Attenuation of Phosphorylated connexin-43 protein levels in Diabetic rat heart by regular moderate exercise

Archives of Iranian Medicine

Volumn 17, Issue 8, 2014, Pages 569-573

  Hesari, Farzam Sheikhzadeh ^a   Khajehnasiri, Nazli ^a,b   Khojasteh, Seyed Mahdi Banan ^e   Soufi, Farhad Ghadiri ^c   Dastranj, Ali ^d  

^a UNIVERSITY OF TABRIZ   (Iran)

^b HIGHER EDUCATION INSTITUTE OF RAB RASHID   (Iran)

^c HORMOZGAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^e NONE

Author keywords

Arrhythmia; Blood glucose; Exercise; Phosphorylated connexin 43

Indexed keywords

CONNEXIN 43; PHOSPHOPROTEIN; BLOOD GLUCOSE; CONNEXIN 43 PROTEIN, RAT;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DIABETIC CARDIOMYOPATHY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXERCISE; GLUCOSE BLOOD LEVEL; HEART ARRHYTHMIA; HEART MUSCLE; HEART VENTRICLE; HISTOPATHOLOGY; NONHUMAN; PANCREAS; RAT; ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; HEART VENTRICLES; METABOLISM; MYOCARDIUM; PATHOLOGY; PHOSPHORYLATION; PHYSICAL CONDITIONING, ANIMAL; RATS; RATS, WISTAR;

ANIMALS; BLOOD GLUCOSE; CONNEXIN 43; DIABETES MELLITUS, EXPERIMENTAL; HEART VENTRICLES; MYOCARDIUM; PHOSPHORYLATION; PHYSICAL CONDITIONING, ANIMAL; RATS; RATS, WISTAR;

EID: 84905260248     PISSN: 10292977     EISSN: 17353947     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Silva M, Peluzio M C, Amorim P, Lavorato V, Santos N, Bozi L, et al. Swimming training attenuates contractile dysfunction in diabetic rat cardiomyocyets. ArgBras Cardiol. 2011; 97: 33-39
2. Howarth F, Chandler N, Kharche S, Tellez J, Greener I, Yamanushi T, et al. Effects of streptozotocin-induced diabetes on connexin43 mRNA and protein in ventricle muscle. Mol Cell Biochem. 2008; 319: 105 -114.
3. Fromaget C, El Aoumari A, Gros D. Distribution pattern of connex-in43, a gap junctional protein, during the differentiation of mouse heart myocytes. Differentiation. 1992; 51: 9-20.
4. Inoguchi T, Yu H, Imamura M. Altered gap junction activity in cardiovascular tissues of diabetes. Med Electron Microsc. 2001; 34: 86-91.
5. Yeager M. Structure of cardiac gap junction intracellular channels. J Struct Biol. 1998; 121: 231-245.
6. Dhein S. Gap junction channels in the cardiovascular system: pharmacological and physiological modulation. TiPS. 1998; 19: 229-241.
7. Mitasikova M, Lin H, Soukup T, Imanaga I, Tribulova N. Diabetes and thyroid hormones effect connexin43 and pkc epsilon expression on heart atria. Physiol Res. 2009; 58: 211-217.
8. Kuroki T, Inoguchi T, Umeda F, Ueda F, Naeata H. High glucose induces alteration of gap junction permeability and phosphorylation of connexin-43 in cultured aortic smooth muscle cells. Diabetes. 1998; 48: 931-936.
9. Loganathan L, Novikova L, Boulatnikov IG, Smirnova AV. Exercise induced cardiac performance in autoimmune (Type 1) diabetes is associated with a decrease in myocardial diacylglycerol. J Appl Physiol. 2012; 113: 817-826.
10. Chipkin SR, Klugh SA, Chasan-Taber L. Exercise and diabetes. Car-diol Clin. 2001; 19: 489-505.
11. De Angelis k, Oliveira A, Dall Ago P, A Peixoto P, Gadonski G, Lacchini S, et al Effects of exercise training on autonomic and myocardial dysfunction in streptozotosin-diabetic rats. Braz J Med Biol Res. 2000; 33: 635-641.
12. Gulve, E.Exercise and glycemic control in diabetes: benefits, challenges, and adjustments to pharmacotherapy. Phys Ther. 2008; 88: 1297-1321.
13. Shao C, Wehrens X, Wyatt T, Parbhu S, Rozanski G, Patel K, et al.Exercise training during diabetes attenuates cardiac ryanodine receptor dysregulation. JAppl Physiol. 2009; 106: 1280-1292.
14. Bidasee K, Zheng H, Shao C, Parbhu S, Rozanski G Patel K. Exercise training initiated after the onset of diabetes preserves myocardial function: effects on expression of beta-adrenoceptors. J Appl Physio. 2008; 105: 907-914.
15. Ha H, Kim C, Son YS, Chung MH, Kim KH. DNA damage in the kidneys of diabetic rats exhibiting microalbuminuria. Free Radic Biol Med. 1994; 16: 271-274.
16. Ozkan, Y, Yilmaz, O. Ozturk A, Erşan A. Effects of triple antioxidant combination (vitamin E, vitamin C and alpha-lipoic acid) with insulin on lipid and cholesterol levels and fatty acid composition of brain tissue in experimental diabetic and non-diabetic rats. Cell Biol Int. 2005; 29: 754-760.
17. Taylor R, Ciccolo J. & Starne J Effect of exercise training on the ability of the rat heart to tolerate hydrogen peroxide. Cardiovasc Res. 2003; 59: 575-581.
18. Lee M Treadmill exercise enhances nitric oxide synthase expression in the hippocampus of food-deprived rats. Nutr Res. 2005; 12: 771-779.
19. Ayoub R. Effect of exercise on spatial learning and memory in male diabetic rats. Int J Diabetes Metab. 2009; 17: 93-98.
20. Howarth F, Nowotny N, Zilahi E, El Haj M, Lei M. Altered expression of gap junction connexin proteins may partly underlie heart rhythm disturbances in the streptozotocin-induced diabetic rat heart. Molecular and Cellular Biochemistry. 2007a; 305: 145-151.
21. Lin H, Ogawa K, Imanaga L, Tribulova N Remodeling of connex-in-43 in the diabetic rat heart. Mol Cell Biochem. 2006; 290: 69-78.
22. Schnedl W, Ferber S, Johnson, J. Newgard C. STZ transport and cyto-toxicity: specific enhancement in GLUT2-expressing cells. Diabetes. 1994; 43: 1326-1333.
23. Howarth F, Al-Ali S, Al-Sheryani S, Al-Dhaheri H, Al-Junaibi S, Al- mugaddum F, Qureshi M Effects of voluntary exercise on heart function in streptozotocin- induced diabetic rat. Int J Diabetes Metabo. 2007b; 15: 32-37.
24. Howarth F, Almugaddum F, Qureshi M, Ljubisavljevic M. The effects of heavy long-term exercise on ventricular myocyte shortening and intracellular Ca2+ in streptozotocin-induced diabetic rat. J Diabetes Complications. 2010; 24: 278-285.
25. 2+ cycling proteins expression in type 1 diabetic rats. Appl Physiol Nutr Metab. 2012; 37: 53-62.
26. Praet SF, Manders RJ, Lieverse AG, Kuipers H, Stehouwer CD, Keizer HA, et al Influence of acute exercise on hyperglycemia in insulin- treated type 2diabetes. Med Science Sports Exerc. 2006; 38: 2037-2044.
27. Loganathan R, Bilgen M, Al-Hafez M. V. Zhero S, Alenezy M, Smirnova L. Exercise training improves cardiac performance in diabetes: in vivo demonstration with quantitative cine-MRI analyses. J ApplPhysiol. 2007; 102: 665-672.