Mucosal environmental sensors in the pathogenesis of dry eye

Expert Review of Clinical Immunology

Volumn 10, Issue 9, 2014, Pages 1137-1140

  Pflugfelder, Stephen C ^a   Stern, Michael E ^a,b  

^a CULLEN EYE INSTITUTE   (United States)

^b ALLERGAN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTIVE IMMUNITY; CONFERENCE PAPER; DENDRITIC CELL; DRY EYE; ENVIRONMENTAL STRESS; EPITHELIUM CELL; EYE INFLAMMATION; HUMAN; MUCOSA; PATHOGENESIS; SURFACE PROPERTY; ADVERSE EFFECTS; ANIMAL; CELL DIFFERENTIATION; ENVIRONMENTAL EXPOSURE; EYE; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; INFLAMMATION; MICROBIOLOGY; MICROFLORA; MUCOSAL IMMUNITY; UNITED STATES;

ANIMALS; CELL DIFFERENTIATION; DENDRITIC CELLS; DRY EYE SYNDROMES; ENVIRONMENTAL EXPOSURE; EYE; HUMANS; IMMUNE TOLERANCE; IMMUNITY, MUCOSAL; INFLAMMATION; MICROBIOTA; UNITED STATES;

EID: 84906055507     PISSN: 1744666X     EISSN: 17448409     Source Type: Journal    
DOI: 10.1586/1744666X.2014.944163     Document Type: Conference Paper

References (10)

1. Khandelwal P, Blanco-Mezquita T, Emami P, et al. Ocular mucosal CD11b+ and CD103+ mouse dendritic cells under normal conditions and in allergic immune responses. PLoS One 2013;8(5):e64193
2. Zhang X, Volpe EA, Gandhi NB, et al. NK cells promote Th-17 mediated corneal barrier disruption in dry eye. PLoS One 2012;7(5):e36822
3. Shembade N, Ma A, Harhaj EW. Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes. Science 2010;327(5969): 1135-9
4. Saban DR. The chemokine receptor ccr7 expressed by dendritic cells: a key player in corneal and ocular surface inflammation. Ocul Surf 2014;12(2):87-99
5. Schaumburg CS, Siemasko KF, De Paiva CS, et al. Ocular surface APCs are necessary for autoreactive T cell-mediated experimental autoimmune lacrimal keratoconjunctivitis. J Immunol 2011; 187(7):3653-62
6. DePaiva CS, Villarreal AL, Corrales RM, et al. Dry eye-induced conjunctival epithelial squamous metaplasia is modulated by interferon-gamma. Invest Ophthalmol Vis Sci 2007;48:2553-60
7. De Paiva CS, Chotikavanich S, Pangelinan SB, et al. IL-17 disrupts corneal barrier following desiccating stress. Mucosal Immunol 2009;2:243-53
8. Stern ME, Schaumburg CS, Gao J, et al. Plasmacytoid dendritic cells are the primary source of IFN-a during the immunopathogenesis of desiccating stress-induced dry eye disease. Association for Research in Vision and Ophthalmology. May, 2013. Program#/Poster# 4323/C0061
9. Stern ME, Schaumburg CS, Gao J, et al. Plasmacytoid Dendritic Cells are Modulated During the Immunopathogenesis of Desiccating Stress-Induced Experimental Dry Eye Disease. Association for Research in Vision and Ophthalmology, May, 2012. Program#/Poster# 2327/A344'
10. Koh YT, Scatizzi JC, Gahan JD, et al. Role of nucleic acid-sensing TLRs in diverse autoantibody specificities and anti-nuclear antibody-producing B cells. J Immunol 2013;190(10):4982-90