Heart rate following short-term beta-blocker titration predicts all-cause mortality in elderly chronic heart failure patients: Insights from the CIBIS-ELD trial

European Journal of Heart Failure

Volumn 16, Issue 8, 2014, Pages 907-914

  Düngen, Hans Dirk ^a   Musial Bright, Lindy ^a   Inkrot, Simone ^a   Apostolovic̈, Svetlana ^b   Edelmann, Frank ^c   Lainščak, Mitja ^d   Šekularac, Nikola ^e   Störk, Stefan ^f   Tahirovic, Elvis ^a   Tscholl, Verena ^a   Krackhardt, Florian ^a   Loncar, Goran ^e   Trippel, Tobias D ^a   Gelbrich, Götz ^a,f,g  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b University Clinical Center   (Serbia)

^c UNIVERSITY OF GÖTTINGEN   (Germany)

^d UNIVERSITY CLINIC OF RESPIRATORY AND ALLERGIC DISEASES   (Slovenia)

^e University Hospital Zvezdara   (Serbia)

^f UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

^g UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Beta blockers; Elderly; Heart failure; Heart rate

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BISOPROLOL; CARVEDILOL; CARBAZOLE DERIVATIVE; PROPANOLAMINE DERIVATIVE;

AGED; ARTICLE; ATRIOVENTRICULAR BLOCK; BRADYCARDIA; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL TRIAL (TOPIC); DISEASE EXACERBATION; DRUG DOSE TITRATION; FATIGUE; FEMALE; FOLLOW UP; GERIATRICS; HAZARD RATIO; HEART FAILURE; HEART RATE; HEART VENTRICLE FUNCTION; HUMAN; HYPOTENSION; MAJOR CLINICAL STUDY; MALE; MORTALITY; NEW YORK HEART ASSOCIATION CLASS; PREDICTION; PRIORITY JOURNAL; RISK ASSESSMENT; SURVIVAL RATE; VERTIGO; CHRONIC DISEASE; CONTROLLED STUDY; DOSE RESPONSE; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME; VERY ELDERLY;

ADRENERGIC BETA-ANTAGONISTS; AGED; AGED, 80 AND OVER; BISOPROLOL; CARBAZOLES; CHRONIC DISEASE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HEART FAILURE; HEART RATE; HUMANS; MALE; MORTALITY; PROGNOSIS; PROPANOLAMINES; PROPORTIONAL HAZARDS MODELS; TREATMENT OUTCOME;

EID: 84905708370     PISSN: 13889842     EISSN: 18790844     Source Type: Journal    
DOI: 10.1002/ejhf.121     Document Type: Article

References (20)

1. McMurray JJ, Adamopoulos S, Anker SD, Auricchio A, Bohm M, Dickstein K, Falk V, Filippatos G, Fonseca C, Gomez-Sanchez MA, Jaarsma T, Kober L, Lip GY, Maggioni AP, Parkhomenko A, Pieske BM, Popescu BA, Ronnevik PK, Rutten FH, Schwitter J, Seferovic P, Stepinska J, Trindade PT, Voors AA, Zannad F, Zeiher A, Bax JJ, Baumgartner H, Ceconi C, Dean V, Deaton C, Fagard R, Funck-Brentano C, Hasdai D, Hoes A, Kirchhof P, Knuuti J, Kolh P, McDonagh T, Moulin C, Reiner Z, Sechtem U, Sirnes PA, Tendera M, Torbicki A, Vahanian A, Windecker S, Bonet LA, Avraamides P, Ben Lamin HA, Brignole M, Coca A, Cowburn P, Dargie H, Elliott P, Flachskampf FA, Guida GF, Hardman S, Iung B, Merkely B, Mueller C, Nanas JN, Nielsen OW, Orn S, Parissis JT, Ponikowski P,. ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: the Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. Eur J Heart Fail 2012; 14: 803-869.
2. Komajda M, Follath F, Swedberg K, Cleland J, Aguilar JC, Cohen-Solal A, Dietz R, Gavazzi A, Van Gilst WH, Hobbs R, Korewicki J, Madeira HC, Moiseyev VS, Preda I, Widimsky J, Freemantle N, Eastaugh J, Mason J,. The EuroHeart Failure Survey programme-a survey on the quality of care among patients with heart failure in Europe. Part 2: treatment. Eur Heart J 2003; 24: 464-474.
3. Ko DT, Hebert PR, Coffey CS, Curtis JP, Foody JM, Sedrakyan A, Krumholz HM,. Adverse effects of beta-blocker therapy for patients with heart failure: a quantitative overview of randomized trials. Arch Intern Med 2004; 164: 1389-1394.
4. Zugck C, Franke J, Gelbrich G, Frankenstein L, Scheffold T, Pankuweit S, Duengen HD, Regitz-Zagrosek V, Pieske B, Neumann T, Rauchhaus M, Angermann CE, Katus HA, Ertl GE, Stork S,. Implementation of pharmacotherapy guidelines in heart failure: experience from the German Competence Network Heart Failure. Clin Res Cardiol 2012; 101: 263-272.
5. Gelbrich G, Edelmann F, Inkrot S, Lainscak M, Apostolovic S, Neskovic AN, Waagstein F, Loeffler M, Anker SD, Dietz R, Dungen HD,. Cibis-Eld investigators Is target dose the treatment target? Uptitrating beta-blockers for heart failure in the elderly. Int J Cardiol 2012; 155: 160-166.
6. Brutsaert DL, Sys S, Gillebert TC,. Diastolic failure-pathophysiology and therapeutic implications. J Am Coll Cardiol 1993; 22: 318-325.
7. Colucci WS,. Molecular and cellular mechanisms of myocardial failure. Am J Cardiol 1997; 80: L15-L25.
8. Lowes BD, Gill EA, Abraham WT, Larrain JR, Robertson AD, Bristow MR, Gilbert EM,. Effects of carvedilol on left ventricular mass, chamber geometry, and mitral regurgitation in chronic heart failure. Am J Cardiol 1999; 83: 1201-1205.
9. Murray DR, Prabhu SD, Chandrasekar B,. Chronic beta-adrenergic stimulation induces myocardial proinflammatory cytokine expression. Circulation 2000; 101: 2338-2341.
10. Cullington D, Goode KM, Clark AL, Cleland JG,. Heart rate achieved or beta-blocker dose in patients with chronic heart failure: which is the better target? Eur J Heart Fail 2012; 14: 737-747.
11. Lechat P, Hulot JS, Escolano S, Mallet A, Leizorovicz A, Werhlen-Grandjean M, Pochmalicki G, Dargie H,. Heart rate and cardiac rhythm relationships with bisoprolol benefit in chronic heart failure in CIBIS II Trial. Circulation 2001; 103: 1428-1433.
12. Metra M, Torp-Pedersen C, Swedberg K, Cleland JG, Di Lenarda A, Komajda M, Remme WJ, Lutiger B, Scherhag A, Lukas MA, Charlesworth A, Poole-Wilson PA,. Influence of heart rate, blood pressure, and beta-blocker dose on outcome and the differences in outcome between carvedilol and metoprolol tartrate in patients with chronic heart failure: results from the COMET trial. Eur Heart J 2005; 26: 2259-2268.
13. Gullestad L, Wikstrand J, Deedwania P, Hjalmarson A, Egstrup K, Elkayam U, Gottlieb S, Rashkow A, Wedel H, Bermann G, Kjekshus J, Merit-Hf Study Group. What resting heart rate should one aim for when treating patients with heart failure with a beta-blocker? Experiences from the Metoprolol Controlled Release/Extended Release Randomized Intervention Trial in Chronic Heart Failure (MERIT-HF). J Am Coll Cardiol 2005; 45: 252-259.
14. McAlister FA, Wiebe N, Ezekowitz JA, Leung AA, Armstrong PW,. Meta-analysis: beta-blocker dose, heart rate reduction, and death in patients with heart failure. Ann Intern Med 2009; 150: 784-794.
15. Bohm M, Swedberg K, Komajda M, Borer JS, Ford I, Dubost-Brama A, Lerebours G, Tavazzi L, SHIFT Investigators. Heart rate as a risk factor in chronic heart failure (SHIFT): the association between heart rate and outcomes in a randomised placebo-controlled trial. Lancet 2010; 376: 886-894.
16. Dungen HD, Apostolovic S, Inkrot S, Tahirovic E, Topper A, Mehrhof F, Prettin C, Putnikovic B, Neskovic AN, Krotin M, Sakac D, Lainscak M, Edelmann F, Wachter R, Rau T, Eschenhagen T, Doehner W, Anker S, D, Waagstein F, Herrmann-Lingen C, Gelbrich G, Dietz R, Cibis-Eld investigators. Project Multicentre Trials in the Competence Network Heart Failure. Titration to target dose of bisoprolol vs. carvedilol in elderly patients with heart failure: the CIBIS-ELD trial. Eur J Heart Fail 2011; 13: 670-680.
17. Flannery G, Gehrig-Mills R, Billah B, Krum H,. Analysis of randomized controlled trials on the effect of magnitude of heart rate reduction on clinical outcomes in patients with systolic chronic heart failure receiving beta-blockers. Bisoprolol vs. carvedilol in elderly patients with heart failure: rationale and design of the CIBIS-ELD trial. Am J Cardiol 2008; 101: 865-869.
18. Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D,. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med 1999; 130: 461-470.
19. Remme WJ, McMurray JJ, Hobbs FD, Cohen-Solal A, Lopez-Sendon J, Boccanelli A, Zannad F, Rauch B, Keukelaar K, Macarie C, Ruzyllo W, Cline C, SHAPE Study Group. Awareness and perception of heart failure among European cardiologists, internists, geriatricians, and primary care physicians. Eur Heart J 2008; 29: 1739-1752.
20. Gustafsson F, Arnold JM,. Heart failure clinics and outpatient management: review of the evidence and call for quality assurance. Eur Heart J 2004; 25: 1596-1604.