Analysis of rare variant population structure in Europeans explains differential stratification of gene-based tests

European Journal of Human Genetics

Volumn 22, Issue 9, 2014, Pages 1137-1144

  Zawistowski, Matthew ^a   Reppell, Mark ^a   Wegmann, Daniel ^b   St Jean, Pamela L ^c   Ehm, Margaret G ^c   Nelson, Matthew R ^c   Novembre, John ^d   Zöllner, Sebastian ^a,e  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF FRIBOURG   (Switzerland)

^c GLAXOSMITHKLINE   (United States)

^d UNIVERSITY OF CHICAGO   (United States)

^e UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

burden tests; population stratification; rare variants; site frequency spectra; type I error

Indexed keywords

ARTICLE; GENETIC ANALYSIS; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HUMAN; POPULATION DIFFERENTIATION; POPULATION DISTRIBUTION; POPULATION GENETIC STRUCTURE; POPULATION RESEARCH; PRIORITY JOURNAL; AFRICAN AMERICAN; ALLELE; CENTRAL EUROPEAN; CONTROLLED STUDY; EUROPEAN; GENE CONTROL; GENE FREQUENCY; GENETIC CORRELATION; GENETIC TRAIT; GENOTYPE; HAPLOTYPE; JOINT SITE FREQUENCY SPECTRA; NORTHERN EUROPEAN; PHENOTYPE; POPULATION GENETICS; POPULATION GROWTH; PROBABILITY; SAMPLE SIZE; SEQUENCE ANALYSIS; SIMULATION; SOUTH ASIAN; WESTERN EUROPEAN; BIOLOGICAL MODEL; CAUCASIAN; GENETIC POLYMORPHISM; GENETIC SCREENING; GENETICS; PROCEDURES; STANDARDS; STATISTICAL ANALYSIS;

DATA INTERPRETATION, STATISTICAL; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENE FREQUENCY; GENETIC TESTING; HUMANS; MODELS, GENETIC; POLYMORPHISM, GENETIC;

EID: 84906262908     PISSN: 10184813     EISSN: 14765438     Source Type: Journal    
DOI: 10.1038/ejhg.2013.297     Document Type: Article

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