Neglected side effects after radical prostatectomy: A systematic review

Journal of Sexual Medicine

Volumn 11, Issue 2, 2014, Pages 374-385

  Frey, Anders Ullmann ^a   Sønksen, Jens ^a   Fode, Mikkel ^a  

^a GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Climacturia; Dysorgasmia; Orgasm Associated Pain; Penile Length; Radical Prostatectomy

Indexed keywords

ALTERED PERCEPTION OF ORGASM; ARTICLE; ERECTILE DYSFUNCTION; HIGH RISK PATIENT; HUMAN; INCIDENCE; MALE SEXUAL DYSFUNCTION; ORGASM ASSOCIATED INCONTINENCE; ORGASM ASSOCIATED PAIN; ORGASM DISORDER; PENILE DEFORMITY; PENILE SHORTENING; PENIS DISEASE; PENIS ERECTION; PRIORITY JOURNAL; PROSTATECTOMY; SEMINAL VESICLE; SURGICAL RISK; SYSTEMATIC REVIEW; TRANSURETHRAL RESECTION; URINARY INCONTINENCE IN RELATION TO SEXUAL STIMULATION; URINE INCONTINENCE; CLIMACTURIA; DYSORGASMIA; MALE; ORGASM; ORGASM-ASSOCIATED PAIN; PENILE LENGTH; PROSTATE TUMOR; PSYCHOSEXUAL DISORDER; REVIEW; SEXUAL BEHAVIOR; STRESS INCONTINENCE;

CLIMACTURIA; DYSORGASMIA; ORGASM-ASSOCIATED PAIN; PENILE LENGTH; RADICAL PROSTATECTOMY;

ERECTILE DYSFUNCTION; HUMANS; MALE; ORGASM; PENILE DISEASES; PENILE ERECTION; PROSTATECTOMY; PROSTATIC NEOPLASMS; SEXUAL BEHAVIOR; SEXUAL DYSFUNCTIONS, PSYCHOLOGICAL; URINARY INCONTINENCE, STRESS;

EID: 84905965815     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/jsm.12403     Document Type: Review

References (50)

1. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010;127:2893-2917.
2. Bill-Axelson A, Holmberg L, Ruutu M, Garmo H, Stark JR, Busch C, Nordling S, Haggman M, Andersson SO, Bratell S, Spangberg A, Palmgren J, Steineck G, Adami HO, Johansson JE. Radical prostatectomy versus watchful waiting in early prostate cancer. N Engl J Med 2011;364:1708-1717.
3. Tal R, Alphs HH, Krebs P, Nelson CJ, Mulhall JP. Erectile function recovery rate after radical prostatectomy: A meta-analysis. J Sex Med 2009;6:2538-2546.
4. Ficarra V, Novara G, Rosen RC, Artibani W, Carroll PR, Costello A, Menon M, Montorsi F, Patel VR, Stolzenburg JU, Van der Poel H, Wilson TG, Zattoni F, Mottrie A. Systematic review and meta-analysis of studies reporting urinary continence recovery after robot-assisted radical prostatectomy. Eur Urol 2012;62:405-417.
5. Salonia A, Burnett AL, Graefen M, Hatzimouratidis K, Montorsi F, Mulhall JP, Stief C. Prevention and management of postprostatectomy sexual dysfunctions part 2: Recovery and preservation of erectile function, sexual desire, and orgasmic function. Eur Urol 2012;62:273-286.
6. Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gotzsche PC, Ioannidis JP, Clarke M, Devereaux PJ, Kleijnen J, Moher D. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: Explanation and elaboration. BMJ 2009;339:b2700.
7. Koeman M, van Driel MF, Schultz WC, Mensink HJ. Orgasm after radical prostatectomy. Br J Urol 1996;77:861-864.
8. Barnas JL, Pierpaoli S, Ladd P, Valenzuela R, Aviv N, Parker M, Waters WB, Flanigan RC, Mulhall JP. The prevalence and nature of orgasmic dysfunction after radical prostatectomy. BJU Int 2004;94:603-605.
9. Lee J, Hersey K, Lee CT, Fleshner N. Climacturia following radical prostatectomy: Prevalence and risk factors. J Urol 2006;176(6 Pt 1):2562-2565.
10. Choi JM, Nelson CJ, Stasi J, Mulhall JP. Orgasm associated incontinence (climacturia) following radical pelvic surgery: Rates of occurrence and predictors. J Urol 2007;177:2223-2226.
11. Guay A, Seftel AD. Sexual foreplay incontinence in men with erectile dysfunction after radical prostatectomy: A clinical observation. Int J Impot Res 2008;20:199-201.
12. Mitchell SA, Jain RK, Laze J, Lepor H. Post-prostatectomy incontinence during sexual activity: A single center prevalence study. J Urol 2011;186:982-985.
13. Nilsson AE, Carlsson S, Johansson E, Jonsson MN, Adding C, Nyberg T, Steineck G, Wiklund NP. Orgasm-associated urinary incontinence and sexual life after radical prostatectomy. J Sex Med 2011;8:2632-2639.
14. Messaoudi R, Menard J, Ripert T, Parquet H, Staerman F. Erectile dysfunction and sexual health after radical prostatectomy: Impact of sexual motivation. Int J Impot Res 2011;23:81-86.
15. Manassero F, Di PG, Paperini D, Mogorovich A, Pistolesi D, Valent F, Selli C. Orgasm-Associated incontinence (climacturia) after bladder neck-sparing radical prostatectomy: Clinical and video-urodynamic evaluation. J Sex Med 2012;9:2150-2156.
16. Mehta A, Deveci S, Mulhall JP. Efficacy of a penile variable tension loop for improving climacturia after radical prostatectomy. BJU Int 2013;111:500-504.
17. Jain R, Mitchell S, Laze J, Lepor H. The effect of surgical intervention for stress urinary incontinence (UI) on post-prostatectomy UI during sexual activity. BJU Int 2012;109:1208-1212.
18. Helgason AR, Adolfsson J, Dickman P, Fredrikson M, Arver S, Steineck G. Waning sexual function-the most important disease-specific distress for patients with prostate cancer. Br J Cancer 1996;73:1417-1421.
19. Hollenbeck BK, Dunn RL, Wei JT, Montie JE, Sanda MG. Determinants of long-term sexual health outcome after radical prostatectomy measured by a validated instrument. J Urol 2003;169:1453-1457.
20. Dubbelman YD, Wildhagen MF, Dohle GR. Penile vascular evaluation and sexual function before and after radical retropubic prostatectomy: 5-year follow-up. Int J Androl 2008;31:483-489.
21. Dubbelman Y, Wildhagen M, Schroder F, Bangma C, Dohle G. Orgasmic dysfunction after open radical prostatectomy: Clinical correlates and prognostic factors. J Sex Med 2010;7:1216-1223.
22. Salonia A, Gallina A, Briganti A, Colombo R, Bertini R, Da Pozzo LF, Zanni G, Sacca A, Rocchini L, Guazzoni G, Rigatti P, Montorsi F. Postoperative orgasmic function increases over time in patients undergoing nerve-sparing radical prostatectomy. J Sex Med 2010;7(1 Pt 1):149-155.
23. Le JD, Cooperberg MR, Sadetsky N, Hittelman AB, Meng MV, Cowan JE, Latini DM, Carroll PR. Changes in specific domains of sexual function and sexual bother after radical prostatectomy. BJU Int 2010;106:1022-1029.
24. Tewari A, Grover S, Sooriakumaran P, Srivastava A, Rao S, Gupta A, Gray R, Leung R, Paduch DA. Nerve sparing can preserve orgasmic function in most men after robotic-assisted laparoscopic radical prostatectomy. BJU Int 2012;109:596-602.
25. Matsushita K, Tal R, Mulhall JP. The evolution of orgasmic pain (dysorgasmia) following radical prostatectomy. J Sex Med 2012;9:1454-1458.
26. Mah K, Binik YM. The nature of human orgasm: A critical review of major trends. Clin Psychol Rev 2001;21:823-856.
27. Nehra A, Grantmyre J, Nadel A, Thibonnier M, Brock G. Vardenafil improved patient satisfaction with erectile hardness, orgasmic function and sexual experience in men with erectile dysfunction following nerve sparing radical prostatectomy. J Urol 2005;173:2067-2071.
28. Barnas J, Parker M, Guhring P, Mulhall JP. The utility of tamsulosin in the management of orgasm-associated pain: A pilot analysis. Eur Urol 2005;47:361-365.
29. Mogorovich A, Nilsson AE, Tyritzis SI, Carlsson S, Jonsson M, Haendler L, Nyberg T, Steineck G, Wiklund NP. Radical prostatectomy, sparing of the seminal vesicles, and painful orgasm. J Sex Med 2013;10:1417-1423.
30. Hisasue S, Furuya R, Itoh N, Kobayashi K, Furuya S, Tsukamoto T. Ejaculatory disorder caused by alpha-1 adrenoceptor antagonists is not retrograde ejaculation but a loss of seminal emission. Int J Urol 2006;13:1311-1316.
31. Fraiman MC, Lepor H, McCullough AR. Changes in penile morphometrics in men with erectile dysfunction after nerve-sparing radical retropubic prostatectomy. Mol Urol 1999;3:109-115.
32. Munding MD, Wessells HB, Dalkin BL. Pilot study of changes in stretched penile length 3 months after radical retropubic prostatectomy. Urology 2001;58:567-569.
33. Savoie M, Kim SS, Soloway MS. A prospective study measuring penile length in men treated with radical prostatectomy for prostate cancer. J Urol 2003;169:1462-1464.
34. Gontero P, Galzerano M, Bartoletti R, Magnani C, Tizzani A, Frea B, Mondaini N. New insights into the pathogenesis of penile shortening after radical prostatectomy and the role of postoperative sexual function. J Urol 2007;178:602-607.
35. Briganti A, Fabbri F, Salonia A, Gallina A, Chun FK, Deho F, Zanni G, Suardi N, Karakiewicz PI, Rigatti P, Montorsi F. Preserved postoperative penile size correlates well with maintained erectile function after bilateral nerve-sparing radical retropubic prostatectomy. Eur Urol 2007;52:702-707.
36. Engel JD, Sutherland DE, Williams SB, Wagner KR. Changes in penile length after robot-assisted laparoscopic radical prostatectomy. J Endourol 2011;25:65-69.
37. Carlsson S, Nilsson AE, Johansson E, Nyberg T, Akre O, Steineck G. Self-perceived penile shortening after radical prostatectomy. Int J Impot Res 2012;24:179-184.
38. Vasconcelos JS, Figueiredo RT, Nascimento FL, Damiao R, da Silva EA. The natural history of penile length after radical prostatectomy: A long-term prospective study. Urology 2012;80:1293-1296.
39. Tal R, Heck M, Teloken P, Siegrist T, Nelson CJ, Mulhall JP. Peyronie's disease following radical prostatectomy: Incidence and predictors. J Sex Med 2010;7:1254-1261.
40. Ciancio SJ, Kim ED. Penile fibrotic changes after radical retropubic prostatectomy. BJU Int 2000;85:101-106.
41. Benson JS, Abern MR, Levine LA. Penile shortening after radical prostatectomy and Peyronie's surgery. Curr Urol Rep 2009;10:468-474.
42. Kim N, Vardi Y, Padma-Nathan H, Daley J, Goldstein I, Saenz dT I. Oxygen tension regulates the nitric oxide pathway. Physiological role in penile erection. J Clin Invest 1993;91:437-442.
43. Iacono F, Giannella R, Somma P, Manno G, Fusco F, Mirone V. Histological alterations in cavernous tissue after radical prostatectomy. J Urol 2005;173:1673-1676.
44. Schwartz EJ, Wong P, Graydon RJ. Sildenafil preserves intracorporeal smooth muscle after radical retropubic prostatectomy. J Urol 2004;171(2 Pt 1):771-774.
45. Iacono F, Prezioso D, Somma P, Chierchia S, Galasso R, Micheli P. Histopathologically proven prevention of post-prostatectomy cavernosal fibrosis with sildenafil. Urol Int 2008;80:249-252.
46. Aydogdu O, Gokce MI, Burgu B, Baltaci S, Yaman O. Tadalafil rehabilitation therapy preserves penile size after bilateral nerve sparing radical retropubic prostatectomy. Int Braz J Urol 2011;37:336-344.
47. Raina R, Agarwal A, Ausmundson S, Lakin M, Nandipati KC, Montague DK, Mansour D, Zippe CD. Early use of vacuum constriction device following radical prostatectomy facilitates early sexual activity and potentially earlier return of erectile function. Int J Impot Res 2006;18:77-81.
48. Dalkin BL, Christopher BA. Preservation of penile length after radical prostatectomy: Early intervention with a vacuum erection device. Int J Impot Res 2007;19:501-504.
49. Kohler TS, Pedro R, Hendlin K, Utz W, Ugarte R, Reddy P, Makhlouf A, Ryndin I, Canales BK, Weiland D, Nakib N, Ramani A, Anderson JK, Monga M. A pilot study on the early use of the vacuum erection device after radical retropubic prostatectomy. BJU Int 2007;100:858-862.
50. Perugia G, Liberti M, Vicini P, Colistro F, Gentile V. Use of local hyperthermia as prophylaxis of fibrosis and modification in penile length following radical retropubic prostatectomy. Int J Hyperthermia 2005;21:359-365.