Resistance profiles of coagulase-negative staphylococci contaminating blood cultures predict pathogen resistance and patient mortality

Journal of Antimicrobial Chemotherapy

Volumn 69, Issue 9, 2014, Pages 2541-2546

  Obolski, Uri ^a   Alon, Danny ^a   Hadany, Lilach ^a   Stein, Gideon Y ^a  

^a TEL AVIV UNIVERSITY   (Israel)

Author keywords

Antibiotic resistance; CoNS; Contaminants

Indexed keywords

AMIKACIN; AMOXICILLIN PLUS CLAVULANIC ACID; AMPICILLIN; AZTREONAM; CEFAZOLIN; CEFEPIME; CEFOTAXIME; CEFTAZIDIME; CEFTRIAXONE; CEFUROXIME; CHLORAMPHENICOL; CIPROFLOXACIN; CLINDAMYCIN; COLISTIN; ERTAPENEM; ERYTHROMYCIN; FUSIDIC ACID; GENTAMICIN; IMIPENEM; LEVOFLOXACIN; LINEZOLID; MEROPENEM; METICILLIN; METRONIDAZOLE; OXACILLIN; PENICILLIN G; PIPERACILLIN; PIPERACILLIN PLUS TAZOBACTAM; SULTAMICILLIN; UNINDEXED DRUG; ANTIINFECTIVE AGENT; COAGULASE;

AGE DISTRIBUTION; AGED; ANTIBIOTIC RESISTANCE; ANTIBIOTIC THERAPY; ARTICLE; ASSOCIATION; BACTERIUM CONTAMINATION; BACTERIUM ISOLATION; BLOOD CULTURE; CHRONIC OBSTRUCTIVE LUNG DISEASE; COAGULASE NEGATIVE STAPHYLOCOCCUS; DECUBITUS; DEMENTIA; DEMOGRAPHY; DRUG EXPOSURE; FEMALE; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HOSPITALIZATION; HUMAN; ISRAEL; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MORTALITY; RETROSPECTIVE STUDY; BACTEREMIA; BLOOD; DRUG EFFECTS; ENZYMOLOGY; ISOLATION AND PURIFICATION; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; MIDDLE AGED; SECRETION (PROCESS); STAPHYLOCOCCUS; SURVIVAL; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ANTI-BACTERIAL AGENTS; BACTEREMIA; BLOOD; COAGULASE; DRUG RESISTANCE, BACTERIAL; FEMALE; HUMANS; ISRAEL; MALE; MICROBIAL SENSITIVITY TESTS; MIDDLE AGED; RETROSPECTIVE STUDIES; STAPHYLOCOCCUS; SURVIVAL ANALYSIS;

EID: 84905982016     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dku156     Document Type: Article

References (27)

1. Maragakis LL, Perencevich EN, Cosgrove SE. Clinical and economic burden of antimicrobial resistance. Expert Rev Anti Infect Ther 2008; 6: 751-63.
2. Carmeli Y, Troillet N, Karchmer AWet al. Health and economic outcomes of antibiotic resistance in Pseudomonas aeruginosa. Arch Intern Med 1999; 159: 1127-32.
3. Cosgrove SE, Qi Y, Kaye KS et al. The impact of methicillin resistance in Staphylococcus aureus bacteremia on patient outcomes: mortality, length of stay, and hospital charges. Infect Control Hosp Epidemiol 2005; 26: 166-74.
4. Septimus E. Clinician Guide. http://www.cdc.gov/getsmart/healthcare/ learn-from-others/resources/clinician-guide.html (13 December 2013, date last accessed).
5. Dellinger RP, Levy MM, Rhodes A et al. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med 2013; 39: 165-228.
6. Berild D, Mohseni A, Diep LM et al. Adjustment of antibiotic treatment according to the results of blood cultures leads to decreased antibiotic use and costs. J Antimicrob Chemother 2006; 57: 326-30.
7. Souvenir D, Anderson DE, Palpant S et al. Blood cultures positive for coagulase-negative staphylococci: antisepsis, pseudobacteremia, and therapy of patients. J Clin Microbiol 1998; 36: 1923-6.
8. Fridkin SK, Welbel SF, Weinstein RA. Magnitude and prevention of nosocomial infections in the intensive care unit. Infect Dis Clin North Am 1997; 11: 479-96.
9. Diekema D, Pfaller M, Jones R. Age-related trends in pathogen frequency and antimicrobial susceptibility of bloodstream isolates in North America: SENTRY Antimicrobial Surveillance Program, 1997-2000. Int J Antimicrob Agents 2002; 20: 412-8.
10. Edmond MB, Wallace SE, McClish DK et al. Nosocomial bloodstream infections in United States hospitals: a three-year analysis. Clin Infect Dis 1999; 29: 239-44.
11. N'Guyen Y, Baumard S, Vernet-Garnier V et al. Coagulase-negative Staphylococcus bacteraemia accounts for one third of Staphylococcus bacteraemia in a French university hospital. Scand J Infect Dis 2012; 44: 79-85.
12. Fajardo Olivares M, Hidalgo Orozco R, Rodríguez Garrido S et al. Activity of vancomycin, ciprofloxacin, daptomycin, and linezolid against coagulase-negative staphylococci bacteremia. Rev Esp Quimioter 2011; 24: 74-8.
13. Ahlstrand E, Persson L, Tidefelt U et al. Alteration of the colonization pattern of coagulase-negative staphylococci in patients undergoing treatment for hematological malignancy. Eur J Clin Microbiol Infect Dis 2012; 31: 1679-87.
14. Knauer A, Fladerer P, Strempfl C et al. Effect of hospitalization and antimicrobial therapy on antimicrobial resistance of colonizing Staphylococcus epidermidis. Wien Klin Wochenschr 2004; 116: 489-94.
15. Archer GL. Alteration of cutaneous staphylococcal flora as a consequence of antimicrobial prophylaxis. Rev Infect Dis 1991; 13 Suppl 10: S805-S809.
16. Blum-Menezes D, Bratfich O, Padoveze M et al. Hospital strain colonization by Staphylococcus epidermidis. Braz J Med Biol Res 2009; 42: 294-8.
17. Kotilainen P, Nikoskelainen J, Huovinen P. Emergence of ciprofloxacinresistant coagulase-negative staphylococcal skin flora in immunocompromised patients receiving ciprofloxacin. J Infect Dis 1990; 161: 41-4.
18. Beekmann SE, Diekema DJ, Doern GV. Determining the clinical significance of coagulase-negative staphylococci isolated from blood cultures. Infect Control Hosp Epidemiol 2005; 26: 559-66.
19. Al Wohoush I, Rivera J, Cairo J et al. Comparing clinical and microbiological methods for the diagnosis of true bacteraemia among patients with multiple blood cultures positive for coagulase-negative staphylococci. Clin Microbiol Infect 2011; 17: 569-71.
20. Burnham KP, Anderson DR. Model Selection and Multimodel Inference: A Practical Information-Theoretic Approach. New York: Springer, 2002.
21. Grice EA, Kong HH, Conlan S et al. Topographical and temporal diversity of the human skin microbiome. Science 2009; 324: 1190-2.
22. Ochman H, Lawrence JG, Groisman EA. Lateral gene transfer and the nature of bacterial innovation. Nature 2000; 405: 299-304.
23. Courvalin P. Transfer of antibiotic resistance genes between grampositive and gram-negative bacteria. Antimicrob Agents Chemother 1994; 38: 1447.
24. Otto M. Staphylococcus epidermidis-the 'accidental' pathogen. Nat Rev Microbiol 2009; 7: 555-67.
25. Palmer AC, Kishony R. Understanding, predicting and manipulating the genotypic evolution of antibiotic resistance. Nat Rev Genet 2013; 14: 243-8.
26. Klingenberg C, Rønnestad A, Anderson A et al. Persistent strains of coagulase-negative staphylococci in a neonatal intensive care unit: virulence factors and invasiveness. Clin Microbiol Infect 2007; 13: 1100-11.
27. Villari P, Sarnataro C, Iacuzio L. Molecular epidemiology of Staphylococcus epidermidis in a neonatal intensive care unit over a three-year period. J Clin Microbiol 2000; 38: 1740-6.