Production of interferon α and β, pro-inflammatory cytokines and the expression of suppressor of cytokine signaling (SOCS) in obese subjects infected with influenza A/H1N1

Clinical Nutrition

Volumn 33, Issue 5, 2014, Pages 922-926

  Terán Cabanillas, Elí ^a   Montalvo Corral, Maricela ^a   Silva Campa, Erika ^a   Caire Juvera, Graciela ^a   Moya Camarena, Silvia Y ^a   Hernández, Jesús ^a  

^a CENTRO DE INVESTIGACIÓN EN ALIMENTACIÓN Y DESARROLLO   (Mexico)

Author keywords

IFN; Influenza; Obesity; SOCS3; TLR

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; SOCS1 PROTEIN, HUMAN; SOCS3 PROTEIN, HUMAN; SUPPRESSOR OF CYTOKINE SIGNALING; TLR3 PROTEIN, HUMAN; TLR7 PROTEIN, HUMAN; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 7;

BLOOD; COMPLICATION; CROSS-SECTIONAL STUDY; GENETICS; HUMAN; INFLUENZA; INFLUENZA A VIRUS (H1N1); METABOLISM; MONONUCLEAR CELL; OBESITY; REAL TIME POLYMERASE CHAIN REACTION; VIROLOGY;

CROSS-SECTIONAL STUDIES; HUMANS; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA, HUMAN; INTERFERON-ALPHA; INTERFERON-BETA; LEUKOCYTES, MONONUCLEAR; NF-KAPPA B; OBESITY; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; TOLL-LIKE RECEPTOR 3; TOLL-LIKE RECEPTOR 7;

EID: 84906046196     PISSN: 02615614     EISSN: 15321983     Source Type: Journal    
DOI: 10.1016/j.clnu.2013.10.011     Document Type: Article

References (8)

1. Louie J.K., Acosta M., Samuel M.C., Schechter R., Vugia D.J., Harriman K., et al. A novel risk factor for a novel virus: obesity and 2009 pandemic influenza A (H1N1). Clin Infect Dis 2011, 52:301-312.
2. Smith A.G., Sheridan P.A., Harp J.B., Beck M.A. Diet-induced obese mice have increased mortality and altered immune responses when infected with influenza virus. J Nutr 2007, 137:1236-1243.
3. Pothlichet J., Chignard M., Si-Tahar M. Cutting edge: innate immune response triggered by influenza A virus is negatively regulated by SOCS1 and SOCS3 through a RIG-I/IFNAR1-dependent pathway. J Immunol 2008, 180:2034-2038.
4. Pauli E.-K., Schmolke M., Wolff T., Viemann D., Roth J., Bode J.G., et al. Influenza A virus inhibits type I IFN signaling via NF-κB-dependent induction of SOCS-3 expression. PLoS Pathog 2008, 4:e1000196.
5. Teran-Cabanillas E., Montalvo-Corral M., Caire-Juvera G., Moya-Camarena S.Y., Hernández J. Decreased interferon-α and interferon-β production in obesity and expression of suppressor of cytokine signaling. Nutrition 2013, 29:207-212.
6. Walsh M., Jonsson J., Richardson M.M., Lipka G., Purdie D., Clouston A., et al. Non-response to antiviral therapy is associated with obesity and increased hepatic expression of suppressor of cytokine signalling 3 (SOCS-3) in patients with chronic hepatitis C, viral genotype 1. Gut 2006, 55:529-535.
7. Guillot L., Le Goffic R., Bloch S., Escriou N., Akira S., Chignard M., et al. Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus. J Biol Chem 2005, 280:5571-5580.
8. Ramírez-Martínez G., Cruz-Lagunas A., Jiménez-Alvarez L., Espinosa E., Ortíz-Quintero B., Santos-Mendoza T., et al. Seasonal and pandemic influenza H1N1 viruses induce differential expression of SOCS-1 and RIG-I genes and cytokine/chemokine production in macrophages. Cytokine 2013, 62:151-159.