Evolutionary history of tuberculosis shaped by conserved mutations in the PhoPR virulence regulator

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 31, 2014, Pages 11491-11496

  Gonzalo Asensio, Jesús ^a,b   Malaga, Wladimir ^c   Pawlik, Alexandre ^d   Astarie Dequeker, Catherine ^c   Passemar, Charlotte ^c   Moreau, Flavie ^c   Laval, Françoise ^c   Daffé, Mamadou ^c   Martin, Carlos ^a,b,e   Brosch, Roland ^d   Guilhot, Christophe ^c  

^a UNIVERSITY OF ZARAGOZA   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c INSTITUT DE PHARMACOLOGIE ET DE BIOLOGIE STRUCTURALE   (France)

^d INSTITUT PASTEUR   (France)

^e HOSPITAL UNIVERSITARIO MIGUEL SERVET   (Spain)

Author keywords

Adaptation; Evolution; Phylogeny; Zoonosis

Indexed keywords

BACTERIAL PROTEIN; EARLY SECRETORY ANTIGENIC TARGET 6; PHOP PROTEIN; PHOR PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL STRAIN; BACTERIAL VIRULENCE; CONTROLLED STUDY; DOWN REGULATION; GENE DELETION; GENE INSERTION; GENE LOCUS; GENE MUTATION; GENE TRANSFER; MYCOBACTERIUM AFRICANUM; MYCOBACTERIUM BOVIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; REGULON; SPAIN; TUBERCULOSIS;

ADAPTATION; EVOLUTION; PHYLOGENY; ZOONOSIS;

ALLELES; ANIMALS; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; BIOLOGICAL EVOLUTION; CATTLE; CONSERVED SEQUENCE; GENE DELETION; HOST-PATHOGEN INTERACTIONS; HUMANS; MUTAGENESIS, INSERTIONAL; MUTATION; MYCOBACTERIUM; MYCOBACTERIUM BOVIS; MYCOBACTERIUM TUBERCULOSIS; PHYLOGENY; POLYMORPHISM, SINGLE NUCLEOTIDE; TUBERCULOSIS; VIRULENCE;

EID: 84905661582     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1406693111     Document Type: Article

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