Differential uptake of Tc-99m DMSA and Tc-99m EC in renal tubular disorders: Report of two cases and review of the literature

Indian Journal of Nuclear Medicine

Volumn 29, Issue 3, 2014, Pages 160-162

  Gorla, Arun Kumar Reddy ^a   Agrawal, Kanhaiyalal ^a   Sood, Ashwani ^a   Bhattacharya, Anish ^a   Mittal, Bhagwant Rai ^a  

^a POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

Author keywords

Fanconi syndrome; Lowe syndrome; renal tubular acidosis; Tc 99m DMSA scan; Tc 99m EC scan

Indexed keywords

ETARFOLATIDE TC 99M; SUCCIMER TC 99M;

ARTICLE; CASE REPORT; CHILD; CLINICAL EVALUATION; FAILURE TO THRIVE; HUMAN; HYDRATION; HYDRONEPHROSIS; IMAGE ANALYSIS; KIDNEY FUNCTION TEST; KIDNEY TUBULE ACIDOSIS; KIDNEY TUBULE BASEMENT MEMBRANE; MALE; PRESCHOOL CHILD; SCINTIGRAPHY;

EID: 84905683518     PISSN: 09723919     EISSN: 09740244     Source Type: Journal    
DOI: 10.4103/0972-3919.136571     Document Type: Article

References (16)

1. Yee CA, Lee HB, Blaufox MD. Tc-99m DMSA renal uptake: Influence of biochemical and physiologic factors. J Nucl Med 1981;22:1054-8.
2. Piepsz A, Ham HR. Pediatric applications of renal nuclear medicine. SeminNucl Med 2006;36:16-35.
3. Gordon I, Piepsz A, Sixt R. Auspices of Paediatric Committee of European Association of Nuclear Medicine. Guidelines for standard and diuretic renogram in children. Eur J Nucl Med Mol Imaging 2011;38:1175-88.
4. Mandell GA, Eggli DF, Gilday DL, Heyman S, Leonard JC, Miller JH, et al. Procedure guideline for renal cortical scintigraphy in children. Society of Nuclear Medicine. J Nucl Med 1997;38:1644-6.
5. Taylor A Jr, Lallone RL, Hagan PL. Optimal handling of dimercaptosuccinic acid for quantitative renal scanning. J Nucl Med 1980;21:1190-3.
6. Goldraich NP, Alvarenga AR, Goldraich IH, Ramos OL, Sigulem D. Renal accumulation of 99mTc-DMSA in the artificially perfused isolated rat kidney. J Urol 1985;134:1282-6.
7. Peters AM, Jones DH, Evans K, Gordon I. Two routes for 99mTc-DMSA uptake into the renal cortical tubular cell. Eur J Nucl Med 1988;14:555-61.
8. Christensen EI, Gburek J. Protein reabsorption in renal proximal tubule-function and dysfunction in kidney pathophysiology. PediatrNephrol 2004;19:714-21.
9. Muller-Suur R, Gutsche HU. Tubular reabsorption of technetium-99m-DMSA. J Nucl Med 1995;36:1654-8.
10. Lee BH, Lee SH, Choi HJ, Kang HG, Oh SW, Lee DS, et al. Decreased renal uptake of (99m) Tc-DMSA in patients with tubular proteinuria. Pediatr Nephrol 2009;24:2211-6.
11. Green DA, Davies SG. Dimercaptosuccinic acid distribution in renal tubular acidosis. Br J Radiol 1997;70:1291-2.
12. Caglar M, Topaloǧlu R. Reduced Tc-99m DMSA uptake in a patient with renal tubular acidosis: Effect of acid-base imbalance. Ann Nucl Med 2002;16:499-501.
13. Koca G, Atilgan HI, Demirel K, Diri A, Korkmaz M. Poor Tc-99m dimercaptosuccinic acid uptake, re-evaluation with Tc-99m MAG3 scintigraphy in Lowe syndrome. Indian J Nucl Med 2011;26:185-7.
14. Lowe M. Structure and function of the Lowe syndrome protein OCRL1. Traffic 2005;6:711-9.
15. Christensen EI, Birn H. Megalin and cubilin: Multifunctional endocytic receptors. Nat Rev Mol Cell Biol 2002;3:256-66.
16. Ozker K, Onsel C, Kabasakal L, Sayman HB, Uslu I, Bozluolçay S, et al. Technetium-99m-N, N-ethylenedicysteine-a comparative study of renal scintigraphy with technetium-99m-MAG3 and iodine-131-OIH in patients with obstructive renal disease. J Nucl Med 1994;35:840-5.