Development and validation of a new algorithm for the reclassification of genetic variants identified in the BRCA1 and BRCA2 genes

Breast Cancer Research and Treatment

Volumn 147, Issue 1, 2014, Pages 119-132

  Pruss, Dmitry ^a   Morris, Brian ^a   Hughes, Elisha ^a   Eggington, Julie M ^a   Esterling, Lisa ^a   Robinson, Brandon S ^a   Van Kan, Aric ^a   Fernandes, Priscilla H ^a   Roa, Benjamin B ^a   Gutin, Alexander ^a   Wenstrup, Richard J ^a   Bowles, Karla R ^a  

^a Myriad Genetic Laboratories   (United States)

Author keywords

BRCA1; BRCA2; Breast cancer; Ovarian cancer; Variant classification

Indexed keywords

ARTICLE; BREAST CANCER; CANCER CLASSIFICATION; CANCER GENETICS; FAMILY HISTORY; GENE MUTATION; GENETIC ALGORITHM; GENETIC ANALYSIS; GENETIC VARIABILITY; HIGH RISK PATIENT; HISTORY WEIGHTING ALGORITHM; HUMAN; PENETRANCE; PREDICTIVE VALUE; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE; VALIDATION PROCESS; ALGORITHM; BREAST TUMOR; CANCER STAGING; CASE CONTROL STUDY; CLASSIFICATION; CONTROLLED STUDY; FEMALE; GENETIC PREDISPOSITION; GENETIC SCREENING; GENETICS; PROGNOSIS; RANDOMIZED CONTROLLED TRIAL;

BRCA1 PROTEIN; BRCA1 PROTEIN, HUMAN; BRCA2 PROTEIN; BRCA2 PROTEIN, HUMAN;

ALGORITHMS; BRCA1 PROTEIN; BRCA2 PROTEIN; BREAST NEOPLASMS; CASE-CONTROL STUDIES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETIC TESTING; GENETIC VARIATION; HUMANS; NEOPLASM STAGING; PROGNOSIS;

EID: 84906056445     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-014-3065-9     Document Type: Article

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