Is ribavirin prophylaxis effective for nosocomial transmission of crimean-congo hemorrhagic fever?

Vector-Borne and Zoonotic Diseases

Volumn 14, Issue 8, 2014, Pages 601-605

  Guner, Rahmet ^a   Hasanoglu, Imran ^b   Tasyaran, Mehmet Akin ^a   Yapar, Derya ^c   Keske, Siran ^d   Guven, Tumer ^b   Yilmaz, Gul Ruhsar ^e  

^a YILDIRIM BEYAZIT UNIVERSITY   (Turkey)

^b ATATURK TRAINING AND RESEARCH HOSPITAL   (Turkey)

^c Inebolu State Hospital   (Turkey)

^d Polatli Duatepe State Hospital   (Turkey)

^e NONE

Author keywords

Crimean Congo hemorrhagic fever; Nosocomial transmission; Postexposure prophylaxis; Ribavirin

Indexed keywords

RIBAVIRIN; ANTIVIRUS AGENT;

ADULT; AEROSOL; ARTICLE; BODY FLUID; CLINICAL ARTICLE; CRIMEAN CONGO HEMORRHAGIC FEVER; DRUG EFFICACY; FOLLOW UP; HEALTH CARE PERSONNEL; HOSPITAL ADMISSION; HUMAN; LOADING DRUG DOSE; NEEDLESTICK INJURY; NURSE; PHYSICIAN; PRIORITY JOURNAL; PROPHYLAXIS; RETROSPECTIVE STUDY; VIRUS TRANSMISSION; DISEASE TRANSMISSION; FEMALE; HEMORRHAGIC FEVER, CRIMEAN; INFECTION CONTROL; NAIROVIRUS; OCCUPATIONAL EXPOSURE; POST EXPOSURE PROPHYLAXIS; PREVENTION AND CONTROL; PROCEDURES; TRANSMISSION; TURKEY;

ADULT; ANTIVIRAL AGENTS; FEMALE; HEALTH PERSONNEL; HEMORRHAGIC FEVER VIRUS, CRIMEAN-CONGO; HEMORRHAGIC FEVER, CRIMEAN; HUMANS; INFECTION CONTROL; INFECTIOUS DISEASE TRANSMISSION, PATIENT-TO-PROFESSIONAL; NEEDLESTICK INJURIES; OCCUPATIONAL EXPOSURE; POST-EXPOSURE PROPHYLAXIS; RIBAVIRIN; TURKEY;

EID: 84905276827     PISSN: 15303667     EISSN: 15577759     Source Type: Journal    
DOI: 10.1089/vbz.2013.1546     Document Type: Article

References (30)

1. Bente DA, Alimonti JB, Shieh WJ, Camus G, et al. Pathogen-esis and immune response of Crimean-Congo hemorrhagic fever virus in a STAT-1 knockout mouse model. J Virol 2010; 84:11089-11100.
2. Bodur H, Akinci E, Ongürü P, Carhan A, et al. Detection of Crimean-Congo hemorrhagic fever virus genome in saliva and urine. Int J Infect Dis 2010; 14:247-249.
3. Burney MI, Ghafoor A, Saleen M, Webb PA, et al. Nosocomial outbreak of viral hemorrhagic fever caused by Crimean He-morrhagic fever-Congo virus in Pakistan, January 1976. Am J Trop Med Hyg 1980; 29:941-947.
4. Celikbas AK, Dokuzoguz B, Baykam N, Gok SE, et al. Crimean-Congo hemorrhagic fever among health care workers, Turkey. Emerg Infect Dis 2014; http://dx.doi.org/10.3201/eid2003.131353
5. Dokuzoguz B, Celikbas AK, Gök SxE, Baykam N, et al. Severity scoring index for Crimean-Congo hemorrhagic fever and the impact of ribavirin and corticosteroids on fatality. Clin Infect Dis 2013; 57:1270-1274.
6. Elaldi N, Bodur H, Ascioglu S, Celikbas A, et al. Efficacy of oral ribavirin treatment in Crimean-Congo haemorrhagic fever: A quasi-experimental study from Turkey. J Infect 2009; 58:238-244.
7. Ergonul O. Crimean-Congo haemorrhagic fever. Lancet Infect Dis 2006; 6:203-214.
8. Ergonul O. DEBATE (see Elaldi N et al, Efficacy of oral ri-bavirin treatment in Crimean-Congo haemorrhagic fever: A quasi-experimental study from Turkey. J Infect 2009; 58: 238-244.) Biases and misinterpretation in the assessment of the efficacy of oral ribavirin in the treatment of Crimean-Congo hemorrhagic fever. J Infect 2009; 59: 284-286; author reply 286-289.
9. Ergonul O, Celikbas A, Dokuzoguz B, Eren M, et al. Characteristics of patients with Crimean-Congo hemorrhagic fever in a recent outbreak in Turkey and impact of oral ribavirin therapy. Clin Infect Dis 2004; 39:284-287.
10. Fisher-Hoch SP, Khan JA, Rehman S, Mirza S, et al. Crimean Congo-haemorrhagic fever treated with oral ribavirin. Lancet 1995; 346:472-475.
11. Fisher-Hoch SP. Lessons from nosocomial viral haemorrhagic fever outbreaks. Br Med Bull 2005; 73-74:123-137.
12. Gurbuz Y, Sencan I, Ozturk B, Tutuncu E. A case of nosoco-mial transmission of Crimean-Congo hemorrhagic fever from patient to patient. Int J Infect Dis 2009; 13:105-107.
13. Izadi S, Salehi M. Evaluation of the efficacy of ribavirin therapy on survival of Crimean-Congo hemorrhagic fever patients: A case-control study. Jpn J Infect Dis 2009; 62:11-15.
14. Karti SS, Odabasi Z, Korten V, Yilmaz M, et al. Crimean-Congo hemorrhagic fever in Turkey. Emerg Infect Dis 2004; 10:1379-1384.
15. Koksal I, Yilmaz G, Aksoy F, Aydin H, et al. The efficacy of ribavirin in the treatment of Crimean-Congo hemorrhagic fever in Eastern Black Sea region in Turkey. J Clin Virol 2010; 47:65-68.
16. Leblebicioglu H. Ribavirin treatment for Crimean-Congo hemorrhagic fever. Jpn J Infect Dis 2009; 62:485-486.
17. Mardani M, Jahromi MK, Naieni KH, Zeinali M. The efficacy of oral ribavirin in the treatment of crimean-congo hemor-rhagic fever in Iran. Clin Infect Dis 2003; 36:1613-1618.
18. Mardani M, Keshtkar-Jahromi M. Crimean-Congo hemorrhagic fever. Arch Iran Med 2007a; 10:204-214.
19. Mardani M, Rahnavardi M, Rajaienejad M, Holakoui Naini K, et al. Crimean-Congo hemorrhagic fever among health care workers in Iran: A seroprevalence study in two endemic regions. Am J Trop Med Hyg 2007b; 76:443-445.
20. Mardani M, Keshtkar-Jahromi M, Ataie B, Adibi P. Crimean-Congo hemorrhagic fever virus as a nosocomial pathogen in Iran. Am J Trop Med Hyg 2009; 81:675-678.
21. Nabeth P, Cheikh DO, Lo B, Faye O, et al. Crimean-Congo hemorrhagic fever, Mauritania. Emerg Infect Dis 2004; 10: 2143-2149.
22. Suleiman MN, Muscat-Baron JM, Harries JR, Satti AG, et al. Congo/Crimean haemorrhagic fever in Dubai. An outbreak at the Rashid Hospital. Lancet. 1980; 2:939-941.
23. Tarantola A, Ergonul O, Tattevin P. Estimates and prevention of Crimean-Congo hemorrhagic fever risks for health-care workers. In: Ergonul O, Whitehouse CM, eds. Crimean-Congo Hemorrhagic Fever. A Global Perspective. The Netherlands: Springer; 2007:99-114.
24. Tasdelen Fisgin N, Ergonul O, Doganci L, Tulek N. The role of ribavirin in the therapy of Crimean-Congo hemorrhagic fever: early use is promising. Eur J Clin Microbiol Infect Dis 2009; 28:929-933.
25. Tignor GH, Hanham CA. Ribavirin efficacy in an in vivo model of Crimean-Congo hemorrhagic fever virus (CCHF) infection. Antiviral Res 1993; 22:309-325.
26. Tutuncu EE, Gurbuz Y, Ozturk B, Kuscu F, et al. Crimean Congo haemorrhagic fever, precautions and ribavirin prophylaxis: A case report. Scand J Infect Dis 2009; 41:378-380.
27. van Eeden PJ, Joubert JR, van de Wal BW, King JB, et al. A nosocomial outbreak of Crimean-Congo haemorrhagic fever at Tygerberg Hospital. Part I. Clinical features. S Afr Med J 1985a; 68:711-717.
28. van Eeden PJ, van Eeden SF, Joubert JR, King JB, et al. A nosocomial outbreak of Crimean-Congo haemorrhagic fever at Tygerberg Hospital. Part II. Management of patients. S Afr Med J 1985b; 68:718-721.
29. Whitehouse CA. Crimean-Congo haemorrhagic fever. Antiviral Res 2004; 64:145-160.
30. Yilmaz GR, Buzgan T, Irmak H, Safran A, et al. The epidemiology of Crimean-Congo hemorrhagic fever in Turkey, 2002-2007. Int J Infect Dis 2009; 13:380-386.