A question of nature: Some antigens are bound to be allergens

Frontiers in Immunology

Volumn 5, Issue AUG, 2014, Pages

  Pontes de Carvalho, Lain ^a,b   Menge, José ^a,c  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

^b Social Changes Asthma and Allergy in Latin America SCAALA Program   (Brazil)

^c Faculty of Medicine of Petropolis FMP FASE   (Brazil)

Author keywords

Allergen; Allergenicity; Allergy; Cross reactivity; Evolution; Helminth; Th2

Indexed keywords

EID: 84905642365     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2014.00373     Document Type: Note

References (30)

1. Fitzsimmons CM, Falcone FH, Dunne DW. Helminth allergens, parasite-specific IgE, and its protective role in human immunity. Front Immunol (2014) 5:61. doi: 10.3389/fimmu.2014.00061
2. Fitzsimmons CM, Dunne DW. Survival of the fittest: allergology or parasitology? Trends Parasitol (2009) 25:447-51. doi:10.1016/j.pt.2009.07.004
3. Hagan P, Blumenthal UJ, Dunn D, Simpson AJ, Wilkins HA. Human IgE, IgG4 and resistance to reinfection with Schistosoma haematobium. Nature (1991) 349:243-5. doi:10.1038/349243a0
4. Pritchard DI, Quinnell RJ, Walsh EA. Immunity in humans to Necator americanus: IgE, parasite weight and fecundity. Parasite Immunol (1995) 17:71-5. doi:10.1111/j.1365-3024.1995.tb00968.x
5. Bethony J, Loukas A, Smout M, Brooker S, Mendez S, Plieskatt J, et al. Antibodies against a secreted protein from hookworm larvae reduce the intensity of hookworm infection in humans and vaccinated laboratory animals. FASEB J (2005) 19:1743-5.
6. Pinot de Moira A, Fulford AJ, Kabatereine NB, Ouma JH, Booth M, Dunne DW. Analysis of complex patterns of human exposure and immunity to Schistosomiasis mansoni: the influence of age, sex, ethnicity and IgE. PLoS Negl Trop Dis (2010) 4:e820. doi:10.1371/journal.pntd.0000820
7. Allen JE, Maizels RM. Diversity and dialogue in immunity to helminths. Nat Rev Immunol (2011) 11:375-88. doi:10.1038/nri2992
8. Pinot de Moira A, Jones FM, Wilson S, Tukahebwa E, Fitzsimmons CM, Mwatha JK, et al. Effects of treatment on IgE responses against parasite allergen-like proteins and immunity to reinfection in childhood schistosome and hookworm coinfections. Infect Immun (2013) 81:23-32. doi:10.1128/IAI.00748-12
9. Del Prete G. Human Th1 and Th2 lymphocytes: their role in the pathophysiology of atopy. Allergy (1992) 47:450-5. doi:10.1111/j.1398-9995.1992.tb00662.x
10. Palm NW, Rosenstein RK, Yu S, Schenten DD, Florsheim E, Medzhitov R. Bee venom phospholipase A2 induces a primary type 2 response that is dependent on the receptor ST2 and confers protective immunity. Immunity (2013) 39:976-85. doi:10.1016/j.immuni.2013.10.006
11. Thomas WR, Smith WA, Hales BJ. The allergenic specificities of the house dust mite. Chang Gung Med J (2004) 27:563-9.
12. Weghofer M, Dall'Antonia Y, Grote M, Stöcklinger A, Kneidinger M, Balic N, et al. Characterization of Der p 21, a new important allergen derived from the gut of house dust mites. Allergy (2008) 63:758-67. doi:10.1111/j.1398-9995.2008.01647.x
13. Shakib F, Ghaemmaghami AM, Sewell HF. The molecular basis of allergenicity. Trends Immunol (2008) 29:633-42. doi:10.1016/j.it.2008.08.007
14. Machado DC, Horton D, Harrop R, Peachell PT, Helm BA. Potential allergens stimulate the release of mediators of the allergic response from cells of mast cell lineage in the absence of sensitization with antigen-specific IgE. Eur J Immunol (1996) 26:2972-80. doi:10.1002/eji.1830261224
15. Woolcock AJ, Peat JK. Evidence for the increase in asthma worldwide. Ciba Found Symp (1997) 206:122-34.
16. Upton MN, McConnachie A, McSharry C, Hart CL, Smith GD, Gillis CR, et al. Intergenerational 20 year trends in the prevalence of asthma and hay fever in adults: the Midspan family study surveys of parents and offspring. Br Med J (2000) 321:88-92. doi:10.1136/bmj.321.7253.88
17. Davis MM. T cell receptor gene diversity and selection. Annu Rev Biochem (1990) 59:475-96. doi:10.1146/annurev.bi.59.070190.002355
18. Cabaniols JP, Fazilleau N, Casrouge A, Kourilsky P, Kanellopoulos JM. Most alpha/beta T cell receptor diversity is due to terminal deoxynucleotidyl transferase. J Exp Med (2001) 194:1385-90. doi:10.1084/jem.194.9
19. Benedict CL, Gilfillan S, Thai TH, Kearney JF. Terminal deoxynucleotidyl transferase and repertoire development. Immunol Rev (2000) 175:150-7. doi:10.1111/j.1600-065X.2000.imr017518.x
20. Rose S, Lichtenheld M, Foote MR, Adkins B. Murine neonatal CD4+ cells are poised for rapid Th2 effector-like function. J Immunol (2007) 178:2667-78. doi:10.4049/jimmunol.178.5.2667
21. Hebel K, Weinert S, Kuropka B, Knolle J, Kosak B, Jorch G, et al. CD4+ T cells from human neonates and infants are poised spontaneously to run a nonclassical IL-4 program. J Immunol (2014) 192:5160-70. doi:10.4049/jimmunol.1302539
22. Inman CF, Laycock GM, Mitchard L, Harley R, Warwick J, Burt R, et al. Neonatal colonisation expands a specific intestinal antigen-presenting cell subset prior to CD4 T-cell expansion, without altering T-cell repertoire. PLoS One (2012) 7:e33707. doi:10.1371/journal.pone.0033707
23. Lindner C, Wahl B, Föhse L, Suerbaum S, Macpherson AJ, Prinz I, et al. Age, microbiota, and T cells shape diverse individual IgA repertoires in the intestine. J Exp Med (2012) 209:365-77. doi:10.1084/jem.20111980
24. Profet M. The function of allergy: immunological defense against toxins. Q Rev Biol (1991) 66:23-62. doi:10.1086/417049
25. Palm NW, Rosenstein RK, Medzhitov R. Allergic host defences. Nature (2012) 484:465-72. doi:10.1038/nature11047
26. Marichal T, Starkl P, Reber LL, Kalesnikoff J, Oettgen HC, Tsai M. A beneficial role for immunoglobulin E in host defense against honeybee venom. Immunity (2013) 39:963-75. doi:10.1016/j.immuni.2013.10.005
27. Wang Y, Jackson KJ, Chen Z, Gaëta BA, Siba PM, Pomat W, et al. IgE sequences in individuals living in an area of endemic parasitism show little mutational evidence of antigen selection. Scand J Immunol (2011) 73:496-504. doi:10.1111/j.1365-3083.2011.02525.x
28. Kerzel S, Rogosch T, Struecker B, Maier RF, Zemlin M. IgE transcripts in the circulation of allergic children reflect a classical antigen-driven B cell response and not a superantigen-like activation. J Immunol (2010) 185(4):2253-60. doi:10.4049/jimmunol.0902942
29. McSorley HJ, Maizels RM. Helminth infections and host immune regulation. Clin Microbiol Rev (2012) 25:585-608. doi:10.1128/CMR.05040-11
30. Suzuki R, Leach S, Liu W, Ralston E, Scheffel J, Zhang W, et al. Molecular editing of cellular responses by the high-affinity receptor for IgE. Science (2014) 343:1021-5. doi:10.1126/science.1246976