HIV-derived ssRNA binds to TLR8 to induce inflammation-driven macrophage foam cell formation

PLoS ONE

Volumn 9, Issue 8, 2014, Pages

  Bernard, Mark A ^a   Han, Xinbing ^a,c   Inderbitzin, Sonya ^a   Agbim, Ifunanya ^a   Zhao, Hui ^a,b   Koziel, Henry ^a   Tachado, Souvenir D ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b SHANXI MEDICAL UNIVERSITY   (China)

^c BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MYELOID DIFFERENTIATION FACTOR 88; SINGLE STRANDED RNA; SMALL INTERFERING RNA; TOLL LIKE RECEPTOR 8; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; VIRUS RNA; CHLOROQUINE; HYDRAZONE DERIVATIVE; MYD88 PROTEIN, HUMAN; N'-(3,4-DIHYDROXYBENZYLIDENE)-3-HYDROXY-2-NAPHTHAHYDRAZIDE; NEUTRALIZING ANTIBODY; PROTEIN BINDING; TLR8 PROTEIN, HUMAN; TUMOR NECROSIS FACTOR ALPHA;

ACIDIFICATION; ADULT; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE RELEASE; DOWNSTREAM PROCESSING; EMBRYO; ENDOCYTOSIS; FLOW CYTOMETRY; FLUORESCENCE RESONANCE ENERGY TRANSFER; FOAM CELL; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFLAMMATION; LUNG ALVEOLUS MACROPHAGE; MACROPHAGE MIGRATION; MYD88 GENE; NORMAL HUMAN; PROTEIN RNA BINDING; SIGNAL TRANSDUCTION; AGONISTS; ANTAGONISTS AND INHIBITORS; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; ENDOSOME; GENE EXPRESSION REGULATION; GENETICS; HEK293 CELL LINE; LUNG LAVAGE; MACROPHAGE; METABOLISM; PATHOLOGY; PH; PRIMARY CELL CULTURE;

ANTIBODIES, NEUTRALIZING; BRONCHOALVEOLAR LAVAGE FLUID; CHLOROQUINE; ENDOCYTOSIS; ENDOSOMES; FOAM CELLS; GENE EXPRESSION REGULATION; HEK293 CELLS; HIV; HUMANS; HYDRAZONES; HYDROGEN-ION CONCENTRATION; INFLAMMATION; MACROPHAGES; MACROPHAGES, ALVEOLAR; MYELOID DIFFERENTIATION FACTOR 88; PRIMARY CELL CULTURE; PROTEIN BINDING; RNA, VIRAL; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 8; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84905457792     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0104039     Document Type: Article

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