Expression patterning reveals retinal inflammation as a minor factor in experimental retinopathy of ZDF rats

Acta Diabetologica

Volumn 51, Issue 4, 2014, Pages 553-558

  Wohlfart, Paulus ^a   Lin, Jihong ^b   Dietrich, Nadine ^b   Kannt, Aimo ^a   Elvert, Ralf ^a   Herling, Andreas W ^a   Hammes, Hans Peter ^b  

^a Diabetes Division and Translational Medicine   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Adhesion; Diabetic retinopathy; Growth factors; Inflammation; Preclinical model; Zucker diabetic fatty rats

Indexed keywords

FIBROBLAST GROWTH FACTOR 2; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN A;

ANIMAL; COMPLICATION; DIABETIC RETINOPATHY; DISEASE MODEL; GENETICS; HUMAN; IMMUNOLOGY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; RAT; RETINA; ZUCKER RAT;

ANIMALS; DIABETES MELLITUS, TYPE 2; DIABETIC RETINOPATHY; DISEASE MODELS, ANIMAL; FIBROBLAST GROWTH FACTOR 2; HUMANS; INTERLEUKIN-6; MALE; RATS; RATS, ZUCKER; RETINA; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84905905094     PISSN: 09405429     EISSN: 14325233     Source Type: Journal    
DOI: 10.1007/s00592-013-0550-2     Document Type: Article

References (18)

1. Hirsch IB, Brownlee M (2010) Beyond hemoglobin A1c - Need for additional markers of risk for diabetic microvascular complications. JAMA 303:2291-2292
2. Danis RP, Yang Y (1993) Microvascular retinopathy in the Zucker diabetic fatty rat. Invest Ophthalmol Vis Sci 34:2367-2371 (Pubitemid 23191268)
3. Yang YS, Danis RP, Peterson RG, Dolan PL, Wu YQ (2000) Acarbose partially inhibits microvascular retinopathy in the Zucker diabetic fatty rat (ZDF/Gmi-fa). J Ocul Pharmacol Ther 16:471-479
4. Behl Y, Krothapalli P, Desta T, DiPiazza A, Roy S, Graves DT (2008) Diabetes-enhanced tumor necrosis factor-alpha production promotes apoptosis and the loss of retinal microvascular cells in type 1 and type 2 models of diabetic retinopathy. Am J Pathol 172:1411-1418 (Pubitemid 351671553)
5. Behl Y, Krothapalli P, Desta T, Roy S, Graves DT (2009) FOXO1 plays an important role in enhanced microvascular cell apoptosis and microvascular cell loss in type 1 and type 2 diabetic rats. Diabetes 58:917-925
6. Mima A, Qi W, Hiraoka-Yamomoto J et al (2012) Retinal not systemic oxidative and inflammatory stress correlated with VEGF expression in rodent models of insulin resistance and diabetes. Invest Ophthalmol Vis Sci 53:8424-8432
7. Miranville A, Herling AW, Biemer-Daub G, Voss MD (2012) Differential adipose tissue inflammatory state in obese nondiabetic Zucker fatty rats compared to obese diabetic zucker diabetic fatty rats. Horm Metab Res 44:273-278
8. Dietrich N, Hammes HP (2012) Retinal digest preparation: a method to study diabetic retinopathy. Methods Mol Biol 933:291-302
9. Pfaffl MW, Tichopad A, Prgomet C, Neuvians TP (2004) Determination of stable housekeeping genes, differentially regulated target genes and sample integrity: BestKeeper - Excelbased tool using pair-wise correlations. Biotechnol Lett 26:509-515 (Pubitemid 38448421)
10. Hammes HP, Martin S, Federlin K, Geisen K, Brownlee M (1991) Aminoguanidine treatment inhibits the development of experimental diabetic retinopathy. Proc Natl Acad Sci USA 88:11555-11558 (Pubitemid 21916080)
11. Noda K, Nakao S, Ishida S, Ishibashi T (2012) Leukocyte adhesion molecules in diabetic retinopathy. J Ophthalmol 2012:279037
12. Li G, Tang J, Du Y, Lee CA, Kern TS (2011) Beneficial effects of a novel RAGE inhibitor on early diabetic retinopathy and tactile allodynia. Mol Vis 17:3156-3165
13. Wang Q, Gorbey S, Pfister F et al (2011) Long-term treatment with suberythropoietic Epo is vaso- and neuroprotective in experimental diabetic retinopathy. Cell Physiol Biochem 27:769-782
14. Ozaki H, Okamoto N, Ortega S et al (1998) Basic fibroblast growth factor is neither necessary nor sufficient for the development of retinal neovascularization. Am J Pathol 153:757-765 (Pubitemid 28419030)
15. Hanneken A, de Juan E, Lutty GA Jr, Fox GM, Schiffer S, Hjelmeland LM (1991) Altered distribution of basic fibroblast growth factor in diabetic retinopathy. Arch Ophthalmol 109:1005-1011
16. Kowalczuk L, Touchard E, Omri S et al (2011) Placental growth factor contributes to micro-vascular abnormalization and bloodretinal barrier breakdown in diabetic retinopathy. PLoS One 6:e17462
17. Giacco F, Brownlee M (2010) Oxidative stress and diabetic complications. Circ Res 107:1058-1070
18. Pfister F, Feng Y, vom Hagen F et al (2008) Pericyte migration: a novel mechanism of pericyte loss in experimental diabetic retinopathy. Diabetes 57:2495-2502