. MrBayes 3: Bayesian phylogenetic inference under mixed models. Bioinformatics 19:1572-1574.
27. Silva-Zolezzi I, Hidalgo-Miranda A, Estrada-Gil J, Fernandez-Lopez JC, Uribe-Figueroa L, Contreras A, Balam-Ortiz E, Del Bosque-Plata L, Velazquez-Fernandez D, Lara C, Goya R, Hernandez-Lemus E, Davila C, Barrientos E, March S, Jimenez-Sanchez G. 2009. Analysis of genomic diversity in Mexican Mestizo populations to develop genomic medicine in Mexico. Proc Natl Acad Sci USA 106:8611-8616.
28. Swanson JM, Flodman, P, Kennedy J, Spence MA, Moyzis R, Schuck S, Murias M, Moriarity J, Barr C, Smith M, Posner M. 2000. Dopamine genes and ADH. Neurosci Biobehav Rev 24:21-25.
29. Tovo-Rodrigues L, Callegari-Jacques SM, Petzl-Erler ML, Tsuneto L, Salzano FM, Hutz MH. 2010. Dopamine receptor D4 allele distribution in Amerindians: a reflection of past behavior differences? Am J Physical Anthropol 143:458-464.
30. Tovo-Rodrigues L, Rohde LA, Roman T, Schmitz M, Polanczyk G, Zeni C, Marques FZC, Contini V, Grevet EH, Belmonte-de-Abreu P, Bau CHD and Hutz MH. 2012. Is there a role for rare variants in DRD4 gene in the susceptibility for ADHD? Searching for an effect of allelic heterogeneity. Mol Psychiatry 17:520-526.
31. Underhill PA, Kivisild T. 2007. Use of Y chromosome and mitochondrial DNA population structure in tracing human migrations. Annu Rev Genet 41:539-564.
32. Van Tol H, Bunzow JR, Guan H, Sunahara R, Seeman P, Niznik HB, Civelli O. 1991. Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine. Nature 350:610-614.
33. Vieyra G, Moraga M, Henríquez H, Aboitiz F, Rothhammer F. 2003. Distribution of alleles of DRD4 and DAT1 genes of the dopaminergic system in the mixed Chilean population. Rev Med Chil 131:135-143.
34. Wang E, Ding Y-C, Flodman P, Kidd JR, Kidd K, Grady DL, Ryder O, Spence MA, Swanson JM, Moyzis RK. 2004. The genetic architecture of selection at the human dopamine receptor D4 (DRD4) gene locus. Am J Hum Genet 74: 931-944.