Vitamin K and cardiovascular calcification in CKD: Is patient supplementation on the horizon?

Kidney International

Volumn 86, Issue 2, 2014, Pages 232-234

  Gallieni, Maurizio ^a   Fusaro, Maria ^b  

^a SAN CARLO BORROMEO HOSPITAL   (Italy)

^b CNR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

4 CARBOXYGLUTAMIC ACID; GLUTAMIC ACID; GROWTH ARREST SPECIFIC PROTEIN 6; HYDROQUINONE; MENADIONE; MENADIONE EPOXIDE; MENAQUINONE; MENAQUINONE 7; MENATETRENONE; OSTEOCALCIN; PHYTOMENADIONE; PROTHROMBIN; QUINONE DERIVATIVE; UNCLASSIFIED DRUG; VITAMIN K DEPENDENT CARBOXYLASE; VITAMIN K GROUP; WARFARIN;

BLOOD CLOTTING; BLOOD VESSEL CALCIFICATION; BONE METABOLISM; CALCIFICATION; CARBOXYLATION; CARDIOVASCULAR CALCIFICATION; CARDIOVASCULAR DISEASE; CHRONIC KIDNEY DISEASE; CLINICAL TRIAL (TOPIC); CORONARY ARTERY CALCIFICATION; DIETARY INTAKE; DISEASE COURSE; DRUG EFFICACY; DRUG INHIBITION; DRUG USE; ENZYME ACTIVATION; ENZYME ACTIVITY; FRACTURE; HEMODIALYSIS PATIENT; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROCESSING; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; UREMIA; VITAMIN K DEFICIENCY; VITAMIN SUPPLEMENTATION; ANIMAL; MALE; METABOLISM;

ANIMALS; MALE; UREMIA; VITAMIN K;

EID: 84905383456     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2014.24     Document Type: Note

References (12)

1. Shearer MJ, Newman P. Metabolism and cell biology of vitamin K. Thromb Haemost 2008; 100: 530-547.
2. Fusaro M, Noale M, Viola V et al. Vertebral fractures, vascular calcifications, and mortality: Vitamin K Italian (VIKI) dialysis study. J Bone Miner Res 2012; 27: 2271-2278.
3. Confavreux CB, Szulc P, Casey R et al. Higher serum osteocalcin is associated with lower abdominal aortic calcification progression and longer 10-year survival in elderly men of the MINOS cohort. J Clin Endocrinol Metab 2013; 98: 1084-1092.
4. Gundberg CM, Lian JB, Booth SL. Vitamin K-dependent carboxylation of osteocalcin: friend or foe? Adv Nutr 2012; 3: 149-157.
5. Karsenty G, Oury F. Regulation of male fertility by the bone-derived hormone osteocalcin. Mol Cell Endocrinol 2014; 382: 521-526.
6. Al Rajabi A, Booth SL, Peterson JW et al. Deuterium-labeled phylloquinone has tissuespecific conversion to menaquinone-4 among Fischer 344 male rats. J Nutr 2012; 142: 841-845.
7. Kaesler N, Magdeleyns E, Herfs M et al. Impaired vitamin K recycling in uremia is rescued by vitamin K supplementation. Kidney Int 2014; 86: 286-293.
8. Westenfeld R, Krueger T, Schlieper G et al. Effect of vitamin K2 supplementation on functional vitamin K deficiency in hemodialysis patients: a randomized trial. Am J Kidney Dis 2012; 59: 186-195.
9. Caluwé R, Vandecasteele S, Van Vlem B et al. Vitamin K2 supplementation in haemodialysis patients: a randomized dose-finding study. Nephrol Dial Transplant advance online publication 2013; doi:10.1093/ndt/gft464 (e-pub ahead of print).
10. Shea MK, Holden RM. Vitamin K status and vascular calcification: evidence from observational and clinical studies. Adv Nutr 2012; 3: 158-165.
11. Shiraki M, Shiraki Y, Aoki C et al. Vitamin K2 (menatetrenone) effectively prevents fractures and sustains lumbar bone mineral density in osteoporosis. J Bone Miner Res 2000; 15: 515-521.
12. Cranenburg EC, Koos R, Schurgers LJ et al. Characterisation and potential diagnostic value of circulating matrix Gla protein (MGP) species. Thromb Haemost 2010; 104: 811-822.