The molecular signature of impaired diabetic wound healing identifies serpinB3 as a healing biomarker

Diabetologia

Volumn 57, Issue 9, 2014, Pages 1947-1956

  Fadini, Gian Paolo ^a,b   Albiero, Mattia ^b   Millioni, Renato ^a   Poncina, Nicol ^a,b   Rigato, Mauro ^a   Scotton, Rachele ^a   Boscari, Federico ^a   Brocco, Enrico ^c   Arrigoni, Giorgio ^a   Villano, Gianmarco ^a   Turato, Cristian ^a   Biasiolo, Alessandra ^a   Pontisso, Patrizia ^a   Avogaro, Angelo ^a,b  

^a UNIVERSITY OF PADOVA   (Italy)

^b VENETIAN INSTITUTE OF MOLECULAR MEDICINE   (Italy)

^c Interventional Radiology Unit   (Italy)

Author keywords

Animal models; Biomarkers; Chronic ulcers; Pathogenesis; Proteomics

Indexed keywords

ALPHA 1 ANTITRYPSIN; ALPHA 2 MACROGLOBULIN; ALPHA ACTININ 4; BIOLOGICAL MARKER; CALPASTATIN; CASPASE 14; CLUSTERIN; DNA BINDING PROTEIN; ELAFIN; FILAGGRIN; GLUCOSE; HAPTOGLOBIN; HEMOGLOBIN A1C; INITIATION FACTOR 5A; INTER ALPHA TRYPSIN INHIBITOR; INVOLUCRIN; KININOGEN; LACTOFERRIN; LEUKOCYTE ELASTASE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MESSENGER RNA; MYELOBLASTIN; PEPTIDES AND PROTEINS; PROTEIN S 100; PROTEINASE INHIBITOR; SERINE PROTEINASE; SERINE PROTEINASE INHIBITOR; SERPINB3; SERUM ALBUMIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; SQUAMOUS CELL CARCINOMA-RELATED ANTIGEN; TUMOR ANTIGEN; SERPIN B3 PROTEIN;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY MASS; CELL DIFFERENTIATION; CEREBROVASCULAR DISEASE; CHOLESTEROL BLOOD LEVEL; CHRONIC KIDNEY FAILURE; CLINICAL ARTICLE; CONTROLLED STUDY; DEBRIDEMENT; DIABETIC FOOT; DIABETIC NEUROPATHY; DIABETIC RETINOPATHY; DISEASE DURATION; FEMALE; GENE OVEREXPRESSION; GLUCOSE BLOOD LEVEL; HINDLIMB; HUMAN; HUMAN TISSUE; IN VIVO STUDY; LIMB ISCHEMIA; MALE; MASS SPECTROMETRY; MOUSE; NONHUMAN; PERIPHERAL VASCULAR DISEASE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONTENT; PROTEIN EXPRESSION; PROTEOMICS; SKIN BIOPSY; WAIST CIRCUMFERENCE; WOUND HEALING; WOUND HEALING IMPAIRMENT; WOUND INFECTION; ADOLESCENT; AGED; ANIMAL; GENETICS; METABOLISM; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY; VERY ELDERLY; YOUNG ADULT; DIABETIC PATIENT; MAJOR CLINICAL STUDY; OUTCOME ASSESSMENT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANIMALS; ANTIGENS, NEOPLASM; BIOLOGICAL MARKERS; DIABETIC FOOT; FEMALE; HUMANS; MALE; MIDDLE AGED; SERPINS; WOUND HEALING; YOUNG ADULT;

EID: 84905562433     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-014-3300-2     Document Type: Article

References (28)

1. Seshasai SR, Kaptoge S, Thompson A, et al. (2011) Diabetes mellitus, fasting glucose, and risk of cause-specific death. N Engl J Med 364:829-841
2. Morbach S, Furchert H, Groblinghoff U, et al. (2012) Long-term prognosis of diabetic foot patients and their limbs: amputation and death over the course of a decade. Diabetes Care 35:2021-2027
3. Schaper NC, Apelqvist J, Bakker K (2012) Reducing lower leg amputations in diabetes: a challenge for patients, healthcare providers and the healthcare system. Diabetologia 55:1869-1872
4. Gary Sibbald R, Woo KY (2008) The biology of chronic foot ulcers in persons with diabetes. Diabetes Metab Res Rev 24(Suppl 1):S25-S30
5. Clark RA (1985) Cutaneous tissue repair: basic biologic considerations. I. J Am Acad Dermatol 13:701-725
6. Broughton G 2nd, Janis JE, Attinger CE (2006) The basic science of wound healing. Plast Reconstr Surg 117:12S-34S
7. American Diabetes Association (1999) Consensus Development Conference on Diabetic Foot Wound Care: 7-8 April 1999, Boston, Massachusetts. Diabetes Care 22:1354-1360
8. Kussmann M, Raymond F, Affolter M (2006) OMICS-driven biomarker discovery in nutrition and health. J Biotechnol 124:758-787
9. Gjesing AP, Pedersen O (2012) 'Omics'-driven discoveries in prevention and treatment of type 2 diabetes. Eur J Clin Invest 42:579-588
10. Eming SA, Koch M, Krieger A, et al. (2010) Differential proteomic analysis distinguishes tissue repair biomarker signatures in wound exudates obtained from normal healing and chronic wounds. J Proteome Res 9:4758-4766
11. Krisp C, Jacobsen F, McKay MJ, et al. (2013) Proteome analysis reveals antiangiogenic environments in chronic wounds of diabetes mellitus type 2 patients. Proteomics 13:2670-2681
12. Sweitzer SM, Fann SA, Borg TK, Baynes JW, Yost MJ (2006) What is the future of diabetic wound care? Diabetes Educ 32:197-210
13. Ross PL, Huang YN, Marchese JN, et al. (2004) Multiplexed protein quantitation in Saccharomyces cerevisiae using amine-reactive isobaric tagging reagents. Mol Cell Proteomics 3:1154-1169
14. da Huang W, Sherman BT, Lempicki RA (2009) Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 4:44-57
15. Turato C, Biasiolo A, Pengo P, et al. (2011) Increased antiprotease activity of the SERPINB3 polymorphic variant SCCA-PD. Exp Biol Med (Maywood) 236:281-290
16. Villano G, Quarta S, Ruvoletto MG, et al. (2010) Role of squamous cell carcinoma antigen-1 on liver cells after partial hepatectomy in transgenic mice. Int J Mol Med 25:137-143
17. Fadini GP, Albiero M, Menegazzo L, et al. (2010) The redox enzyme p66Shc contributes to diabetes and ischemia-induced delay in cutaneous wound healing. Diabetes 59:2306-2314
18. Mehta TS, Zakharkin SO, Gadbury GL, Allison DB (2006) Epistemological issues in omics and high-dimensional biology: give the people what they want. Physiol Genomics 28:24-32
19. Kirk P, Witkover A, Bangham CR, et al. (2013) Balancing the robustness and predictive performance of biomarkers. J Comput Biol 20:979-989
20. Gatto M, Iaccarino L, Ghirardello A, et al. (2013) Serpins, immunity and autoimmunity: old molecules, new functions. Clin Rev Allergy Immunol 45:267-280
21. Quarta S, Vidalino L, Turato C, et al. (2010) SERPINB3 induces epithelial-mesenchymal transition. J Pathol 221:343-356
22. Villano G, Lunardi F, Turato C, et al. (2012) Increased Th1 immune response in SERPINB3 transgenic mice during acute liver failure. Exp Biol Med (Maywood) 237:1474-1482
23. Vidalino L, Doria A, Quarta S, et al. (2009) SERPINB3, apoptosis and autoimmunity. Autoimmun Rev 9:108-112
24. Villano G, Ruvoletto M, Ceolotto G, et al. (2013) SERPINB3 is associated with longer survival in transgenic mice. Sci Rep 3:3056
25. Dinh T, Tecilazich F, Kafanas A, et al. (2012) Mechanisms involved in the development and healing of diabetic foot ulceration. Diabetes 61:2937-2947
26. Menghini R, Uccioli L, Vainieri E, et al. (2013) Expression of tissue inhibitor of metalloprotease 3 is reduced in ischemic but not neuropathic ulcers from patients with type 2 diabetes mellitus. Acta Diabetol 50:907-910
27. Schwanhausser B, Busse D, Li N, et al. (2011) Global quantification of mammalian gene expression control. Nature 473:337-342
28. Hamanaka S, Ujihara M, Numa F, Kato H (1997) Serum level of squamous cell carcinoma antigen as a new indicator of disease activity in patients with psoriasis. Arch Dermatol 133:393-395