Long-standing type 1 diabetes: Patients with adult-onset develop celiac-specific immunoreactivity more frequently than patients with childhood-onset diabetes, in a disease duration-dependent manner

Acta Diabetologica

Volumn 51, Issue 4, 2014, Pages 675-678

  Tiberti, Claudio ^a   Panimolle, Francesca ^a   Bonamico, Margherita ^a   Filardi, Tiziana ^a   Pallotta, Lucia ^a   Nenna, Raffaella ^a   Pontone, Stefano ^a   Dotta, Francesco ^b   Pugliese, Giuseppe ^a   Lenzi, Andrea ^a   Balducci, Stefano ^a   Morano, Susanna ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF SIENA   (Italy)

Author keywords

Adult onset autoimmune diabetes; Celiac autoimmunity; Celiac disease; Childhood onset autoimmune diabetes; Deamidated gliadin antibodies; Long standing type 1 diabetes; Transglutaminase antibodies

Indexed keywords

AUTOANTIBODY; GUANINE NUCLEOTIDE BINDING PROTEIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE 2;

ADOLESCENT; ADULT; BLOOD; CELIAC DISEASE; CHILD; COHORT ANALYSIS; COMPARATIVE STUDY; COMPLICATION; FEMALE; HUMAN; IMMUNOLOGY; INSULIN DEPENDENT DIABETES MELLITUS; MALE; MIDDLE AGED; ONSET AGE; PRESCHOOL CHILD; YOUNG ADULT;

ADOLESCENT; ADULT; AGE OF ONSET; AUTOANTIBODIES; CELIAC DISEASE; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; DIABETES MELLITUS, TYPE 1; FEMALE; GTP-BINDING PROTEINS; HUMANS; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; MALE; MIDDLE AGED; TRANSGLUTAMINASES; YOUNG ADULT;

EID: 84905914446     PISSN: 09405429     EISSN: 14325233     Source Type: Journal    
DOI: 10.1007/s00592-013-0536-0     Document Type: Article

References (5)

1. Cerutti F, Bruno G, Chiarelli F, Lorini R, Meschi F, Sacchetti C, The Diabetes Study Group of Italian Society of Pediatric Endocrinology and Diabetology (2004) Younger age at onset and sex predict celiac disease in children and adolescents with type 1 diabetes. Diabetes Care 27:1294-1298 (Pubitemid 38679973)
2. Tiberti C, Panimolle F, Bonamico M, Shashaj B, Filardi T, Lucantoni F, Nenna R, Costantino F, Lenzi A, Morano S (2012) IgA anti-transglutaminase autoantibodies at type 1 diabetes onset are less frequent in adult patients and are associated to a general celiac-specific lower immune response in comparison with non-diabetic celiac patients at diagnosis. Diabetes Care 35:1-3
3. Li M, Yu L, Tiberti C, Bonamico M, Taki I, Miao D, Murray JA, Rewers MJ, Hoffenberg EJ, Agardh D, Mueller P, Stern M, Bonifacio E, Liu E (2009) A report on the international transglutaminase autoantibody workshop for celiac disease. Am J Gastroenterol 104:154-163
4. Sjöberg K, Eriksson KF, Bredberg A, Wassmuth R, Eriksson S (1998) Screening for celiac disease in adult insulin-dependent diabetes mellitus. J Int Med 243:133-140 (Pubitemid 28156661)
5. Leeds JS, Hopper AD, Hadjivassiliou M, Tesfaye S, Sanders DS (2011) High prevalence of microvascular complications in adults with type 1 diabetes and newly diagnosed celiac disease. Diabetes Care 34:2158-2163