Destruction of DDIT3/CHOP protein by wild-type SPOP but not prostate cancer-associated mutants

Human Mutation

Volumn 35, Issue 9, 2014, Pages 1142-1151

  Zhang, Pingzhao ^a,b   Gao, Kun ^a   Tang, Yan ^a   Jin, Xiaofeng ^a   An, Jian ^c   Yu, Hongxiu ^b   Wang, Huan ^d   Zhang, Yuanyuan ^a   Wang, Dejie ^e   Huang, Haojie ^c   Yu, Long ^a,b   Wang, Chenji ^a  

^a FUDAN UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

^c MAYO GRADUATE SCHOOL   (United States)

^d CHINA MEDICAL UNIVERSITY   (China)

^e NANCHANG UNIVERSITY   (China)

Author keywords

DDIT3; Endoplasmic reticulum stress; Prostate cancer; Proteasomal degradation; SPOP

Indexed keywords

ADAPTOR PROTEIN; CUL3 RBX1 E3 UBIQUITIN LIGASE COMPLEX; CULLIN; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; PROTEASOME; SMALL INTERFERING RNA; SPECKLE TYPE POZ PROTEIN; UBIQUITIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; CARRIER PROTEIN; CUL3 PROTEIN, HUMAN; MULTIPROTEIN COMPLEX; NUCLEAR PROTEIN; PROTEIN BINDING; RBX1 PROTEIN, HUMAN; REPRESSOR PROTEIN; SPOP PROTEIN, HUMAN;

AMINO TERMINAL SEQUENCE; APOPTOSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL LYSATE; DOWN REGULATION; ENDOPLASMIC RETICULUM STRESS; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; LNCAP CELL LINE; PATHOGENESIS; POINT MUTATION; PRIORITY JOURNAL; PROSTATE CANCER; PROTEASOMAL DEGRADATION; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOMATIC MUTATION; TRANSACTIVATION; UBIQUITINATION; WILD TYPE; AMINO ACID SEQUENCE; CHEMISTRY; GENETIC TRANSCRIPTION; GENETICS; MALE; METABOLISM; MUTATION; PROSTATE TUMOR; PROTEIN DOMAIN; PROTEIN MOTIF;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; APOPTOSIS; CARRIER PROTEINS; CULLIN PROTEINS; ENDOPLASMIC RETICULUM STRESS; HUMANS; MALE; MULTIPROTEIN COMPLEXES; MUTATION; NUCLEAR PROTEINS; PROSTATIC NEOPLASMS; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEOLYSIS; REPRESSOR PROTEINS; TRANSCRIPTION FACTOR CHOP; TRANSCRIPTION, GENETIC; UBIQUITINATION;

EID: 84906062096     PISSN: 10597794     EISSN: 10981004     Source Type: Journal    
DOI: 10.1002/humu.22614     Document Type: Article

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