An evaluation of the sensitivity of MRI at detecting hepatocellular carcinoma in cirrhotic patients utilizing an explant reference standard

Clinical Imaging

Volumn 38, Issue 5, 2014, Pages 693-697

  Hanna, Robert F ^a   Ward, Thomas J ^b   Chow, Daniel S ^a   Lagana, Stephen M ^a   Moreira, Roger K ^a   Emond, Jean C ^a   Weintraub, Joshua L ^a   Prince, Martin R ^a  

^a Columbia University Dept of Radiology ^*  (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Biostatistics; Hepatocellular carcinoma; Liver transplantation; Magnetic resonance imaging

Indexed keywords

MEDICAL IMAGING; RADIOLOGY;

BIOSTATISTICS; HEPATOCELLULAR CARCINOMA; LIVER TRANSPLANTATION; REFERENCE STANDARD;

MAGNETIC RESONANCE IMAGING;

GADOBENATE DIMEGLUMINE;

ADULT; AGED; ARTICLE; CANCER SIZE; CANCER STAGING; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; FALSE NEGATIVE RESULT; FALSE POSITIVE RESULT; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; PREDICTIVE VALUE; PREOPERATIVE EVALUATION; PRIORITY JOURNAL; REFERENCE VALUE; RETROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY; CARCINOMA, HEPATOCELLULAR; COMPLICATION; DIFFERENTIAL DIAGNOSIS; FOLLOW UP; LIVER NEOPLASMS; MIDDLE AGED; PROCEDURES; RECEIVER OPERATING CHARACTERISTIC; REPRODUCIBILITY; YOUNG ADULT;

ADULT; AGED; CARCINOMA, HEPATOCELLULAR; DIAGNOSIS, DIFFERENTIAL; FEMALE; FOLLOW-UP STUDIES; HUMANS; LIVER CIRRHOSIS; LIVER NEOPLASMS; LIVER TRANSPLANTATION; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; NEOPLASM STAGING; REFERENCE VALUES; REPRODUCIBILITY OF RESULTS; RETROSPECTIVE STUDIES; ROC CURVE; YOUNG ADULT;

EID: 84906046704     PISSN: 08997071     EISSN: 18734499     Source Type: Journal    
DOI: 10.1016/j.clinimag.2014.05.014     Document Type: Article

References (26)

1. Wong LL Current status of liver transplantation for hepatocellular cancer. Am J Surg 2002, 183(3):309-316.
2. Yu EW, Chie WC, Chen TH Does screening or surveillance for primary hepatocellular carcinoma with ultrasonography improve the prognosis of patients?. Cancer J 2004, 10(5):317-325.
3. Bruix J, Sherman M Management of hepatocellular carcinoma. Hepatology 2005, 42(5):1208-1236.
4. Burrel M, Llovet JM, Ayuso C, Iglesias C, Sala M, Miquel R, Caralt T, Ayuso JR, Sole M, Sanchez M, Bru C, Bruix J MRI angiography is superior to helical CT for detection of HCC prior to liver transplantation: an explant correlation. Hepatology 2003, 38(4):1034-1042.
5. Mazzaferro V, Regalia E, Doci R, Andreola S, Pulvirenti A, Bozzetti F, Montalto F, Ammatuna M, Morabito A, Gennari L Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. N Engl J Med 1996, 334(11):693-699.
6. Trotter JF Selection of donors and recipients for living donor liver transplantation. Liver Transpl 2000, 6(6 Suppl 2):S52-S58.
7. Freeman RB, Mithoefer A, Ruthazer R, Nguyen K, Schore A, Harper A, Edwards E Optimizing staging for hepatocellular carcinoma before liver transplantation: a retrospective analysis of the UNOS/OPTN database. Liver Transpl 2006, 12(10):1504-1511.
8. Befeler AS, Hayashi PH, Di Bisceglie AM Liver transplantation for hepatocellular carcinoma. Gastroenterology 2005, 128(6):1752-1764.
9. Bharat A, Brown DB, Crippin JS, Gould JE, Lowell JA, Shenoy S, Desai NM, Chapman WC Pre-liver transplantation locoregional adjuvant therapy for hepatocellular carcinoma as a strategy to improve longterm survival. J Am Coll Surg 2006, 203(4):411-420.
10. United Network for Organ Sharing.Organ Distribution Allocation of Livers. Policy 3.6 Organ Distribution: Allocation of Livers. Revised November 9, 2010 Available at:, [Accessed: December 20, 2010]. http://optn.transplant.hrsa.gov/policiesAndBylaws/policies.asp.
11. Libbrecht L, Bielen D, Verslype C, Vanbeckevoort D, Pirenne J, Nevens F, Desmet V, Roskams T Focal lesions in cirrhotic explant livers: pathological evaluation and accuracy of pretransplantation imaging examinations. Liver Transpl 2002, 8(9):749-761.
12. Hanna RF, Kased N, Kwan SW, Gamst AC, Santosa AC, Hassanein T, Sirlin CB Double-contrast MRI for accurate staging of hepatocellular carcinoma in patients with cirrhosis. AJR 2008, 190(1):47-57.
13. Colli A, Fraquelli M, Casazza G, Massironi S, Colucci A, Conte D, Duca P Accuracy of ultrasonography, spiral CT, magnetic resonance, and alpha-fetoprotein in diagnosing hepatocellular carcinoma: a systematic review. Am J Gastroenterol 2006, 101(3):513-523.
14. Matsuo M, Kanematsu M, Itoh K, Murakami T, Maetani Y, Kondo H, Goshima S, Kako N, Hoshi H, Konishi J, Moriyama N, Nakamura H Detection of malignant hepatic tumors with ferumoxides-enhanced MRI: comparison of five gradient-recalled echo sequences with different TEs. AJR 2004, 182(1):235-242.
15. Bhartia B, Ward J, Guthrie JA, Robinson PJ Hepatocellular carcinoma in cirrhotic livers: double-contrast thin-section MR imaging with pathologic correlation of explanted tissue. AJR 2003, 180(3):577-584.
16. Ward J, Guthrie JA, Scott DJ, Atchley J, Wilson D, Davies MH, Wyatt JI, Robinson PJ Hepatocellular carcinoma in the cirrhotic liver: double-contrast MR imaging for diagnosis. Radiology 2000, 216(1):154-162.
17. Efron B Better bootstrap confidence intervals. J Am Stat Assoc 1987, 82(397):171-200.
18. Shah SA, Tan JC, McGilvray ID, Cattral MS, Cleary SP, Levy GA, Greig PD, Grant DR Accuracy of staging as a predictor for recurrence after liver transplantation for hepatocellular carcinoma. Transplantation 2006, 81(12):1633-1639.
19. Valls C, Cos M, Figueras J, Andia E, Ramos E, Sanchez A, Serrano T, Torras J Pretransplantation diagnosis and staging of hepatocellular carcinoma in patients with cirrhosis: value of dual-phase helical CT. AJR 2004, 182(4):1011-1017.
20. Balci NC, Semelka RC Contrast agents for MR imaging of the liver. Radiol Clin North Am 2005, 43(5):887-898. [viii].
21. Gandhi SN, Brown MA, Wong JG, Aguirre DA, Sirlin CB MR contrast agents for liver imaging: what, when, how. Radiographics 2006, 26(6):1621-1636.
22. Willatt JM, Hussain HK, Adusumilli S, Marrero JA MR Imaging of hepatocellular carcinoma in the cirrhotic liver: challenges and controversies. Radiology 2008, 247(2):311-330.
23. Kim MJ, Kim JH, Chung JJ, Park MS, Lim JS, Oh YT Focal hepatic lesions: detection and characterization with combination gadolinium- and superparamagnetic iron oxide-enhanced MR imaging. Radiology 2003, 228(3):719-726.
24. Kim YK, Kim CS, Lee YH, Kwak HS, Lee JM Comparison of superparamagnetic iron oxide-enhanced and gadobenate dimeglumine-enhanced dynamic MRI for detection of small hepatocellular carcinomas. AJR 2004, 182(5):1217-1223.
25. Mazhar SM, Shiehmorteza M, Kohl CA, Middleton MS, Sirlin CB Nephrogenic systemic fibrosis in liver disease: a systematic review. J Magn Reson Imaging 2009, 30(6):1313-1322.
26. Ware DE, Huda W, Mergo PJ, Litwiller AL Radiation effective doses to patients undergoing abdominal CT examinations. Radiology 1999, 210(3):645-650.