Interferon regulatory factor 5 genetic variants are associated with cardiovascular disease in patients with rheumatoid arthritis

Arthritis Research and Therapy

Volumn 16, Issue 4, 2014, Pages

  García Bermúdez, Mercedes ^a   López Mejías, Raquel ^b   Genre, Fernanda ^b   Castañeda, Santos ^c   Llorca, Javier ^d   González Juanatey, Carlos ^e   Corrales, Alfonso ^b   Ubilla, Begoña ^b   Miranda Filloy, José A ^e   Pina, Trinitario ^b   Gómez Vaquero, Carmen ^f   Rodríguez Rodríguez, Luis ^g   Fernández Gutiérrez, Benjamín ^g   Balsa, Alejandro ^h   Pascual Salcedo, Dora ^h   López Longo, Francisco J ⁱ   Carreira, Patricia ^j   Blanco, Ricardo ^b   Martín, Javier ^a   González Gay, Miguel A ^b,k  

^a INSTITUTO DE PARASITOLOGÍA Y BIOMEDICINA LÓPEZ NEYRA   (Spain)

^b Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases   (Spain)

^c HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

^d UNIVERSITY OF CANTABRIA   (Spain)

^e Hospital Lucus Augusti   (Spain)

^f HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

^g HOSPITAL CLÍNICO SAN CARLOS   (Spain)

^h HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

ⁱ HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^j HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

^k UNIVERSITY OF THE WITWATERSRAND   (South Africa)

more..

Author keywords

[No Author keywords available]

Indexed keywords

INTERFERON REGULATORY FACTOR 5; INTERFERON REGULATORY FACTOR; IRF5 PROTEIN, HUMAN;

ADULT; ARTICLE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CONTROLLED STUDY; DISEASE ASSOCIATION; DYSLIPIDEMIA; GENE LOCUS; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING; COMPLICATION; FEMALE; GENETIC PREDISPOSITION; GENETICS; MIDDLE AGED; RISK FACTOR;

ARTHRITIS, RHEUMATOID; CARDIOVASCULAR DISEASES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HAPLOTYPES; HUMANS; INTERFERON REGULATORY FACTORS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; REAL-TIME POLYMERASE CHAIN REACTION; RISK FACTORS;

EID: 84905825934     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar4608     Document Type: Article

References (22)

1. Avina-Zubieta JA, Thomas J, Sadatsafavi M, Lehman AJ, Lacaille D. Risk of incident cardiovascular events in patients with rheumatoid arthritis: a meta-analysis of observational studies. Ann Rheum Dis 2012, 71:1524-1529.
2. Solomon DH, Goodson NJ, Katz JN, Weinblatt ME, Avorn J, Setoguchi S, Canning C, Schneeweiss S. Patterns of cardiovascular risk in rheumatoid arthritis. Ann Rheum Dis 2006, 65:1608-1612.
3. Dessein PH, Norton GR, Woodiwiss AJ, Joffe BI, Wolfe F. Influence of nonclassical cardiovascular risk factors on the accuracy of predicting subclinical atherosclerosis in rheumatoid arthritis. J Rheumatol 2007, 34:943-951.
4. Gonzalez-Gay MA, Gonzalez-Juanatey C, Lopez-Diaz MJ, Pineiro A, Garcia-Porrua C, Miranda-Filloy JA, Ollier WE, Martin J, Llorca J. HLA-DRB1 and persistent chronic inflammation contribute to cardiovascular events and cardiovascular mortality in patients with rheumatoid arthritis. Arthritis Rheum 2007, 57:125-132.
5. Garci´a-Bermu´dez M, Gonza´lez-Juanatey C, Lo´pez-Meji´as R, Teruel M, Corrales A, Miranda-Filloy JA, Castañeda S, Balsa A, Ferna´ndez-Gutierrez B, Gonza´lez-A´lvaro I, Go´mez-Vaquero C, Blanco R, Llorca J, Marti´n J, Gonza´lez-Gay MA. Study of association of CD40-CD154 gene polymorphisms with disease susceptibility and cardiovascular risk in Spanish rheumatoid arthritis patients. PLoS One 2012, 7:e49214.
6. Garci´a-Bermu´dez M, Lo´pez-Meji´as R, Genre F, Castañeda S, Gonza´lez-Juanatey C, Llorca J, Corrales A, Miranda-Filloy JA, Rueda-Gotor J, Go´mez-Vaquero C, Rodri´guez-Rodri´guez L, Ferna´ndez-Gutie´rrez B, Pascual-Salcedo D, Balsa A, Lo´pez-Longo FJ, Carreira P, Blanco R, Gonza´lez-A´lvaro I, Marti´n J, Gonza´lez-Gay MA. SMAD3 rs17228212 gene polymorphism is associated with reduced risk to cerebrovascular accidents and subclinical atherosclerosis in anti-CCP negative Spanish rheumatoid arthritis patients. PLoS One 2013, 8:e77695.
7. Lo´pez-Meji´as R, Garci´a-Bermu´dez M, Gonza´lez-Juanatey C, Castañeda S, Miranda-Filloy JA, Go´mez-Vaquero C, Ferna´ndez-Gutie´rrez B, Balsa A, Pascual-Salcedo D, Blanco R, Gonza´lez-A´lvaro I, Llorca J, Marti´n J, Gonza´lez-Gay MA. NFKB1-94ATTG ins/del polymorphism (rs28362491) is associated with cardiovascular disease in patients with rheumatoid arthritis. Atherosclerosis 2012, 224:426-429.
8. Lo´pez-Meji´as R, Genre F, Garci´a-Bermu´dez M, Corrales A, Gonza´lez-Juanatey C, Llorca J, Miranda-Filloy JA, Rueda-Gotor J, Blanco R, Castañeda S, Marti´n J, Gonza´lez-Gay MA. The ZC3HC1 rs11556924 polymorphism is associated with increased carotid intima-media thickness in patients with rheumatoid arthritis. Arthritis Res Ther 2013, 15:R152.
9. Higgs BW, Liu Z, White B, Zhu W, White WI, Morehouse C, Brohawn P, Kiener PA, Richman L, Fiorentino D, Greenberg SA, Jallal B, Yao Y. Patients with systemic lupus erythematosus, myositis, rheumatoid arthritis and scleroderma share activation of a common type I interferon pathway. Ann Rheum Dis 2011, 70:2029-2036.
10. Schoenemeyer A, Barnes BJ, Mancl ME, Latz E, Goutagny N, Pitha PM, Fitzgerald KA, Golenbock DT. The interferon regulatory factor, IRF5, is a central mediator of Toll-like receptor 7 signaling. J Biol Chem 2005, 280:17005-17012.
11. Barnes BJ, Moore PA, Pitha PM. Virus-specific activation of a novel interferon regulatory factor, IRF-5, results in the induction of distinct interferon α genes. J Biol Chem 2001, 276:23382-23390.
12. Krausgruber T, Blazek K, Smallie T, Alzabin S, Lockstone H, Sahgal N, Hussell T, Feldmann M, Udalova IA. IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses. Nat Immunol 2011, 12:231-238.
13. Eyre S, Bowes J, Diogo D, Lee A, Barton A, Martin P, Zhernakova A, Stahl E, Viatte S, McAllister K, Amos CI, Padyukov L, Toes RE, Huizinga TW, Wijmenga C, Trynka G, Franke L, Westra HJ, Alfredsson L, Hu X, Sandor C, de Bakker PI, Davila S, Khor CC, Heng KK, Andrews R, Edkins S, Hunt SE, Langford C, Symmons D, et al. High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. Nat Genet 2012, 44:1336-1340.
14. Graham RR, Kozyrev SV, Baechler EC, Reddy MV, Plenge RM, Bauer JW, Ortmann WA, Koeuth T, Gonza´lez Escribano MF, Pons-Estel B, Petri M, Daly M, Gregersen PK, Marti´n J, Altshuler D, Behrens TW, Alarco´n-Riquelme ME,. Argentine and Spanish Collaborative Groups A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus. Nat Genet 2006, 38:550-555. Argentine and Spanish Collaborative Groups.
15. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, Healey LA, Kaplan SR, Liang MH, Luthra HS, Medsger TA, Mitchell DM, Neustadt DH, Pinals RS, Schaller JG, Sharp JT, Wilder RL, Hunder GG. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988, 31:315-324.
16. Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham CO, Birnbaum NS, Burmester GR, Bykerk VP, Cohen MD, Combe B, Costenbader KH, Dougados M, Emery P, Ferraccioli G, Hazes JM, Hobbs K, Huizinga TW, Kavanaugh A, Kay J, Kvien TK, Laing T, Mease P, Me´nard HA, Moreland LW, Naden RL, Pincus T, Smolen JS, Stanislawska-Biernat E, Symmons D, et al. 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum 2010, 62:2569-2581.
17. Gonzalez-Juanatey C, Llorca J, Martin J, Gonzalez-Gay MA. Carotid intima-media thickness predicts the development of cardiovascular events in patients with rheumatoid arthritis. Semin Arthritis Rheum 2009, 38:366-371.
18. Institut fu¨r Humangenetik Case-Control Studies: Tests for Deviation from Hardy-Weinberg Equilibrium and Tests for Association. [http://ihg.gsf.de/cgi-bin/hw/hwa1.pl], Institut fu¨r Humangenetik.
19. International HapMap Project. [http://hapmap.ncbi.nlm.nih.gov/].
20. Carmona FD, Martin JE, Beretta L, Simeo´n CP, Carreira PE, Callejas JL, Ferna´ndez-Castro M, Sa´ez-Comet L, Beltra´n E, Camps MT, Egurbide MV, Airo´ P, Scorza R, Lunardi C, Hunzelmann N, Riemekasten G, Witte T, Kreuter A, Distler JHW, Madhok R, Shiels P, van Laar JM, Fonseca C, Denton C, Herrick A, Worthington J, Schuerwegh AJ, Vonk MC, Voskuyl AE, et al. the Spanish Scleroderma Group The systemic lupus erythematosus IRF5 risk haplotype is associated with systemic sclerosis. PLoS One 2013, 8:e54419. the Spanish Scleroderma Group.
21. Fan JH, Gao LB, Pan XM, Li C, Liang WB, Liu J, Li Y, Zhang L. Association between IRF-5 polymorphisms and risk of acute coronary syndrome. DNA Cell Biol 2010, 29:19-23.
22. Vosslamber S, van Sijl A, Bos CL, Lubbers J, de Ridder S, Voskuyl AE, Nurmohamed MT, Verweij CL. Interferon regulatory factor 5 (IRF5) gene variant rs2004640 is associated with carotid intima media thickness in rheumatoid arthritis patients [abstract A1.77]. Ann Rheum Dis 2014, 73:A34.