The first international mini-symposium on methionine restriction and lifespan

Frontiers in Genetics

Volumn 5, Issue MAY, 2014, Pages

  Ables, Gene P ^a   Brown Borg, Holly M ^b   Buffenstein, Rochelle ^c   Church, Christopher D ^d,n   Elshorbagy, Amany K ^e,f   Gladyshev, Vadim N ^g   Huang, Tsang hai ^h   Miller, Richard A ⁱ   Mitchell, James R ^j   Richie, John P ^k   Rogina, Blanka ^l   Stipanuk, Martha H ^m   Orentreich, David S ^a   Orentreich, Norman ^a  

^a Orentreich Foundation for the Advancement of Science Inc   (United States)

^b UNIVERSITY OF NORTH DAKOTA SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^c UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^d Harwell Science and Innovation Campus ^*  (United Kingdom)

^e UNIVERSITY OF OXFORD   (United Kingdom)

^f ALEXANDRIA UNIVERSITY   (Egypt)

^g BRIGHAM AND WOMEN S HOSPITAL   (United States)

^h NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

ⁱ UNIVERSITY OF MICHIGAN   (United States)

^j HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^k PENNSYLVANIA STATE UNIVERSITY   (United States)

^l UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^m Department of Obstetrics Gynecology   (United States)

ⁿ YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

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Author keywords

Aging and longevity; Animal models; Lifespan; Methionine restriction

Indexed keywords

EID: 84905660092     PISSN: None     EISSN: 16648021     Source Type: Journal    
DOI: 10.3389/fgene.2014.00122     Document Type: Article

References (5)

1. Orentreich, N., Matias, J. R., DeFelice, A., and Zimmerman, J. A. (1993). Low methionine ingestion by rats extends life span. J. Nutr. 123, 269-274.
2. Ables, G. P., Perrone, C. E., Orentreich, D., and Orentreich, N. (2012). Methionine-restricted C57BL/6J mice are resistant to diet-induced obesity and insulin resistance but have low bone density. PLoS ONE 7:e51357. doi: 10.1371/journal.pone.0051357
3. Miller, R. A., Buehner, G., Chang, Y., Harper, J. M., Sigler, R., and Smith-Wheelock, M. (2005). Methionine-deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance. Aging Cell 4, 119-125. doi: 10.1111/j.1474-9726.2005.00152.x
4. Richie, J. P. Jr., Leutzinger, Y., Parthasarathy, S., Malloy, V., Orentreich, N., and Zimmerman, J. A. (1994). Methionine restriction increases blood glutathione and longevity in F344 rats. FASEB J. 8, 1302-1307.
5. Sanchez-Roman, I., and Barja, G. (2013). Regulation of longevity and oxidative stress by nutritional interventions: role of methionine restriction. Exp. Gerontol. 48, 1030-1042. doi: 10.1016/j.exger.2013.02.021