Electrospun DOXY-h loaded-poly(acrylic acid) nanofiber mats: In vitro drug release and antibacterial properties investigation

Journal of Biomaterials Science, Polymer Edition

Volumn 25, Issue 12, 2014, Pages 1292-1305

  Khampieng, Thitikan ^a   Wnek, Gary E ^b   Supaphol, Pitt ^a  

^a CHULALONGKORN UNIVERSITY   (Thailand)

^b Case Western Reserve University   (United States)

Author keywords

doxycycline hyclate; electrospinning; in vitro drug release; poly(acrylic acid) nanofiber mats

Indexed keywords

BACTERIA; CARBOXYLIC ACIDS; ELECTROSPINNING; SCANNING ELECTRON MICROSCOPY;

ANTIBACTERIAL PROPERTIES; DOXYCYCLINE; ELECTROSPINNING TECHNIQUES; FICKIAN DIFFUSION MECHANISM; IN-VITRO; NANOFIBER MATS; STREPTOCOCCUS AGALACTIAE; UV-VIS SPECTROPHOTOMETRY;

NANOFIBERS;

DOXYCYCLINE HYCLATE; NANOFIBER; POLYACRYLIC ACID; ACRYLIC ACID RESIN; ANTIINFECTIVE AGENT; CARBOPOL 940; DOXYCYCLINE; DRUG CARRIER;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC SENSITIVITY; ARTICLE; CHEMICAL COMPOSITION; CONTROLLED STUDY; DISK DIFFUSION; DRUG ADSORPTION; DRUG RELEASE; DRUG STABILITY; ELECTROSPINNING; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HYDROGEN BOND; IN VITRO STUDY; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; QUALITATIVE ANALYSIS; SCANNING ELECTRON MICROSCOPY; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS AGALACTIAE; ULTRAVIOLET SPECTROPHOTOMETRY; WOUND CARE; WOUND DRESSING; BACTERIA; CHEMISTRY; DRUG EFFECTS; KINETICS; NANOTECHNOLOGY; TEMPERATURE;

NEGIBACTERIA; POSIBACTERIA; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS AGALACTIAE;

ACRYLIC RESINS; ANTI-BACTERIAL AGENTS; BACTERIA; DOXYCYCLINE; DRUG CARRIERS; DRUG LIBERATION; KINETICS; NANOFIBERS; NANOTECHNOLOGY; TEMPERATURE;

EID: 84905385777     PISSN: 09205063     EISSN: 15685624     Source Type: Journal    
DOI: 10.1080/09205063.2014.929431     Document Type: Article

References (26)

1. Cogen AL, Nizet V, Gallo RL. Skin microbiota: a source of disease or defence? Br. J. Dermatol. 2008;158:442-455.
2. Mackowiak PA. The normal microbial flora. N. Engl. J. Med. 1982;307:83-93.
3. National Institutes of Health (US). Biological Sciences Curriculum Study. NIH curriculum supplement series [Internet]. Bethesda (MD): National Institutes of Health (US); 2007. Understanding Emerging and Re-emerging Infectious Diseases. Available from: http://www.ncbi.nlm.nih.gov/books/NBK20370/
4. White R, Cutting KF. Modern exudate management: a review of wound treatments. World Wide Wounds. 2006; 1.
5. Kanani AG, Bahrami SH. Review on electrospun nanofibers scaffold and biomedical applications. Trends Biomater. Artif. Organs. 2010;24:93-115.
6. Huang ZM, Zhang YZ, Kotaki M, Ramakrishna S. A review on polymer nanofibers by electrospinning and their applications in nanocomposites. Compos. Sci. Technol. 2003;63:2223-2253.
7. Huang L, Nagapudi K, Apkarian RP, Chaikof EL. Engineered collagen-PEO nanofibers and fabrics. J. Biomater. Sci., Polym. Ed. 2001;12:979-993.
8. Li WJ, Laurencin CT, Caterson EJ, Tuan RS, Ko FK. Electrospun nanofibrous structure: a novel scaffold for tissue engineering. J. Biomed. Mater. Res. 2002;60:613-621.
9. Matthews JA, Wnek GE, Simpson DG, Bowlin GL. Electrospinning of collagen nanofibers. Biomacromolecules. 2002;3:232-238.
10. Park H-S, Park YO. Filtration properties of electrospun ultrafine fiber webs. Korean J. Chem. Eng. 2005;22:165-172.
11. Zheng F, Wang S, Wen S, Shen M, Zhu M, Shi X. Characterization and antibacterial activity of amoxicillin-loaded electrospun nano-hydroxyapatite/poly(lactic-co-glycolic acid) composite nanofibers. Biomaterials. 2013;34:1402-1412.
12. Wang S, Zheng F, Huang Y, Fang Y, Shen M, Zhu M, Shi X. Encapsulation of amoxicillin within laponite-doped poly(lactic-co-glycolic acid) nanofibers: preparation, characterization, and antibacterial activity. ACS Appl. Mater. Interfaces. 2012;4:6393-6401.
13. Qi R, Guo R, Zheng F, Liu H, Yu J, Shi X. Controlled release and antibacterial activity of antibiotic-loaded electrospun halloysite/poly(lactic-co-glycolic acid) composite nanofibers. Colloids Surf., B. 2013;110:148-155.
14. Kim B, Park H, Lee SH, Sigmund WM. Poly(acrylic acid) nanofibers by electrospinning. Mater. Lett. 2005;59:829-832.
15. Li L, Hsieh YL. Ultra-fine polyelectrolyte fibers from electrospinning of poly(acrylic acid). Polymer. 2005;46:5133-5139.
16. Atchison JS, Schauer CL. Fabrication and characterization of electrospun pristine and fluorescent composite poly (acrylic acid) ultra-fine fibers. J. Eng. Fiber Fabr. 2012;7:50-57.
17. Thompson CJ, Chase GG, Yarin AL, Reneker DH. Effects of parameters on nanofiber diameter determined from electrospinning model. Polymer. 2007;48:6913-6922.
18. Theron SA, Zussman E, Yarin AL. Experimental investigation of the governing parameters in the electrospinning of polymer solutions. Polymer. 2004;45:2017-2030.
19. Xiao SL, Shen MW, Ma H, Guo R, Zhu MF, Wang SY, Shi XY. Fabrication of water-stable electrospun polyacrylic acid-based nanofibrous mats for removal of copper (II) ions in aqueous solution. J. Appl. Polym. Sci. 2010;116:2409-2417.
20. Taepaiboon P, Rungsardthong U, Supaphol P. Drug-loaded electrospun mats of poly(vinyl alcohol) fibres and their release characteristics of four model drugs. Nanotechnology. 2006;17:2317-2329.
21. Suwantong O, Ruktanonchai U, Supaphol P. In vitro biological evaluation of electrospun cellulose acetate fiber mats containing asiaticoside or curcumin. J. Biomed. Mater. Res. A. 2010;94:1216-1225.
22. Zong XH, Kim K, Fang DF, Ran SF, Hsiao BS, Chu B. Structure and process relationship of electrospun bioabsorbable nanofiber membranes. Polymer. 2002;43:4403-4412.
23. Park CG, Kim E, Park M, Park JH, Choy YB. A nanofibrous sheet-based system for linear delivery of nifedipine. J. Control. Release. 2011;149:250-257.
24. Fang J, Wang X, Lin T. Functional applications of electrospun nanofibers. Nanofibersproduction, properties and functional applications. Rijeka: InTech-Open Access Publisher; 2011. p. 287-326.
25. Sill TJ, von Recum HA. Electrospinning: applications in drug delivery and tissue engineering. Biomaterials. 2008;29:1989-2006.
26. Pillay V, Dott C, Choonara YE, Tyagi C, Tomar L, Kumar P, Du Toit LC, Ndesendo VM. A review of the effect of processing variables on the fabrication of electrospun nanofibers for drug delivery applications. J. Nanomater. 2013;2013:1-22.