Maternal propensity for infections and risk of childhood asthma: A registry-based cohort study

The Lancet Respiratory Medicine

Volumn 2, Issue 8, 2014, Pages 631-637

  Stokholm, Jakob ^a,b,c   Sevelsted, Astrid ^a,b   Bønnelykke, Klaus ^a,b   Bisgaard, Hans ^a,b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^c NAESTVED HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; CORTICOSTEROID; ANTIINFECTIVE AGENT;

ARTICLE; ASTHMA; CHILD; CHILDHOOD DISEASE; COHORT ANALYSIS; DISEASE REGISTRY; DOSE RESPONSE; DRUG USE; FEMALE; HOSPITAL ADMISSION; HUMAN; INFECTION; MAJOR CLINICAL STUDY; MATERNAL TREATMENT; OUTPATIENT CARE; PREGNANCY; PRIORITY JOURNAL; PROSPECTIVE STUDY; RESPIRATORY TRACT INFECTION; RISK ASSESSMENT; RISK FACTOR; URINARY TRACT INFECTION; ADOLESCENT; ADULT; AMBULATORY CARE; CHEMICALLY INDUCED; DENMARK; DISEASE PREDISPOSITION; HOSPITALIZATION; INCIDENCE; INFANT; INHALATIONAL DRUG ADMINISTRATION; MATERNAL CARE; MOTHER; NEWBORN; POSTNATAL CARE; PREGNANCY COMPLICATIONS, INFECTIOUS; PRENATAL CARE; PRENATAL EXPOSURE; PRESCHOOL CHILD; PRESCRIPTION; REGISTER; STATISTICS AND NUMERICAL DATA; TIME; YOUNG ADULT;

ADMINISTRATION, INHALATION; ADOLESCENT; ADRENAL CORTEX HORMONES; ADULT; AMBULATORY CARE; ANTI-BACTERIAL AGENTS; ASTHMA; CHILD; CHILD, PRESCHOOL; DENMARK; DISEASE SUSCEPTIBILITY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG PRESCRIPTIONS; FEMALE; HOSPITALIZATION; HUMANS; INCIDENCE; INFANT; INFANT, NEWBORN; MOTHERS; POSTNATAL CARE; PRECONCEPTION CARE; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; PREGNANCY TRIMESTERS; PRENATAL CARE; PRENATAL EXPOSURE DELAYED EFFECTS; PROSPECTIVE STUDIES; REGISTRIES; TIME FACTORS; YOUNG ADULT;

EID: 84905450083     PISSN: 22132600     EISSN: 22132619     Source Type: Journal    
DOI: 10.1016/S2213-2600(14)70152-3     Document Type: Article

References (22)

1. Stensballe LG, Simonsen J, Jensen SM, Bønnelykke K, Bisgaard H Use of antibiotics during pregnancy increases the risk of asthma in early childhood. J Pediatr 2012, 162:832. 38.e3.
2. McKeever TM, Lewis SA, Smith C, Hubbard R The importance of prenatal exposures on the development of allergic disease: a birth cohort study using the West Midlands general practice database. Am J Respir Crit Care Med 2002, 166:827-832.
3. Rusconi F, Galassi C, Forastiere F, et al. Maternal complications and procedures in pregnancy and at birth and wheezing phenotypes in children. Am J Respir Crit Care Med 2007, 175:16-21.
4. Bisgaard H, Hermansen MN, Buchvald F, et al. Pathogenic bacteria colonizing the airways in asymptomatic neonates stimulates topical inflammatory mediator release. N Engl J Med 2007, 357:1487-1495.
5. Ege MJ, Mayer M, Normand A-C, et al. Exposure to environmental microorganisms and childhood asthma. N Engl J Med 2011, 364:701-709.
6. Prescott SL Early-life environmental determinants of allergic diseases and the wider pandemic of inflammatory noncommunicable diseases. J Allergy Clin Immunol 2013, 131:23-30.
7. Wallach Kildemoes H, Toft Sørensen H, Hallas J The Danish National Prescription Registry. Scand J Public Health 2011, 39:38-41.
8. Rostgaard K Methods for stratification of person-time and events-a prerequisite for Poisson regression and SIR estimation. Epidemiol Perspect Innov 2008, 5:7.
9. Pedersen CB, Gøtzsche H, Møller JO, Mortensen PB The Danish Civil Registration System. A cohort of eight million persons. Dan Med Bull 2006, 53:441-449.
10. Andersen TF, Madsen M, Jørgensen J, Mellemkjoer L, Olsen JH The Danish National Hospital Register. A valuable source of data for modern health sciences. Dan Med Bull 1999, 46:263-268.
11. Jensen Aø, Nielsen GL, Ehrenstein V Validity of asthma diagnoses in the Danish National Registry of Patients, including an assessment of impact of misclassification on risk estimates in an actual dataset. Clin Epidemiol 2010, 2:67-72.
12. Moth G, Vedsted P, Schiøtz P Identification of asthmatic children using prescription data and diagnosis. Eur J Clin Pharmacol 2007, 63:605-611.
13. Moth G, Vedsted P, Schiøtz PO National registry diagnoses agree with medical records on hospitalized asthmatic children. Acta Paediatr 2007, 96:1470-1473.
14. Bønnelykke K, Sleiman P, Nielsen K, et al. A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations. Nat Genet 2014, 46:51-55.
15. Benn CS, Thorsen P, Jensen JS, et al. Maternal vaginal microflora during pregnancy and the risk of asthma hospitalization and use of antiasthma medication in early childhood. J Allergy Clin Immunol 2002, 110:72-77.
16. Bisgaard H, Li N, Bonnelykke K, et al. Reduced diversity of the intestinal microbiota during infancy is associated with increased risk of allergic disease at school age. J Allergy Clin Immunol 2011, 128:646. 52.e5.
17. Cerf-Bensussan N, Gaboriau-Routhiau V The immune system and the gut microbiota: friends or foes?. Nat Rev Immunol 2010, 10:735-744.
18. Stokholm J, Schjørring S, Eskildsen C, et al. Antibiotic use during pregnancy alters the commensal vaginal microbiota. Clin Microbiol Infect 2013, published online Oct 1. 10.1111/1469-0691.12411.
19. Holt PG, Sly PD Viral infections and atopy in asthma pathogenesis: new rationales for asthma prevention and treatment. Nat Med 2012, 18:726-735.
20. Bisgaard H, Bønnelykke K, Stokholm J Immune-mediated diseases and microbial exposure in early life. Clin Exp Allergy 2014, 44:475-481.
21. Calişkan M, Bochkov YA, Kreiner-Møller E, et al. Rhinovirus wheezing illness and genetic risk of childhood-onset asthma. N Engl J Med 2013, 368:1398-1407.
22. Moffatt MF, Kabesch M, Liang L, et al. Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature 2007, 448:470-473.