Urinary cell mRNA profiles and differential diagnosis of acute kidney graft dysfunction

Journal of the American Society of Nephrology

Volumn 25, Issue 7, 2014, Pages 1586-1597

  Matignon, Marie ^a,b   Ding, Ruchuang ^a   Dadhania, Darshana M ^a   Mueller, Franco B ^a   Hartono, Choli ^a   Snopkowski, Catherine ^a   Li, Carol ^a   Lee, John R ^a   Sjoberg, Daniel ^c   Seshan, Surya V ^a   Sharma, Vijay K ^a   Yang, Hua ^a   Nour, Bakr ^d   Vickers, Andrew J ^c   Suthanthiran, Manikkam ^a   Muthukumar, Thangamani ^a  

^a WEILL CORNELL MEDICAL CENTER   (United States)

^b UNIVERSITÉ PARIS EST CRÉTEIL   (France)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^d WEILL CORNELL MEDICAL COLLEGE   (Qatar)

Author keywords

[No Author keywords available]

Indexed keywords

ALTERNATIVE COMPLEMENT PATHWAY C3 C5 CONVERTASE; CD14 ANTIGEN; CD3 ANTIGEN; CREATININE; ENDOGLIN; MESSENGER RNA; MYCOPHENOLIC ACID; RNA 18S; TACROLIMUS; TOLL LIKE RECEPTOR 4; VIMENTIN;

ACUTE GRAFT REJECTION; ADAPTIVE IMMUNITY; ADULT; ANTIBODY MEDIATED REJECTION; ARTICLE; BK VIRUS INFECTION; CREATININE BLOOD LEVEL; DIAGNOSTIC TEST ACCURACY STUDY; DIAGNOSTIC VALUE; DIFFERENTIAL DIAGNOSIS; FEMALE; GRAFT RECIPIENT; HUMAN; HUMAN TISSUE; IMMUNOSUPPRESSIVE TREATMENT; INTERSTITIAL NEPHRITIS; KIDNEY ALLOGRAFT; KIDNEY BIOPSY; KIDNEY GRAFT; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; PRIORITY JOURNAL; RENAL GRAFT DYSFUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE; URINALYSIS; URINE VOLUME; ACUTE DISEASE; CYTOLOGY; GRAFT REJECTION; KIDNEY TRANSPLANTATION; KIDNEY TUBULE; PRIMARY GRAFT DYSFUNCTION; RENAL DYSFUNCTION; URINE; VALIDATION STUDY;

ACUTE ALLOGRAFT REJECTION; MRNA; RENAL DYSFUNCTION;

ACUTE DISEASE; DIAGNOSIS, DIFFERENTIAL; FEMALE; GRAFT REJECTION; HUMANS; KIDNEY TRANSPLANTATION; KIDNEY TUBULES; MALE; MIDDLE AGED; PRIMARY GRAFT DYSFUNCTION; RNA, MESSENGER; URINE;

EID: 84905676008     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2013080900     Document Type: Article

References (19)

1. Knechtle SJ, Pirsch JD: Early course of the patient with a kidney transplant. In: Kidney Transplantation: Principles and Practice, 6th Ed., edited by Morris PJ, Knechtle SJ, Philadelphia, Saunders, 2008, pp 210-219
2. Wilkinson A: The "first quarter": The first three months after transplant. In: Handbook of Kidney Transplantation, 5th Ed., edited by Danovitch GM, Philadelphia, Lippincott Willimas & Wilkins, 2010, pp 198-216
3. Al-Awwa IA, Hariharan S, First MR: Importance of allograft biopsy in renal transplant recipients: Correlation between clinical and histological diagnosis. Am J Kidney Dis 31[Suppl 1]: S15-S18, 1998
4. Pascual M, Vallhonrat H, Cosimi AB, Tolkoff-Rubin N, Colvin RB, Delmonico FL, Ko DS, Schoenfeld DA, Williams WW Jr.: The clinical usefulness of the renal allograft biopsy in the cyclosporine era: A prospective study. Transplantation 67: 737-741, 1999
5. Furness PN, Taub N; Convergence of European Renal Transplant PathologyAssessmentProcedures (CERTPAP)Project: International variation in the interpretation of renal transplant biopsies: Report of the CERTPAP Project. Kidney Int 60: 1998-2012, 2001
6. Williams WW, Taheri D, Tolkoff-Rubin N, Colvin RB: Clinical role of the renal transplant biopsy. Nat Rev Nephrol 8: 110-121, 2012
7. Li B, Hartono C, Ding R, Sharma VK, Ramaswamy R, Qian B, Serur D, Mouradian J, Schwartz JE, Suthanthiran M: Noninvasive diagnosis of renal-allograft rejection by measurement of messenger RNA for perforin and granzyme B in urine. N Engl J Med 344: 947-954, 2001
8. Muthukumar T, Dadhania D, Ding R, Snopkowski C, Naqvi R, Lee JB, Hartono C, Li B, Sharma VK, Seshan SV, Kapur S, Hancock WW, Schwartz JE, SuthanthiranM:Messenger RNA for FOXP3 in the urine of renal-allograft recipients. N Engl J Med 353: 2342-2351, 2005
9. Anglicheau D, Muthukumar T, Hummel A, Ding R, Sharma VK, Dadhania D, Seshan SV, Schwartz JE, Suthanthiran M: Discovery and validation of a molecular signature for the noninvasive diagnosis of human renal allograft fibrosis. Transplantation 93: 1136-1146, 2012
10. Suthanthiran M, Schwartz JE, Ding R, Abecassis M, Dadhania D, Samstein B, Knechtle SJ, Friedewald J, Becker YT, Sharma VK, Williams NM, Chang CS, Hoang C, Muthukumar T, August P, Keslar KS, Fairchild RL, Hricik DE, Heeger PS, Han L, Liu J, Riggs M, Ikle DN, Bridges ND, Shaked A; Clinical Trials in Organ Transplantation 04 (CTOT-04) Study Investigators: Urinary-cell mRNA profile and acute cellular rejection in kidney allografts. N Engl J Med 369: 20-31, 2013
11. Hair JF, Anderson RE, Tatham RL, Black WC, editors: Multivariate Analysis, Upper Saddle River, NJ, Prentice Hall, 1998
12. Vickers AJ, Elkin EB: Decision curve analysis: A novel method for evaluating prediction models. Med Decis Making 26: 565-574, 2006
13. Vickers AJ: Decision analysis for the evaluation of diagnostic tests, prediction models and molecular markers. Am Stat 62: 314-320, 2008
14. Steyerberg EW, Vickers AJ: Decision curve analysis: A discussion. Med Decis Making 28: 146-149, 2008
15. Kon SP, Templar J, Dodd SM, Rudge CJ, Raftery MJ: Diagnostic contribution of renal allograft biopsies at various intervals after transplantation. Transplantation 63: 547-550, 1997
16. Heyne N, Kemmner S, Schneider C, Nadalin S, Königsrainer A, Häring HU: Urinary neutrophil gelatinase-associated lipocalin accurately detects acute allograft rejection among other causes of acute kidney injury in renal allograft recipients. Transplantation 93: 1252-1257, 2012
17. De Serres SA, Mfarrej BG, Grafals M, Riella LV, Magee CN, Yeung MY, Dyer C, Ahmad U, Chandraker A, Najafian N: Derivation and validation of a cytokine-based assay to screen for acute rejection in renal transplant recipients. Clin J Am Soc Nephrol 7: 1018-1025, 2012
18. Lattenist L, Kers J, Claessen N, ten Berge IJ, Bemelman FJ, Florquin S, Roelofs JJ: Renal and urinary levels of endothelial protein C receptor correlate with acute renal allograft rejection. PLoS One 8: e64994, 2013
19. Solez K, Colvin RB, Racusen LC, Haas M, Sis B, Mengel M, Halloran PF, Baldwin W, Banfi G, Collins AB, Cosio F, David DS, Drachenberg C, Einecke G, Fogo AB, Gibson IW, Glotz D, Iskandar SS, Kraus E, Lerut E, Mannon RB, Mihatsch M, Nankivell BJ, Nickeleit V, Papadimitriou JC, Randhawa P, Regele H, Renaudin K, Roberts I, Seron D, Smith RN, Valente M: Banff 07 classification of renal allograft pathology: Updates and future directions. Am J Transplant 8: 753-760, 2008