HRAS is silenced by two neighboring G-quadruplexes and activated by MAZ, a zinc-finger transcription factor with DNA unfolding property

Nucleic Acids Research

Volumn 42, Issue 13, 2014, Pages 8379-8388

  Cogoi, Susanna ^a   Shchekotikhin, Andrey E ^b,c   Xodo, Luigi E ^a  

^a Section of Oncology and Molecular Pathology   (Italy)

^b GAUSE INSTITUTE OF NEW ANTIBIOTICS   (Russian Federation)

^c MENDELEEV UNIVERSITY OF CHEMICAL TECHNOLOGY OF RUSSIA   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRATIOPHENEDIONE 1; ANTINEOPLASTIC AGENT; GLUTATHIONE TRANSFERASE; GUANINE QUADRUPLEX; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR MAZ; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; BLADDER CANCER CELL LINE; COMPLEX FORMATION; CONTROLLED STUDY; DNA CONFORMATION; DNA HYBRIDIZATION; DNA UNFOLDING; DRUG DESIGN; DRUG DNA BINDING; DRUG MECHANISM; DRUG STRUCTURE; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENE ACTIVATION; GENE REPRESSION; GENE SILENCING; MOLECULAR DYNAMICS; MOLECULARLY TARGETED THERAPY; MUTATIONAL ANALYSIS; NUCLEIC ACID STRUCTURE, METABOLISM AND FUNCTION; NUCLEOTIDE MOTIF; ONCOGENE H RAS; POINT MUTATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA INTERACTION; QUADRUPLEX FORMING MOTIF; STRUCTURE ACTIVITY RELATION; TRANSCRIPTION INITIATION SITE; TRANSCRIPTION REGULATION;

CELL LINE, TUMOR; DNA; DNA-BINDING PROTEINS; G-QUADRUPLEXES; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; HUMANS; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS P21(RAS); TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION; URINARY BLADDER NEOPLASMS;

EID: 84905565068     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gku574     Document Type: Article

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