Structure-function analysis of mouse Sry reveals dual essential roles of the C-terminal polyglutamine tract in sex determination

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 32, 2014, Pages 11768-11773

  Zhao, Liang ^a   Ng, Ee Ting ^a   Davidson, Tara Lynne ^a   Longmuss, Enya ^a   Urschitz, Johann ^b   Elston, Marlee ^b   Moisyadi, Stefan ^b   Bowles, Josephine ^a   Koopman, Peter ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b UNIVERSITY OF HAWAII   (United States)

Author keywords

Sex development; TESCO; Testis; Y chromosome

Indexed keywords

POLYGLUTAMINE; TESTIS DETERMINING FACTOR; TRANSCRIPTION FACTOR SOX9;

ANIMAL EXPERIMENT; ARTICLE; CARBOXY TERMINAL SEQUENCE; HIGH MOBILITY GROUP BOX DOMAIN; IN VITRO STUDY; MOUSE; MOUSE EMBRYO; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN STABILITY; SEX DETERMINATION; SEX TRANSFORMATION; SRY GENE; TRANSACTIVATION; TRANSCRIPTION INITIATION;

SEX DEVELOPMENT; TESCO; TESTIS; Y CHROMOSOME;

ANIMALS; EVOLUTION, MOLECULAR; FEMALE; GENES, REPORTER; GENES, SRY; MALE; MICE; MICE, TRANSGENIC; MUTAGENESIS; PEPTIDE FRAGMENTS; PEPTIDES; PREGNANCY; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN DENATURATION; PROTEIN STABILITY; PROTEIN STRUCTURE, TERTIARY; SEQUENCE DELETION; SEX DETERMINATION PROCESSES; SEX-DETERMINING REGION Y PROTEIN; SOX9 TRANSCRIPTION FACTOR; TRANSCRIPTIONAL ACTIVATION;

EID: 84905971345     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1400666111     Document Type: Article

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